原核生物免疫系统，冷冻电镜

2017/09-2021/12    中国科学技术大学   生物化学与分子生物学        博士

2015/09-2017/06    中国科学技术大学   生物化学与分子生物学        硕士

2011/09-2015/06    中国科学技术大学   生命科学                            学士

2024/05-至今                 南方科技大学，医学院             研究助理教授

2022/01-2024/04              南方科技大学，医学院               博士后

[1] DUAN Z#, ZHANG X#, ZHANG J-T#, JI X#, LIU R, CHEN Y, LI S, JIA N, GAO H, XIN Y, JIA N*, ZHU J-K*. Structure and genome editing activity of the novel CRISPR-Cas12o1 effector [J]. Cell Research, 2024, DOI:10.1038/s41422-024-01050-y.

[2] CUI N#, ZHANG J-T#, LI Z, WEI X-Y, WANG J, JIA N*. Tetramerization-dependent activation of the Sir2-associated short prokaryotic Argonaute immune system [J]. Nature communications, 2024, 15(1): 8610. DOI:10.1038/s41467-024-52910-5.

[3] ZHANG J-T#, LIU X-Y#, LI Z#, WEI X-Y, SONG X-Y, CUI N, ZHONG J, LI H, JIA N*. Structural basis for phage-mediated activation and repression of bacterial DSR2 anti-phage defense system [J]. Nature Communications, 2024, 15(1). DOI:10.1038/s41467-024-47177-9

[4] ZHANG J-T#, WEI X-Y#, CUI N, TIAN R, JIA N*. Target ssDNA activates the NADase activity of prokaryotic SPARTA immune system [J]. Nature Chemical Biology, 2024, 20(4). DOI:10.1038/s41589-023-01479-z.

[5] CUI N#, ZHANG J-T#, LIU Y, LIU Y, LIU X-Y, WANG C, HUANG H*, JIA N*. Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment [J]. Molecular Cell, 2023, 83(14): 2493-2508. DOI:10.1016/j.molcel.2023.05.036

[6] CUI N#, ZHANG J-T#, LI Z, LIU X-Y, WANG C, HUANG H*, JIA N*. Structural basis for the non-self RNA-activated protease activity of the type III-E CRISPR nuclease-protease Craspase [J]. Nature Communications, 2022, 13(1):

[7] ZHANG J T, YANG F, DU K, LI W F, CHEN Y X, JIANG Y L, LI Q, ZHOU C Z*. Structure and assembly pattern of a freshwater short-tailed cyanophage Pam1 [J]. Structure, 2022, 30(2): 240-251.