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Xiao Guozhi

Associate Dean of the School of Medicine，Professor

xiaogz@sustech.edu.cn

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个人简介

Professor Guozhi Xiao is an internationally renowned bone biologist. Dr. Xiao obtained his PhD degree in biochemistry and molecular biology from Peking University in 1994. He finished his post-doc training (1994-1998) and worked as a research scientist (1998-2005) at the University of Michigan Ann Arbor. In 2005, he assumed an independent faculty position as a tenure-track assistant professor at the University of Pittsburgh School of Medicine in 2005 and was promoted to the level of associate professor with tenure in 2011. In 2012, he joined Rush University Medical Center in Chicago and assumed a prominent academic position as the Dr. Ralph and Marian C. Falk Endowed Chair Professor of Biochemistry and served as the director of research of the department of biochemistry. In 2013, he joined the SUSTech as a tenured full professor and later became the chair of the biological department. Dr. Xiao is the director of the Center for Experimental Animals at SUSTech. Dr. Xiao has made several contributions to our understanding the molecular control of skeletal development and homeostasis. His work is reported in 107 peer-reviewed SCI-indexed full-length research articles, many in high profile journals, such as the Journal of Clinical Investigation and Nature Communications etc., and 30 review articles and book chapters etc. He serves as a reviewer for the US National Science Foundation, the Italian Ministry of Health and the National Natural Science Foundation of China and sits on the editorial boards of the Journal of Bone and Mineral Research (JBMR) and the Journal of Biological Chemistry (JBC). Dr. Xiao’s research interests focus in the following areas: (1) to determine how osteoblast, osteoclast, and chondrocyte formation is controlled during skeletal development and homeostasis under physiological and pathological conditions; (2) to define the mechanisms that modulate bone angiogenesis; and more recently, (3) to study the roles of focal adhesion (FA) proteins in skeletal development and homeostasis. By working on these projects, Xiao laboratory has also maintained a focus on important medical issues involving bone –osteoarthritis, osteoporosis, metastatic osteolytic lesions, and fracture healing. Information obtained from these studies will enhance our understanding of these pathological processes.


研究领域

My research focuses include: 1) mechanisms that control bone and cartilage development and homeostasis; 2) mechanisms of cancer bone metastases; 3) mechanisms that modulate bone angiogenesis during skeletal development and homeostasis; and 4) the role of cell adhesion molecules such as Kindlin-2 and migfilin in bone and cartilage. By working on these projects, I also maintain a focus on medical issues involving bone – osteoporosis, osteoarthritis and metastatic osteolytic lesions and fracture healing. Information obtained from these studies will enhance our understanding of these pathological processes.

教育背景

1979-1984：Nanchang University School of Medicine, Bachelor Degree of Medicine.
1985-1988：Peking University Health Sciences Center, Department of Biochemistry and Molecular Biology, Master Degree.
1991-1994： Peking University Health Sciences Center, Department of Biochemistry and Molecular Biology, Ph.D.

工作经历

2015-present: Chair, Department of Biology, Southern University of Science and Technology, Shenzhen
2013-present: Professor and Chair, Department of Biology, Southern University of Science and Technology, Shenzhen.
2011-2013: Associate professor, Director of Research, Ralph and Marian C. Falk Endowed Professor of Biochemistry of Rush University.
2005-2011: Assistant professor/Associate professor (with tenure), University of Pittsburgh School of Medicine.
1998-2005: Instructor/Research assistant professor, University of Michigan School of Dentistry (Ann Arbor).
1994-1998：Post doctor, University of Michigan School of Dentistry (Ann Arbor).

获奖情况及荣誉

1998 ASBMR Young Investigator Award
2012 Outstanding Alumni, Beijing Medical University (Currently Peking University Health Sciences Center)
2013-present: Shenzhen Pengcheng Scholar
2017-present: Shenzhen Peacock Scholar

近年代表文章

From total 200 publications

  1. Walke W, Xiao G, and Goldman D. A dual function activity-dependent, muscle-specific enhancer from rat nicotinic acetylcholine receptor d-subunit gene. J Neurobiol. 1996; 31(3): 359-369.

  2. Walke W, Xiao G, and Goldman D. Identification and characterization of a 47 base pair activity-dependent enhancer of the rat nicotinic acetylcholine receptor d-subunit promoter. J Neurosci. 1996; 16(11): 3641-3651.

  3. Xiao G, Cui Y, Ducy P, Karsenty G, and Franceschi RT. Ascorbic acid-dependent activation of the osteocalcin promoter in MC3T3-E1 preosteoblasts: requirement for collagen matrix synthesis and the presence of an intact OSE2 sequence. Mol Endocrinol. 1997; 11:1103-1113.

  4. Xiao G, Wang D, Benson MD, Karsenty G, and Franceschi RT. Role of the a2 integrin in osteoblast-specific gene expression and activation of the Osf2 transcription factor. J Biol Chem. 1998; 273, 32988-32994.

  5. Frendo JL, Xiao G, Fuches S, Franceschi RT, Karsentry G, and Ducy P. Functional hierarchy between two OSE2 elements in the control of osteocalcin expression in vivo. J Biol Chem. 1998; 273, 30509-30516.

  6. Wang D, Christensen, K, Chawla, K, Xiao G, Krebsbach P. and Franceschi, RT. Isolation and characterization of MC3T3-E1 murine preosteoblast subclones with distinct in vitro and in vivo differentiation/mineralization potential. J Bone Miner Res. 1999; 14:893-903.

  7. Benson MD, Aubin JE, Xiao G, Thomas PE, and Franceschi RT. Cloning of a 2.5 kb murine bone sialoprotein promoter fragment and functional analysis of putative Cbf/runt binding sites. J Bone Miner Res. 1999; 14:396-405.

  8. Xiao G, Jiang D, Thomas PE, Benson MD, Guan KL, Karsenty G, and Franceschi RT. MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Osf2/Cbfa1. J Biol Chem. 2000; 275, 4453-4459. 

  9. Benson MD, Bargeon JL, Xiao G, Thomas PE, Ahn Kim, Yingqi Cui, and Franceschi RT. Identification of a homeodomain binding element in the bone sialoprotein gene promoter which is required for its osteoblast-selective expression. J Biol Chem. 2000; 275: 13907-13917.

  10. Franceschi RT. Xiao G, Thomas PE, Jiang D, and Benson MD. Extracellular matrix regulation of osteoblast-specific gene expression: role of the a2b1 integrin and Osf2/Cbfa1. Chemistry and Biology of Mineralized Tissues: Connect Tissue Res. 2000;41 Suppl 1:249-254.

  11. Ma PX, Zhang R, Xiao G, and Franceschi RT. Engineering new bone tissue in vitro on highly pore poly(-hydroxyl acids)/hydroxyapatite composite scaffolds. J Biomed Mater Res. 2001; 54:284-293.

  12. Xiao G, Jiang D, Gopalakrishnan R, and Franceschi RT. FGF-2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2. J Biol Chem. 2002; 277:36181-36187.

  13. Zhao M, Xiao G, Berry J, Franceschi RT, Reddi A, and Somerman MJ. Bone Morphogenetic Protein 2 induces dental follicle cells to differentiate toward a cementoblast/osteoblast phenotype. J Bone Miner Res. 2002; 17:1441-1451. 

  14. Xiao G, Gopalakrishnan R, Jiang D, Reith E, Benson MD, and Franceschi RT. BMP, extracellular matrix, and MAP kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells. J Bone Miner Res. 2002; 17:101-110.

  15. Franceschi RT and Xiao G. Regulation of osteoblast-specific transcription factor, Runx2: Responsiveness to multiple signal transduction pathways. J Cell Biochem. 2003; 88:446-454.

  16. Franceschi RT. Xiao G, Jiang D, Gopalakrishnan R, Yang S and Reith E. Multiple signaling pathways converge on the Cbfa1/Runx2 transcription factor to regulate osteoblast differentiation: Connect Tissue Res. 2003;44 Suppl 1:109-16.

  17. Chen C, Koh AJ, Datta NS, Zhang J, Even ET, Xiao G, Franceschi RT, D'Silva NJ, and McCauley LK. Impact of mitogen-activated protein kinase (MAPK) pathway on parathyroid hormone related protein actions in osteoblasts. J Biol Chem. 2004; 279, 29121-29129.

  18. Jiang D, Franceschi RT, Boules H, and Xiao G*. Parathyroid Hormone Induction of the Osteocalcin Gene:requirement for an osteoblast-specific element 1 sequence in the promoter and involvement of multiple signaling pathways. J Biol Chem. 2004; 279:5329-5337.

  19. Xiao G*, Jiang D, Ge C, Zhao Z, Yumei Lai, Boules H, Phimphilai M, Yang X, Karsenty G, and Boules H, and Franceschi RT. Cooperative interactions between activating transcription factor 4 and Runx2/Cbfa1 stimulate osteoblast-specific osteocalcin gene expression. J Biol Chem. 2005; 280:30689-30696.

  20. Roca H, Phimphilai M, Gopalakrishnan R, Xiao G, and Franceschi RT. Cooprative interactions between RUNX2 and homeodomain protein binding sites are critical for the osteoblast-specific expression of the bone sialoprotein gene. J Biol Chem. 2005; 280:30845-30855.

  21. Zhao Z, Zhao M, Xiao G, and Franceschi RT. Gene transfer of the Runx2 transcription factor enhances osteogenic activity of bone marrow stromal cells in vitro and in vivo. Mol Ther. 2005; 12(2):247-53.

  22. Lu, Y, Cai Z, Galson DL, Xiao G, Liu, Y, George DE, Melhem MF, Yao Z, Zhang J. Monocyte chemotactic protein-1 (MCP-1) acts as a paracrine and autocrine factor for prostate cancer growth and invasion. Prostate. 2006; 66(12): 1311-8.

  23. Franceschi RT, Xiao G. Osteoblasts: Staying the course. Meeting report from the 29th Annual Meeting of the American Society for Bone and Mineral Research. BoneKEy-Osteovision 2006; 4 (12), 327-332.

  24. Zhu J, Jia X, Xiao G, Kang Y, Partridge, NC, Qin L. EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors in osteoblasts: implications in osteolytic bone metastases. J Biol Chem.2007; 282(37): 26656-64.

  25. Franceschi RT, Ge C, Xiao G, Roca H, Jiang D. Transcriptional regulation of osteoblasts. Ann N Y Acad Sci. 2007; 1116:196-207.

  26. Lu Y, Xiao G, Galson DL, Nishio Y, Mizokami A, Keller E, Yao Z, and Zhang J. PTHrP-induced production of monocyte chemoattractant protein-1 (MCP-1) by human bone marrow endothelial cells and osteoblasts promotes osteoclast differentiation in vitro: a novel role in prostate cancer bone metastasis. Int J Cancer. 2007; 121(4): 724-733.

  27. Lu Y, Cai Z, Xiao G, Liu Y, Keller E, Yao Z, and Zhang J. CCR2 expression correlates with prostate cancer progression. J Cell Biochem. 2007; 101(3): 676-85.

  28. Lu Y, Cai Z, Xiao G, Yao Z, Anderson JL, Roodman DG, and Zhang J. Prostate cancer cells induce osteoclastogenesis and bone resorption through RANKL-independent interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) production. Cancer Res. 2007; 67(8): 3646-53.

  29. Ge C, Xiao G, Jiang D, and Franceschi RT. Critical role of extracellular signal-regulated kinase/MAPK pathway in osteoblast differentiation and skeletal development. J Cell Biol. 2007; 176(5): 709-818. PMCID: PMC2064027.

  30. Feng, R, Anderson G, Xiao G, Elliot G, Leoni L, Lapara MY, Roodman GD, and Lentzsch S. SDX-308, a non-steroidal anti-inflammatory agent, inhibits NF-kB activity resulting in strong inhibition of osteoclast formation/activity and multiple myeloma cell growth. Blood. 2007; 109(3): 2130-2138.

  31. Yu S, Franceschi RT, Luo M, Zhang X, Jiang D, Lai Y, Jiang Y, Zhang J, Xiao G. Parathyroid hormone increases activating transcription factor 4 expression and activity in osteoblasts: requirement for osteocalcin gene expression. Endocrinology. 2008; 149(4): 1960-8. PMCID: PMC2276723.

  32. Singha UK, Jiang Y. Yu S, Luo M, Lu Y, Zhang J, Xiao G. Rapamycin inhibits osteoblast proliferation and differentiation in MC3T3-E1 cells and primary mouse bone marrow stromal cells. J Cell Biochem. 2008 Feb 1;103(2):434-46. doi: 10.1002/jcb.21411.PMID: 17516572。

  33. Chen D, Xiao G, Zhang M, Xing L, and Jonason JH. Post-translational regulation of Runx2 in bone cells. J Dent Res. 2008; 88(8): 693-703.

  34. Franceschi RT, Ge C, Xiao G, Roca H, Jiang D. Transcriptional regulation of osteoblasts. Cells Tissues Organs. 2009;189(1-4):144-152.

  35. Yu S, Jiang Y, Galson DL, Luo M, Lai Y, Lu Y, Ouyang HJ, Zhang J, Xiao G. General transcription factor IIA-gamma increases
osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2. J Biol Chem.  2008; 283(9): 5542-53. PMCID: PMC2736298.

  36. Zhang X, Yu S, Galson, DL, Luo M, Fan J, Zhang J, Guan Y, Xiao G. Activating
transcription factor 4 is critical for proliferation and survival in primary bone marrow stromal cells and calvarial osteoblasts. J Cell Biochem. 2008; 105(3): 885-95. PMCID: PMC2704124.

  37. Liu Y, Yuan Y, Li Y, Zhang J, Xiao G, Vodovotz Y, Billiar TR, Wilson M, Fan J. Interacting neuro-endocrine, innate, and acquired immune pathways regulate neutrophil from bone marrow following hemorrhage shock. J Immnol. 2009;182(1):572-580. PMCID: PMC2610356.

  38. Cai, Z, Chen Q, Chen J, Lu Y, Xiao G, Wu Z, Zhou Q, Zhang J. Monocyte chemotactic protein-1 promotes lung cancer-induced bone resorptive lesion in vivo. Neoplasia. 2009;11(3):228-36. PMCID: PMC2647725.

  39. Yu S, Franceschi RT, Luo M, Fan J, Jiang D, Cao H, Lai Y, Zhang J, Patrene K, Hankenson KD, Roodman GD, Xiao G. Critical role of activating transcription factor 4 in the anabolic actions of PTH in bone. PLoS One. 2009, Oct 23;4(10):e7583. PMCID: PMC2762317. (This paper was listed as the "Not to be Missed" paper in the November (2009) issue of the IBMS BoneKEy. BoneKEy is published by the International Bone & Mineral Society).

  40. Ge C, Xiao G (co-first author), Jiang D, Yang Q, Hatch NE, and Franceschi RT. Identification and functional characterization of extracellular-regulated kinase/MAPK phosphorylation sites in the Runx2 transcription factor. J Biol Chem. 2009; 284(47):32533-43. PMCID: PMC2781667.

  41. Li Y, Xiang M, Yuan Y, Xiao G, Zhang J, Vodovotz Y, Billiar TR, Wilson MA, and Fan J. HMGB1 upregulation of TLR2 augments hemorrhagic shock-Induced ICAM-1 expression in lung endothelial cells. Am J Physiol Regul Integr Comp Physiol. 2009; 297(6):R1670-80, PMCID: PMC2803625.

  42. Cao H, Yu S, Yao Z, Galson DL, Jiang Y, Zhang X, Fan J, Lu B, Guan Y, Luo M, Lai Y, Zhu, Y, Kurihara N, Patrene K, Roodman GD, Xiao G. Activating transcription factor 4 regulates osteoclast differentiation in mice. J Clin Invest. 2010 Aug 2;120(8):2755-66. PMCID: PMC2912190.

  43. Wu, Z, Jiao P, Huang, X, Feng Y, Feng B, Yang S, Hwang P, Du J, Hall RK, Xiao G, Xu H. MAP kinase phosphatase 3 regulates glucose homeostasis through dephosphorylation of FOXO1 in mice. J Clin Invest. 2010 Nov 1;120(11):3901-11. PMCID: PMC2964981.

  44. Xiang M, Yin L, Li Y, Xiao G, Vodovotz Y, Billiar TR, Wilson MA, and Fan J. Hemorrhagic shock activates lung endothelial NAD(P)H oxidase via neutrophil NADPH oxidase. Am J Respir Cell Mol Biol. 2011 Mar;44(3):333-40. PMCID: PMC3095934.

  45. Yang S, Xu H, Yu S, Cao H, Jie Fan, Ge C, Fransceschi RT, Dong HH, Xiao G. Foxo1 mediates IGF1/Insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts. J Biol Chem. 2011; 286(21):19149-58. PMCID: PMC3099728.

  46. Xiang M, Shi X, Li Y, Xu J, Yin L, Xiao G, Scott MJ, Billiar TR, Wilson MA, and Fan J. Hemorrhagic shock activation of NLRP3 inflammasome in lung endothelial cells. J Immnol. 2011; 187(9) :4809-17, PMCID: PMC3197874.

  47. Danciu TH, Li Y, Koh A, Xiao G, McCauley LK, Franceschi RT. The basic helix loop helix transcription factor Twist1 is a novel regulator of ATF4 in osteoblasts. J Cell Biochem. 2011;113(1):70-9. PMCID: PMC3414260.

  48. D'Souza S, Del Prete D, Jin S, Sun Q, Huston AJ, Kostov FE, Sammut B, Hong CS, Anderson JL, Patrene KD, Yu S, Velu CS, Xiao G, Grimes HL, Roodman GD, Galson DL. Gfi-1 expressed in bone marrow stromal cells is a novel osteoblast suppressor in patients with multiple myeloma bone disease. Blood. 2011;118(26):6871-80. PMCID: PMC3245209.

  49. Tang W, Yang F, Li Y, de Crombrugghe B, Jiao H, Xiao G, and Zhang C. Transcriptional regulation of vascular endothelial growth factor (VEGF) by osteoblast-specific transcription factor osterix (Osx) in osteoblasts. J Biol Chem. 2012 Jan 13;287(3):1671-8. PMCID: PMC3265850.

  50. Xiang M, Yuan Y, Fan L, Li Y, Li A, Yin L, Scott MJ, Xiao G, Billiar TR, Wilson MA, Fan J. Role of Macrophages in Mobilization of Hematopoietic Progenitor Cells From Bone Marrow After Hemorrhagic Shock. Shock. 2012 May;37(5):518-523. PMCID: PMC3328610.

  51. Li X, Ellman MB, Kroin JS, Chen D, Yan D, Mikecz K, Kc R, Xiao G, Stein GS, Kim SG, Cole B, van Wijnen AJ, Im HJ. Species-specific biological effects of FGF-2 in articular cartilage: Implication for distinct roles within the FGF receptor family. J Cell Biochem. 2012 Jul;113(7):2532-42. PMCID: PMC3349778.

  52. Xiao G*, Cheng H, Cao H, Chen K, Tu Y, Yu S, Jiao H, Yang S, Im HJ, Chen D, Chen J, Wu C*. Critical role of Filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling. J Biol Chem. 2012 June 15;287(25):21450-60. PMCID: PMC3375566.

  53. Ellman MB, Kim JS, An HS, Chen D, Ranjan KC, An J, Dittakavi T, van Wijnen AJ, Cs-Szabo G, Li X, Xiao G, An S, Kim SG, Im HJ. Toll-like receptor adaptor signaling molecule MyD88 on intervertebral disc homeostasis: in vitro, ex vivo studies. Gene. 2012 Sep 1;505(2):283-90, PMCID: PMC3518428.

  54. Yan D, Chen D, Xiao G, van Wijnen A, Im HJ. Bovine lactoferricin, an antimicrobial peptide, is anti-inflammatory and anti-catabolic in human articular cartilage and synovium. J Cell Physiol. 2013 Feb;228(2):447-56, PMCID: PMC3463726.

  55. Meng M, Jin H, Wang B, Yukata K, Sheu TJ, Ke QH, Tong P, Im HJ, Xiao G, Chen D. Chondrocyte BMP-2 Signaling Plays a Critical Role in Bone Fracture Healing. Gene. 512 (2013) 211–218. PMCID: PMC3531824.

  56. Yu S, Sharma R, Nie D, Jiao H, Lai Y, Fan J, Im HJ, Chen D, Wang Q, Xiao G. ADAR1 is required for osteoblast differentiation and bone homeostasis. Gene. 513 (2013) 101–110. PMCID: PMC3514579.

  57. Yu S, Zhu K, Lai Y, Zhao Z, Fan J, Im HJ, Chen D, Xiao G. ATF4 promotes β-catenin expression and osteoblastic differentiation of bone marrow mesenchymal stem cells. Int J Biol Sci. 2013; 9(3):256-266. PMCID: PMC3596711.

  58. Xu P, Wen Z, Shi X, Li Y, Fan L, Xiang M, Li A, Scott MJ, Xiao G, Li S, Billiar TR, Wilson MA, Fan J. Hemorrhagic shock augments Nlrp3 inflammasome activation in the lung through impaired pyrin induction. J Immunol. 2013 May 15;190(10):5247-55. PMCID: PMC3646900.

  59. Kim JS, Ellman MB, Yan D, An HS, Kc R, Li X, Chen D, Xiao G, Cs-Zabo G, Hoskin DW, Buechter DD, van Wijnen AJ, Im HJ. Lactoferricin mediates anti-inflammatory and anti-catabolic effects via inhibition of IL-1 and LPS activity in the intervertebral disc. J Cell Physiol. 2013 Sep;228(9):1884-96. PMCID: PMC3703102.

  60. Ellman MB, Kim J, An HS, Chen D, Kc R, Li X, Xiao G, Yan D, Suh J, van Wijnen A, Wang J, Kim S, Im H. Lactoferricin enhances BMP7-stimulated anabolic pathways in intervertebral disc cells. Gene. 2013 Jul 25;524(2):282-91. PMCID: PMC3679319.

  61. Liu Z, Jiang Y, Li Y, Wang J, Fan L, Scott MJ, Xiao G, Li S, Billiar TR, Wilson MA, Fan J. TLR4 signaling augments monocyte chemotaxis by regulating G protein-coupled receptor kinase 2 translocation. J Immunol. 2013 Jul 15;191(2):857-64. PMCID: PMC3702632.

  62. Zheng L, Zhu K, Jiao H, Zhao Z, Zhang L, Liu M, Chen D, Yao Z, Xiao G. PTHrP expression in human MDA-MB-231 breast cancer cells is critical for tumor growth and survival and osteoblast inhibition. Int J Biol Sci. 2013 Aug 21;9(8):830-41. PMCID: PMC3753447.

  63. Xiao G*, Zhang T, Yu S, Lee A, Calabuig-Navarro V, Ringquist S, Dong HH*. ATF4 deficiency protects against high fructose-induced hypertriglyceridemia in mice.  J Biol Chem. 2013 Aug 30;288(35):25350-61. PMCID: PMC3757199.

  64. Zhu K, Jiao H, Li S, Cao H, Galson DL, Zhao Z, Zhao X, Lai Y, Fan J, Im HJ, Chen D, Xiao G. ATF4 promotes bone angiogenesis by increasing VEGF expression and release in the bone environment. J Bone Miner Res.2013;28: 1870–1884. PMID: 23649506. This is an EDITOR'S CHOICE paper of September 2013 JBMR issue and highlighted with a Commentary paper ( Schipani et al. J Bone Miner Res. 2013;28:1866-1869. DOI: 10.1002/jbmr.2045).

  65. Cao H, Zhu K, Qiu L, Li S, Niu H, Hao M, Yang S, Zhao Z, Lai Y, Anderson JL, Fan J, Im HJ, Chen D, Roodman GD, Xiao G. Critical role of AKT in myeloma-induced osteoclast formation and osteolysis. J Biol Chem. 2013 Oct 18;288(42):30399-410. PMCID: PMC3798504.

  66. Yan D, Kc R, Chen D, Xiao G, Im H. Bovine lactoferricin-induced anti-inflammation is, in part, via upregulation of IL-11 by secondary activation of STAT3 in human articular cartilage. J Biol Chem. 2013 Nov 1;288(44):31655-69. PMID: 24036113.

  67. Wang B, Jin H, Zhu M, Li J, Zhao L, Zhang Y, Tang D, Xiao G, Xing L, Boyce BF, Chen D Chondrocyte β-catenin signaling regulates postnatal bone remodeling through modulation of Rankl/Opg expression and osteoclast differentiation. Arthritis Rheumatol. 2014 Jan;66(1):107-20. doi: 10.1002/art.38195. PMID: 244312822.

  68. Li TF, Yukata K, Yin G, Sheu T, Maruyama T, Jonason JH, Hsu W, Zhang X, Xiao G, Konttinen YT, Chen D, O'Keefe RJ. BMP-2 regulates chondrocyte differentiation through modulation of COX-2 and ATF4. Osteoarthritis Cartilage. 2014 Mar;22(3):481-9. PMID: 24418675.

  69. Li S, Shu B, Zhang Y, Li J, Guo J, Wang Y, Ren F, Xiao G, Chang Z, Chen D. CHIP regulates osteoclast formation through promoting TRAF6 protein degradation. Arthritis Rheumatol. 2014 Jul;66(7):1854-63. doi: 10.1002/art.38521. PMID: 24578159.

  70. Xu J, Jiang Y, Wang J, Shi X, Liu Q, Liu Z, Li Y, Scott MJ, Xiao G, Li S, Fan L, Billiar TR, Wilson MA, Fan J. Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis. Cell Death Differ. 2014 Aug;21(8):1229-39. PMID: 24769733. PMCID: PMC4085529.

  71. Qu H, Tu Y, Guan JL, Xiao G, Wu C. Kindlin-2 tyrosine phosphorylation and interaction with Src serve as a regulatable switch in the integrin outside-in signaling circuit. J Biol Chem. 2014 Nov 7;289(45):31001-13. PMID: 2523719.

  72. Wen Z, Fan L, Li Y, Zou Z, Scott MJ, Xiao G, Li S, Billiar TR, Wilson MA, Shi X, Fan J. Neutrophils counteract autophagy-mediated anti-inflammatory mechanisms in alveolar macrophage: role in posthemorrhagic shock acute lung inflammation. J Immunol. 2014 Nov 1;193(9):4623-33. PMID: 25267975.

  73. Niu NK, Wang ZL, Pan ST, Ding HQ, Au GHT, He ZX, Zhou ZW, Xiao G, Yang YX, Zhang X, Yang T, Chen XW, Qiu JX, Zhou SF. Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway. Drug Des Devel Ther. 2015 Mar 12;9:1555-84. PMID: 25792811.

  74. Zhu K, Yi J, Xiao Y, Lai Y, Song P, Zheng W, Jiao H, Fan J, Wu C, Chen D, Zhou J, Xiao G. Impaired bone homeostasis in amyotrophic lateral sclerosis mice with muscle atrophy. J Biol Chem. 2015 Mar 27;290(13):8081-94. doi: 10.1074/jbc.M114.603985. Epub 2015 Feb 3. PMID: 25648889.

  75. Wu C, Jiao H, Lai Y, Zheng W, Chen K, Deng W, Song P, Zhu K, Cao H, Galson DL, Fan J, Im HJ, Liu Y, Chen J, Chen D, Xiao G. Kindlin-2 controls TGF-β signaling and Sox9 expression to regulate chondrogenesis. Nat Commun. 2015 Jul 7;6:7531. doi: 10.1038/ncomms8531. PMID: 26151572.

  76. Kim JS, Ahmadinia K, Li X, Hamilton JL, Andrews S, Haralampus CA, Xiao G, Sohn HM, You JW, Seo YS, Stein GS, Van Wijnen AJ, Kim SG, Im HJ. Development of an experimental animal model for lower back pain by percutaneous injury-induced lumbar facet joint osteoarthritis. J Cell Physiol. 2015 Nov;230(11):2837-47. doi: 10.1002/jcp.25015. PMID: 25858171.

  77. Qin TT, Xu GC, Qi JW, Yang GL, Zhang K, Liu HL, Xu LX, Xiang R, Xiao G, Cao H, Wei Y, Zhang QZ, Li LY. Tumor necrosis factor superfamily member 15 (Tnfsf15) facilitates lymphangiogenesis via upregulation of Vegfr3 gene expression in lymphatic endothelial cells. J Pathol. 2015 Nov;237(3):307-18. doi: 10.1002/path.4577. Epub 2015 Aug 6. PMID: 26096340.

  78. Zhao Y, Zhou J, Liu D, Dong F, Cheng H, Wang W, Pang Y, Wang Y, Mu X, Ni Y, Li Z, Xu H, Hao S, Wang X, Ma S, Wang QF, Xiao G, Yuan W, Liu B, Cheng T. ATF4 plays a pivotal role in the development of functional hematopoietic stem cells in mouse fetal liver. Blood. 2015 Nov 19;126(21):2383-91. doi: 10.1182/blood-2015-03-633354. Epub 2015 Sep 17. PMID: 26384355.

  79. Kim JS, Ali MH, Wydra F, Li X, Hamilton JL, An HS, Cs-Szabo G, Andrews S, Moric M, Xiao G, Wang JH, Chen D, Cavanaugh JM, Im HJ. Characterization of degenerative human facet joints and facet joint capsular tissues. Osteoarthritis Cartilage. 2015 Dec;23(12):2242-51. PMID: 26117175, PMCID: PMC4663154.

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  150. Lu K, Wang Q, Hao L, Wei G, Wang T, Xiao G, Tong L, Zhao X, Chen D. miR-204 ameliorates osteoarthritis pain by inhibiting SP1-LRP1 signaling and blocking neuro-cartilage interaction. Bioact Mater. 2023 Mar 20;26:425-436. doi: 10.1016/j.bioactmat.2023.03.010. eCollection 2023 Aug. PMID: 36969105.

  151. Chen S, He T, Zhong Y, Chen M, Yao Q, Chen D, Shao Z, Xiao G. Roles of focal adhesion proteins in skeleton and diseases. Acta Pharm Sin B. (ASPB) 2023 Mar;13(3):998-1013. doi: 10.1016/j.apsb.2022.09.020. Epub 2022 Oct 3. PMID: 36970189.

  152. Lu K, Wang Q, Jiang H, Li J, Yao Z, Huang Y, Chen J, Zhang J, Xiao G, Hu X, Luo Z, Yang L, Tong L, Chen D.Upregulation of b-catenin signaling represents a single, common pathway leading to the various phenotypes of spinal degeneration and pain. Bone Res. 2023 Apr 14;11(1):18. doi: 10.1038/s41413-023-00253-0. PMID: 37059724.

  153. Yao Q, Gong W, Wu X, Gan D, Tao C, Lin S, Qu M, Ouyang Z, Chen M, Hu X, Xiao G. Comparison of Kindlin-2 deficiency-stimulated osteoarthritis-like lesions induced by Prg4CreERT2 versus AggrecanCreERT2 transgene in mice. J Orthop Translat. 2023 May 31;41:12-19.  doi: 10.1016/j.jot.2023.05.005.  eCollection 2023 Jul. MID:37292436, PMCID: PMC10244901, DOI: 10.1016/j.jot.2023.05.005.

  154. Qin L, Chen Z, Yang D, He T, Xu Z, Zhang P, Yi W, Xiao G. Osteocyte b3 integrin promotes bone mass accrual and force-induced bone formation in adult mice. J Orthop Translat. 2023 Jun 7;40:58-71. doi: 10.1016/j.jot.2023.05.001. eCollection 2023 May. PMID: 37457310

  155. Xie X, Zhang W, Xiao M, Qiu J, Wang H, Qiu Z, Zhang S, Mao L, Wei T, Li Y, Hu S, Pan Y, Chen Z, Li L, Lu Y, Gong Y, Yang J, Xiao G*, Zhang Y*, Bai X*. TREM2 acts as a receptor for IL-34 to suppress acute myeloid leukemia. Blood. 2023 Jun 29;141(26):3184-3198. doi: 10.1182/blood.2022018619. PMID: 37001042   

  156. Gao H, Zhong Y, Lin S, Yan Q, Yao Q, Zou X, Xiao G. Adipoq+ cell population controls bone mass via sclerostin in the bone microenvironment in mice. Signal Transduct Target Ther (STTT). 2023 Jul 10;8(1):265. doi: 10.1038/s41392-023-01461-0. PMID: 37423945. Paper of the Month - January 2024 selected by the BMAS Scientific Board (https://bma-society.org/paper-of-the-month/)

  157. Wu X, Chen M, Lin S, Chen S, Gu J, Wu Y, Qu M, Gong W, Yao Q, Li H, Zou X, Chen D, Xiao G. Loss of Pinch Proteins Causes Severe Degenerative Disc Disease-Like Lesions in Mice. Aging Dis. 2023 Oct 1;14(5):1818-1833. doi: 10.14336/AD.2023.0212. PMID: 37196110

  158. Yi D, Jin H, Lu WW, Zhang C, Xiao G, Tong L, Chen D, Deletion of Axin1 in aggrecan-expressing cells leads to growth plate cartilage defects in adult mice. Genes & Diseases. https://doi.org/10.1016/j.gendis.2023.101147.

  159. Chen S, Yang W, Chen M, Liu S, Shao Z, Xiao G. Regulated cell death in musculoskeletal formation, homeostasis, and diseases. Fundamental Research (2023).doi: https://doi.org/10.1016/j.fmre.2023.08.009

  160. Lu K, Zhang M, Wei G, Xiao G, Tong L, Chen D. Multiple cullin-associated E3 ligases regulate cyclin D1 protein stability. Elife. 2023 Nov 9;12:e80327. doi: 10.7554/eLife.80327. Online ahead of print. PMID: 37943017

  161. Aging Biomarker Consortium, Jinlong Suo, Yibo Gan, Yangli Xie, Shuqin Xu, Jianfang Wang, Di Chen, Lin Chen, Lianfu Deng, Shiqing Feng, Jingdong Jackie Han, Qing Jiang, Guanghua Lei, Peng Liu, Xianghang Luo, Xin Ma, Jing Qu, Chunli Song, Peifu Tang, Tingting Tang, Sijia Wang, Xiaochun Wei, Chengtie Wu, Guozhi Xiao*, Liu Yang, Licheng Zhang, Weiqi Zhang, Zhenlin Zhang, Guang-Hui Liu, Changqing Zhang, Gang Pei, Jian Luo, Rui Yue, Weiguo Zou, A framework of biomarkers for skeletal aging: a consensus statement by the Aging Biomarker Consortium. Life Medicine, 2023; lnad045, https://doi.org/10.1093/lifemedi/lnad045

  162. Li J, Liu B, Wu H, Zhang S, Liang Z, Guo S, Jiang H, Song Y, Lei X, Gao Y, Cheng P, Li D, Wang J, Liu Y, Wang D, Zhan N, Xu J, Wang L, Xiao G, Yang L, Pei G. Sensory nerves directly promote osteoclastogenesis by secreting Peptidyl-prolyl cis-trans isomerase D (Cyp40). Bone Res. 2023 Dec 14;11(1):64. doi: 10.1038/s41413-023-00300-w. PMID: 38097598

  163. Gan D, Tao C, Jin X, Jia Q, Wu X, Yan Q, Zhong Y, Wu L, Huo S, Xiao G. Piezo1 activation accelerates osteoarthritis progression and the targeted therapy effect of artemisinin. J Adv Res. 2023 Sep 25:S2090-1232(23)00289-8. doi: 10.1016/j.jare.2023.09.040. Online ahead of print. PMID: 37758057

  164. Gan D, Jin X, Wang X, Tao C, Yan Q, Jia Q, Huo S, Chen D, Yao Q, Xiao G. Pathological progress and remission strategies of osteoarthritic lesions caused by long-term joint immobilization. Arthritis Res Ther. 2023 Dec 7;25(1):237. doi: 10.1186/s13075-023-03223-3.PMID: 38062473

  165.  He T, Zhou B, Cheng H, Yan Q, Lin S, Ma G, Yao Q, Wu X, Zhong Y, Gan D, Huo S, Jin W, Chen D, Bai X, Cheng T, Cao H, Xiao G. The bone-liver interaction modulates immune and hematopoietic function through Pinch-Cxcl12-Mbl2 pathway. Cell Death Differ. 2024 Jan;31(1):90-105. doi: 10.1038/s41418-023-01243-9. Epub 2023 Dec 7.

  166. Liao Z, Umar M, Huang X, Qin L, Xiao G, Chen Y, Tong L, Chen D. Transient receptor potential vanilloid 1: A potential therapeutic target for the treatment of osteoarthritis and rheumatoid arthritis. Cell Prolif  2023 Nov 23:e13569.  doi: 10.1111/cpr.13569.  Online ahead of print

  167. Qin L, Xiao G. Primary astrocytes purification and immortalization. Curr Protoc. 2023 Dec;3(12):e964. doi: 10.1002/cpz1.964. PMID: 38131300

  168. Lin S, Tao C, Yan Q, Gao H, Qin L, Zhong Y, Yao Q, Zhang P, Zou X, Xiao G. Pip5k1c expression in osteocytes regulates bone remodeling in mice. J Orthop Translat  (accepted)

  169.  Changyuan Huang; Bin Zeng; Bo Zhou; Guanming Chen; Qi Zhang; Wenhong Hou; Guozhi Xiao; Li Duan; Ni Hong; Wenfei Jin. Single cell transcriptomic analysis of chondrocytes in cartilage and pathogenesis of osteoarthritis. Genes & Diseases (in press)

  170. Dan Yi, Rong Xie, Daofu Zeng, Jun Xiao, Guozhi Xiao, Hongting Jin, Liping Tong, Di Chen. Loss of Axin1 in limb mesenchymal cells leads to multiple synostoses syndrome-like phenotype in mice. The Innovation Medicine (in press).

  171. Zhong Y, Zhou L, Wang H, Lin S, Liu T, Kong X, Xiao G*, Gao H*. Kindlin-2 loss in hepatocytes causes liver dysfunction by stimulating oxidative stress and osteopontin-dependent inflammation in mice. J Biol Chem. 2023 Dec 28:105601. doi: 10.1016/j.jbc.2023.105601. Online ahead of print. PMID: 38159860



  近几年实验室获奖：

· Guozhi Xiao, ASBMR (American Society for Bone and Mineral Research) Annual Meeting, Travel Award, 1996

· Guozhi Xiao, ASBMR Young Investigator Award, 1998

· Shibing Yu, 5th Research Day, Department of Medicine, University of Pittsburgh, First Award of Post-Doc Fellow Category, 2007

· 曹惠玲, 教育部博士论文百优提名, 2010

· Huiling Cao, ICBMR/IOS (9th International Conference on Bone and Mineral Research (ICBMR) & 11th International Osteoporosis Symposium) Young Investigator Award, 2011

· Huiling Cao, ASBMR Young Investigator Award, 2011

· Guozhi Xiao, International Chinese Musculoskeletal Research Conference (ICMRC), Best Poster Presentation Award, 2013

· Shibing Yu, ASBMR Travel Award, Plenary Poster, 2013

· Ke Zhu, ASBMR Travel Award, Plenary Poster, 2014

· Huiling Cao, ASBMR Travel Award, Plenary Poster, 2016

· Xin Liu, ASBMR Travel Award, Plenary Poster, 2017

· Xin Liu, ICMRS, First Young Investigator Prize, oral presentation, 2017

· Huiling Cao, ICMRS, First Young Investigator Prize, oral presentation, 2017

· Huiling Cao, ASBMR, Plenary Poster, 2017

· Huiling Cao, ICMRS Webster Jee Travel Award, 2018

· Yishu Wang, ASBMR Young Investigator Award, Oral Presentation, 2019

· 王依姝，博士研究生国家奖学金, 2019

· Yiming Lei, ASBMR Education Emerging Country Young Investigator Award，2019

· Yiming Lei, ICMRS, Third Young Investigator Prize, oral presentation, 2019

· Lei Qin, ICMRS, First Young Investigator Prize, oral presentation, 2019

· 刘鑫, 校十佳毕业生候选人，校级优秀毕业生, 2019

· 郭禺熙, 生物系优秀毕业生, 2020

· 李茹璇, 校十佳毕业生候选人, 校级优秀毕业生, 2020

· 李鹏宇, 生物系优秀毕业生, 2020

· 肖国芝，南方科技大学，年度教授奖, 2020

· 曹惠玲, 国自然优秀青年基金获得者, 2020

· Lei Qin, ASBMR Young Investigator Award, 2021

· Xiaohao Wu, ASBMR Felix Bronner Young Investigator Award; the highest ranking abstract, 2021

· Xiaohao Wu, ICMRS Webster Jee Young Investigator Award, 2021

· 陈明珏，硕士研究生国家奖学金，2021

· 高焕庆，首届南方科技大学医学系统学术年会，一等奖， 2021

· 吴晓昊，首届南方科技大学医学系统学术年会，三等奖， 2021

· 陈胜，首届南方科技大学医学系统学术年会，优秀奖，2021

· 姚青, 国自然面上基金, 53万，2022

· 河泰麟，南方科技大学医学院，优秀博士生，2022

· 陈明珏，南方科技大学医学院，优秀研究生，2022

· 钟一鸣，南方科技大学医学院“院长奖”，2022

· 河泰麟，南方科技大学医学院2021度优秀研究生，2022

· 钟一鸣，南方科技大学校级硕士学位论文，2022

· 钟一鸣，南方科技大学校级优秀研究生毕业生，2022

· 钟一鸣，南方科技大学2022年研究生“十佳毕业生”

· 甘东浩，教育部博士后基金, 8万，2022

· 陈明珏, ICMRS Webster Jee Young Investigator Award, 2022