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南科大医学院
官方公众号

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Baotong Zhang

Assistant Professor

0755-88010102

zhangbt@sustech.edu.cn

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个人简介

Baotong Zhang is a tenure-track Assistant Professor and Doctoral Supervisor at Southern University of Science and Technology School of Medicine. Dr. Zhang graduated from Nankai University with his Ph. D. degree in Genetics in 2014. He was a postdoctoral fellow from 2014 to 2020 and then promoted as an Instructor in the Department of Hematology and Medical Oncology at Emory University School of Medicine. He joined SUStech in 2021. Dr. Zhang has authored 24 research articles in high-profile journals (i.e., Nature Communications, Cell Metabolism, Theranostics, Molecular Cancer, Molecular and Cellular Biology, etc.) with 700+ citations. His achievement in prostate cancer bone metastasis won the AACR 2020 Scholar-in-Training Award. Dr. Zhang’s primary research focus is the genetic determinants of cancer metastasis, especially in prostate cancer. He is an ad-hoc reviewer of many journals, including Journal of Molecular Cell Biology, International Journal of Cancer, Journal of Genetics and Genomics, Scientific Reports, and Cancers. He is also on the editorial board of Frontiers in Cell and Developmental Biology，Biomed Research International, Experimental and Therapeutic Medicine.


研究领域

1. Genetic determinants of cancer metastasis.

2. Microenvironment of cancer metastasis.

3. Drug resistance of cancer metastasis.

4. Prostate development and tumorigenesis.


教育背景

2009.9 ~ 2014.6: Ph.D. major in Genetics, Nankai University, Tianjin, China; (Mentor: Dr. Jin-Tang Dong)

2005.9 ~ 2009.6: B.Sc. major in Biological Sciences, Nankai University, Tianjin, China;

 


工作经历

2020.12~2021.7: Instructor

Department of Hematology and Medical Oncology, Emory University School of Medicine, Winship Cancer Institute, Atlanta, Georgia

2014.9 ~ 2020.11: Postdoctoral Fellow

Department of Hematology and Medical Oncology, Emory University School of Medicine, Winship Cancer Institute, Atlanta, Georgia

(Mentor: Drs. Jin-Tang Dong and Wei Zhou)               

 


获奖情况及荣誉

2008      China National Scholarship (Top 0.2%), Ministry of Education of the People's Republic of China

2020      AACR Scholar-in-Training Award

 


杂志编委会成员

2021.06 - Present，Guest Associate Editor, Frontiers in Cell and Developmental Biology

2020.07 - Present，Academic Editor, Biomed research international

2021.05 - Present，Editor Board Member, Experimental and Therapeutic Medicine


近年代表文章

  1. Baotong Zhang,      Yixiang Li, Qiao Wu, Lin Xie, Benjamin Barwick, Changying Fu, Xin Li,      Daqing Wu, Siyuan Xia, Jing Chen, Wei Ping Qian, Lily Yang, Adeboye O.      Osunkoya, Lawrence H. Boise, Paula M. Vertino, Yichao Zhao, Menglin Li,      Hsiao-Rong Chen, Jeanne Kowalski, Omer Kucuk, Wei Zhou & Jin-Tang      Dong. Acetylation of KLF5 maintains EMT and tumorigenicity to cause      chemoresistant bone metastasis in prostate cancer. Nature communications      12,      doi:10.1038/s41467-021-21976-w      (2021).

  2. Baotong Zhang,      Xinpei Ci, Ran Tao, Jianping Jenny Ni, Xiaoyan Xuan, Jamie L. King, Siyuan      Xia, Yixiang Li, Henry F. Frierson, Dong-Kee Lee, Jianming Xu, Adeboye O.      Osunkoya & Jin-Tang Dong. Klf5 acetylation regulates luminal      differentiation of basal progenitors in prostate development and regeneration.      Nature      communications 11, doi:10.1038/s41467-020-14737-8 (2020). (This      article is featured by Nature Communications in https://www.nature.com/collections/pkgztbmgly)

  3. Yixiang Li, Baotong Zhang#, Lingwei      Xiang, Siyuan Xia, Omer Kucuk, Xingming Deng, Lawrence H. Boise &      Jin-Tang Dong#. TGF-beta causes Docetaxel resistance in      Prostate Cancer via the induction of Bcl-2 by acetylated KLF5 and Protein      Stabilization. Theranostics 10, 7656-7670, doi:10.7150/thno.44567 (2020).      (# co-corresponding author)

  4. Qiao Wu, Changying Fu, Menglin Li, Juan Li, Zhigui Li,      Leilei Qi, Xinpei Ci, Gui Ma, Ang Gao, Xing Fu, Na An, Mingcheng Liu,      Yixiang Li, Jamie L King, Liya Fu, Baotong Zhang# &      Jin-Tang Dong#. CINP is a novel cofactor of KLF5 required for      its role in the promotion of cell proliferation, survival and tumor      growth. International journal of cancer 144, 582-594 (2019). doi:      10.1002/ijc.31908. Epub 2018 Oct 26. (# co-corresponding author)

  5. Ran Tao*, Baotong Zhang*,      Yixiang Li, Jamie L. King, Ruoyu Tian, Siyuan Xia, Cara R. Schiavon &      Jin-Tang Dong. HDAC-mediated deacetylation of KLF5 associates with its      proteasomal degradation. Biochemical and Biophysical Research      Communications 500, 777-782, doi:10.1016/j.bbrc.2018.04.153      (2018). (* co-first author)

  6. Baotong Zhang*, Ranran      Zhao*, Yuan He, Xing Fu, Liya Fu, Zhengmao Zhu, Li Fu &      Jin-Tang Dong. MicroRNA 100 sensitizes luminal A breast cancer cells to      paclitaxel treatment in part by targeting mTOR. Oncotarget 7,      5702-5714, doi:10.18632/oncotarget.6790 (2016). (* co-first author)

  7. Baotong Zhang,      Zhiqian Zhang, Siyuan Xia, Changsheng Xing, Xinpei Ci, Xin Li, Ranran      Zhao, Sha Tian, Gui Ma, Zhengmao Zhu, Liya Fu & Jin-Tang Dong. KLF5      activates microRNA 200 transcription to maintain epithelial      characteristics and prevent induced epithelial-mesenchymal transition in      epithelial cells. Molecular and Cellular Biology      33, 4919-4935, doi:10.1128/MCB.00787-13 (2013).

  8. Jun A, Baotong Zhang, Zhiqian Zhang, Hailiang Hu &      Jin-Tang Dong. Novel Gene Signatures Predictive of Patient Recurrence-Free      Survival and Castration Resistance in Prostate Cancer. Cancers      13, doi:10.3390/cancers13040917 (2021).

  9. Ge Dong, Gui Ma, Rui      Wu, Jinming Liu, Mingcheng Liu, Ang Gao, Xiawei Li, Jun A, Xiaoyu Liu,      Zhiqian Zhang, Baotong Zhang, Liya Fu & Jin-Tang Dong. ZFHX3      Promotes the Proliferation and Tumor Growth of ER-Positive Breast Cancer      Cells Likely by Enhancing Stem-Like Features and MYC and TBX3      Transcription. Cancers 12, doi:10.3390/cancers12113415      (2020).

  10. Rui Wu, Jiali Fang, Mingcheng Liu, Jun A, Jinming Liu,      Wenxuan Chen, Juan Li, Gui Ma, Zhiqian Zhang, Baotong Zhang, Liya      Fu & Jin-Tang Dong. SUMOylation of the transcription factor ZFHX3 at      Lys-2806 requires SAE1, UBC9, and PIAS2 and enhances its stability and      function in cell proliferation. Journal of Biological Chemistry 295,      6741-6753, doi:10.1074/jbc.RA119.012338 (2020).

  11. Juan Li, Baotong Zhang, Mingcheng Liu, Xing Fu,      Xinpei Ci, Jun A, Changying Fu, Ge Dong, Rui Wu, Zhiqian Zhang, Liya Fu      & Jin-Tang Dong. KLF5 Is Crucial for Androgen-AR Signaling to      Transactivate Genes and Promote Cell Proliferation in Prostate Cancer      Cells. Cancers (Basel) 12, doi:10.3390/cancers12030748 (2020).

  12. Changying Fu, Na An, Jinming Liu, Jun A, Baotong      Zhang, Mingcheng Liu, Zhiqian Zhang, Liya Fu, Xinxin Tian, Dan Wang      & Jin-Tang Dong. The transcription factor ZFHX3 is crucial for the      angiogenic function of hypoxia-inducible factor 1alpha in liver cancer      cells. Journal of Biological Chemistry 295, 7060-7074,      doi:10.1074/jbc.RA119.012131 (2020).

  13. Gui Ma, Ang Gao, Yinan Yang, Yuan He, Xi Zhang, Baotong      Zhang, Zhiqian Zhang, Mei Li, Xing Fu, Dan Zhao, Rui Wu, Leilei Qi,      Qingxia Hu, Juan Li, Liya Fu, Zhengmao Zhu & Jin-Tang Dong. Zfhx3 is      essential for progesterone/progesterone receptor signaling to drive ductal      side-branching and alveologenesis in mouse mammary glands. Journal      of Genetics and Genomics (2019).

  14. Qingxia Hu, Baotong Zhang, Rui Chen, Changying      Fu, A Jun, Xing Fu, Juan Li, Liya Fu, Zhiqian Zhang & Jin-Tang Dong.      ZFHX3 is indispensable for ERβ to inhibit cell proliferation via MYC      downregulation in prostate cancer cells. Oncogenesis 8, 28      (2019).

  15. Xinxin Tian, Fangfang Tao, Baotong Zhang,      Jin-Tang Dong & Zhiqian Zhang. The miR-203/SNAI2 axis regulates      prostate tumor growth, migration, angiogenesis and stemness potentially by      modulating GSK-3beta/beta-CATENIN signal pathway. IUBMB Life 70,      224-236, doi:10.1002/iub.1720 (2018).

  16. Jamie L. King, Baotong Zhang, Yixiang Li, Kathy      P. Li, Jianping J. Ni, Harold I. Saavedra & Jin-Tang Dong. TTK      promotes mesenchymal signaling via multiple mechanisms in triple negative      breast cancer. Oncogenesis 7, 69, doi:10.1038/s41389-018-0077-z (2018).

  17. Siyuan Xia, Ruiting Lin, Lingtao Jin, Liang Zhao,      Hee-Bum Kang, Yaozhu Pan, Shuangping Liu, Guoqing Qian, Zhiyu Qian,      Evmorfia Konstantakou, Baotong Zhang, Jin-Tang Dong, Young R.      Chung, Omar Abdel-Wahab, Taha Merghoub, Lu Zhou, Ragini R. Kudchadkar,      David H. Lawson, Hanna J. Khoury, Fadlo R. Khuri, Lawrence H. Boise, Sagar      Lonial, Benjamin H. Lee, Brain P. Pollack, Jack L. Arbiser, Jun Fan,      Qun-Ying Lei & Jing Chen. Prevention of Dietary-Fat-Fueled Ketogenesis      Attenuates BRAF V600E Tumor Growth. Cell Metabolism 25, 358-373,      doi:10.1016/j.cmet.2016.12.010 (2017).

  18. Leilei Qi, Baotong Zhang, Shiying Zhang, Xinpei      Ci, Qiao Wu, Gui Ma, Ang Luo, Liya Fu, Jamie L. King, Rita Nahta &      Jin-Tang Dong. ERRF sensitizes ERBB2-positive breast cancer cells to lapatinib      treatment likely by attenuating MCL1 and ERBB2 expression. Oncotarget      8, 36054-36066, doi:10.18632/oncotarget.16425 (2017).

  19. Xiaodong Sun, Changsheng Xing, Xiaoying Fu, Jie Li, Baotong      Zhang, Henry F. Frierson, Jr. & Jin-Tang Dong. Additive Effect of      Zfhx3/Atbf1 and Pten Deletion on Mouse Prostatic Tumorigenesis. Journal      of Genetics and Genomics 42, 373-382,      doi:10.1016/j.jgg.2015.06.004 (2015).

  20. Xin Li, Baotong Zhang, Qiao Wu, Xinpei Ci, Ranran      Zhao, Zhiqian Zhang, Siyuan Xia, Dan Su, Jie Chen, Gui Ma, Liya Fu &      Jin-Tang Dong. Interruption of KLF5 acetylation converts its function from      tumor suppressor to tumor promoter in prostate cancer cells. International      journal of cancer 136, 536-546, doi:10.1002/ijc.29028 (2015).

  21. Xinpei Ci, Changsheng Xing, Baotong Zhang,      Zhiqian Zhang, Jenny J. Ni, Wei Zhou & Jin-Tang Dong. KLF5 inhibits      angiogenesis in PTEN-deficient prostate cancer by attenuating AKT      activation and subsequent HIF1alpha accumulation. Molecular Cancer 14,      91, doi:10.1186/s12943-015-0365-6 (2015).

  22. Zhiqian Zhang, Zhengmao Zhu, Baotong Zhang,      Weidong Li, Xin Li, Xiao Wu, Lijuan Wang, Liya Fu, Li Fu & Jin-Tang      Dong. Frequent mutation of rs13281615 and its association with PVT1      expression and cell proliferation in breast cancer. Journal of Genetics and      Genomics 41, 187-195, doi:10.1016/j.jgg.2014.03.006 (2014).

  23. Mei Li, Dan Zhao, Gui Ma, Baotong Zhang, Xiaoying      Fu, Zhengmao Zhu, Liya Fu, Xiaodong Sun & Jin-Tang Dong. Upregulation      of ATBF1 by progesterone-PR signaling and its functional implication in      mammary epithelial cells. Biochemical and Biophysical Research      Communications 430, 358-363, doi:10.1016/j.bbrc.2012.11.009      (2013).

  24. Zhiqian Zhang, Baotong Zhang, Weidong Li, Liya      Fu, Li Fu, Zhengmao Zhu & Jin-Tang Dong. Epigenetic Silencing of      miR-203 Upregulates SNAI2 and Contributes to the Invasiveness of Malignant      Breast Cancer Cells. Genes & cancer 2, 782-791,      doi:10.1177/1947601911429743 (2011).