Zongqiang Li is an assistant professor and doctoral supervisor in the Department of Pharmacology at the Medical School of Southern University of Science and Technology. He obtained his PhD from Tsinghua University in 2022, during which he also served as a postdoctoral researcher at the School of Life Sciences from 2022 to 2024. He has received prestigious honors and awards including the "Outstanding Doctoral Dissertation Award" from Tsinghua University, the "Special Postdoctoral Fund" from Tsinghua-Peking Joint Center for Life Sciences, and recognition as an "Excellent Scholar" at Beijing Frontier Research Center for Biological Structure. He has successfully led multiple research projects funded by organizations such as National Natural Science Foundation, China Postdoctoral Science Foundation. As a first or co-author, he has published numerous significant research findings in internationally renowned journals including Nature, Cell, Cell Research, and Nature Communications. His research group primarily employs techniques encompassing cell biology, molecular biology, biochemistry, and structural biology to investigate the structure and function of key disease-related biomolecules.
The investigations of biological macromolecules and their complexes associated with severe diseases primarily focus on elucidating the molecular mechanisms underlying neurodegenerative disorders triggered by nuclear pore complex dysfunction, as well as exploring the interplay between pathogens and host cells from a structural and functional perspective.
2017.9-2022.7 Ph.D School of Life Sciences，Tsinghua University
2013.9-2016.7 M.D. School of Life Sciences，Huazhong Agricultural University
2009.9-2013.7 B.S. College of Animal Science and Technology，Henan University of Science and Technology
2024.7-Now Assistant professor, Department of Pharmacology, School of Medicine, Southern University of Science and Technology
2022.8-2024.7 Postdoctor, School of Life Sciences, Tsinghua University
2016.7-2017.8 Research assistant, Key Laboratory of Nucleic Acid Biology, CAS, Institute of Biophysics, Chinese Academy of Sciences
2023 Distinguished scholar of Beijing Frontier Research Center of Biological Structure
2023 Best Poster Award of the 8th National symposium of cryo-EM and structural biology
2022 Excellent doctoral thesis of Tsinghua University
2022 Postdoctoral foundation at center for life sciences of Tsinghua-Peking University
2022 Best Poster Award of 2022 Chinese Biophysics Congress
1. Zongqiang Li, Shuaijiabin Chen, Liang Zhao, Guoqiang Huang, Huiqin Xu, Xiaoyun Yang, Peiyi Wang, Ning Gao, Sen-Fang Sui. (2023) Nuclear export of the pre-60S particles through nuclear pore complex. Nature,618(7964):411-418
2. Zongqiang Li, Shuaijiabin Chen, Liang Zhao, Guoqiang Huang, Xiong Pi, Shan Sun, Peiyi Wang, Sen-Fang Sui. (2022) Near atomic structure of the inner ring of the Saccharomyces cerevisiae nuclear pore complex. Cell Research,0,1-14.
3. Xiaoyun Yang, Zongqiang Li, Liang Zhao, Zengqiang Gao, Sen-Fang Sui, Yuhui Dong, Yanhua Li. (2022) Structural insights into PA3488-mediated inactivation of Pseudomonas aeruginosa PldA. Nat Commun,13(1):5979. (co-first author)
4. Liang Liu, Xueyan Li, Jun Ma, Zongqiang Li, Lilan You, Jiuyu Wang, Min Wang, Xinzheng Zhang , Yanli Wang. (2017) The Molecular Architecture for RNA-Guided RNA Cleavage by Cas13a. Cell, 170(4):714‐726.e10. (co-first author)
5. Xiaoyun Yang, Zongqiang Li, Zhun She, Zhi Geng, Jianhua Xu, Zengqiang Gao, Yuhui Dong. (2016) Structural analysis of Pseudomonas aeruginosa H3-T6SS immunity proteins. FEBS Lett, 590, 2787-2796. (co-first author)
6. Xiaoyun Yang, Zongqiang Li, Zengqiang Gao, Wenjia Wang, Zhi Geng, Jianhua Xu, Zhun She, and Yuhui Dong. (2017) Structural and SAXS analysis of Tle5-Tli5 complex reveals a novel inhibition mechanism of H2-T6SS in Pseudomonas aeruginosa. Protein Science, 26(10):2083-2091.
7. Weihui Li, Tao Cui, Lihua Hu, Ziqing Wang, Zongqiang Li, Zheng-Guo He. (2015) Cyclic diguanylate monophosphate directly binds to human siderocalin and inhibits its antibacterial activity. Nature communications, 6:8330.
8. Xiaoyun Yang, Yanhua Li, Zengqiang Gao, Zongqiang Li, Jianhua Xu, Wenjia Wang, Yuhui Dong. (2017) Structural analysis of Wss1 protein from saccharomyces cerevisiae. Scientific Reports, 7(1):8270.
9. Qiao Xue, Huisheng Liu, Zixiang Zhu, Fan Yang, Yingying Song, Zongqiang Li, Zhaoning Xue, Weijun Cao, Xiangtao Liu, Haixue Zheng. (2022) African Swine Fever Virus Regulates Host Energy and Amino Acid Metabolism To Promote Viral Replication. Journal of Virology, 96(4):e0191921.
10. Huisheng Liu, Zixiang Zhu, Qiao Xue, Fan Yang, Zongqiang Li, Zhaoning Xue,Weijun Cao, Jijun He, Jianhong Guo, Xiangtao Liu, Andrew E. Shaw, Donald P. King, Haixue Zheng. (2023) Innate sensing of picornavirus infection involves cGAS-STING-mediated antiviral responses triggered by mitochondrial DNA release. PLOS Pathogens, 19(2):e1011132.
