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南科大医学院
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Liu Quan

Associate Professor，Doctoral Supervisor

0755-88018055

liuq3@sustech.edu.cn

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个人简介

Quan Liu, M.D., Ph.D., is an associate professor in the School of Medicine at SUSTech as well as a junior attending surgeon. Dr. Liu achieved his Medical Degree from Harbin Medical University (HMU) in 2002. He received his surgical training at the Second Affiliated Hospital of HMU from late 2002 through 2008 and specialized in cardiothoracic surgery. Dr. Liu moved forward for his Ph.D. degree and spent over 8 years (from 2009 to 2017) at the University of Pittsburgh. He studied transplantation immunobiology, inflammation regulation, and immunobiology of IL-33 and regulatory T cells (Treg) in the Thomas E. Starzl Transplantation Institute at the University of Pittsburgh with Drs. Heth Turnquist and Adrian Morelli.

研究领域

1. Alloantigen presentation

2. Immunobiology of IL-33, Treg and ILC2 in settings of transplantation, inflammation regulation and tumor

3. Immunotherapy


教育背景

09.1997-06.2002, Clinical medicine, Undergraduate college, Haerbin Medical University

09.2002-06.2005, Surgery, Master, Haerbin Medical University

09.2008-12.2011, Surgery, Doctor, Haerbin Medical University

02.2009-08.2009, Clinical heart/lung transplantation observation,  Presbyterian Hospital, University of Pittsburgh Medical Center, USA

12.2009-03.2012, Research fellow, T.E. Starzl Transplantation Institute, University of Pittsburgh, USA

03.2012-02.2014, Postdoctor, T.E. Starzl Transplantation Institute, University of Pittsburgh, USA


工作经历

2018.08-present, Associate Professor, School of Medicine, Southern University of Science and Technology

03.2014-04.2017,  Research Associate， T.E. Starzl Transplantation Institute, University of Pittsburgh, USA

09.2014-08.2018, Deputy Chief Physician, Cardiovascular Surgery, The Second Affiliated Hospital of Harbin Medical University, China

09.2008-08.2014, Attending Physician, Cardiovascular Surgery, The Second Affiliated Hospital of Harbin Medical University, China

07.2005-08.2008, Resident, Cardiovascular Surgery, The Second Affiliated Hospital of Harbin Medical University, China


近年代表文章

  1.  Li T, Zhang Z, Bartolacci JG, Dwyer GK , Liu Q, Mathews L, Velayutham M, Roessing A, Lee YC, Dai H, Shiva S, Oberbarnscheidt MH, Dziki JL, Mullett SJ, Wendell SG, Wilkinson JD, Webber SA, Wood-Trageser MA, Watkins SC, Demetris AJ, Hussey GS, Badylak SF, Turnquist HR. Graft IL-33 regulates infiltrating macrophages to protect against chronic rejection. J Clin Invest. 2020;130:5397-5412.（Nature Index 期刊，影响因子14.808）

  2. Qiang Du, Jing Luo, Mu-Qing Yang, Quan Liu, Caroline Heres, Yi-He Yan, Donna Stolz, David A Geller. iNOS/NO is required for IRF1 activation in response to liver ischemia-reperfusion in mice. Mol Med. 2020;26:56. 

  3. Xiao F, Lin L, Chao Z, Shao C, Chen Z, Wei Z, Lu J, Huang Y, Li L, Liu Q, Liang Y, Tian L. Organic Spherical Nucleic Acids for the Transport of a NIR-II-Emitting Dye Across the Blood–Brain Barrier. Angew Chem Int Ed Engl. 2020; 59:9702-9710. (Nature Index 期刊，影响因子15.336)

  4. Lin L, Li Y, Liu M, Li Q, Liu Q#, Li R#. The Interleukin-33/ST2 axis promotes glioma mesenchymal transition, stemness and TMZ resistance via JNK activation. Aging. 2020;12:1685-1703. （#共同通讯作者，影响因子5.682）

  5. Liu Q, Dwyer GK, Zhao Y, Li H, Mathews LR, Chakka AB, Chandran UR, Demetris JA, Alcorn JF, Robinson KM, Ortiz LA, Pitt BR, Thomson AW, Fan MH, Billiar TR, Turnquist HR. IL-33-mediated IL-13 secretion by ST2+ Tregs controls inflammation after lung injury. JCI Insight. 2019;4(6). pii: 123919. （影响因子8.315）

  6. Liu Q, Rojas-Canales DM, Divito SJ, Shufesky WJ, Stolz DB, Erdos G, Sullivan ML, Gibson GA, Watkins SC, Larregina AT, Morelli AE. Donor dendritic cell-derived exosomes promote allograft-targeting immune response. J Clin Invest. 2016;126:2805-20. （Nature Index 期刊，影响因子14.808，高被引论文）

  7. Zhuang Q*, Liu Q*, Divito SJ, Zeng Q, Yatim KM, Hughes AD, Rojas-Canales DM, Nakao A, Shufesky WJ, Williams AL, Humar R, Hoffman RA, Shlomchik WD, Oberbarnscheidt MH, Lakkis FG, Morelli AE. Graft-infiltrating host dendritic cells play a key role in organ transplant rejection. Nat Commun. 2016;7:12623. （*共同第一作者，Nature Index 期刊，影响因子14.919）

  8. Liu Q, Wang Y, Nakao A, Zhang W, Gorantla V, Zheng XX. Heart allograft tolerance induced and maintained by vascularized hind-limb transplant in rats. Clin Dev Immunol. 2013; 2013:483856.

  9. Matta BM, Reichenbach DK, Zhang X, Mathews L, Koehn BH, Dwyer GK, Lott JM, Uhl FM, Pfeifer D, Feser CJ, Smith MJ, Liu Q, Zeiser R, Blazar BR, Turnquist HR. Peri-alloHCT IL-33 administration expands recipient T regulatory cells that protect mice against acute GVHD. Blood. 2016;128:427-39. (影响因子22.113)

  10. Reichenbach DK, Schwarze V, Matta BM, Tkachev V, Lieberknecht E, Liu Q, Koehn BH1, Pfeifer D, Taylor PA, Prinz G, Dierbach H, Stickel N, Beck Y, Warncke M, Junt T, Schmitt-Graeff A, Nakae S, Follo M, Wertheimer T, Schwab L, Devlin J, Watkins SC, Duyster J, Ferrara JL, Turnquist HR, Zeiser R, Blazar BR. The IL-33/ST2 axis augments effector T-cell responses during acute GVHD. Blood. 2015;125:3183-92. (影响因子22.113)

  11. Xu J, Jiang Y, Wang J, Shi X, Liu Q, Liu Z, Li Y, Scott MJ, Xiao G, Li S, Fan L, Billiar TR, Wilson MA, Fan J. Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis. Cell Death Differ. 2014;21:1229-39. (影响因子15.828)

  12. Rosborough BR, Raïch-Regué D, Liu Q, Venkataramanan R, Turnquist HR, Thomson AW. Adenosine triphosphate-competitive mTOR inhibitors: a new class of immunosuppressive agents that inhibit allograft rejection. Am J Transplant. 2014;14:2173-80. (影响因子8.086)

  13. Matta BM, Lott JM, Mathews LR, Liu Q, Rosborough BR, Blazar BR, Turnquist HR. IL-33 is an unconventional alarmin that stimulates IL-2 secretion by dendritic cells to selectively expand IL-33R/ST2+ regulatory T cells. J Immunol. 2014;193:4010-20.

  14. Rosborough BR, Mathews LR, Matta BM, Liu Q, Raïch-Regué D, Thomson AW, Turnquist HR.Cutting edge: Flt3 ligand mediates STAT3-independent expansion but STAT3-dependent activation of myeloid-derived suppressor cells. J Immunol. 2014;192:3470-3.

  15. Du Q, Zhang X, Liu Q, Zhang X, Bartels C, Geller DA. Nitric Oxide Production Upregulates Wnt/β-catenin Signaling By Inhibiting Dickkopf-1. Cancer Res. 2013; 73: 6526-37. （Nature Index 期刊, 影响因子12.701）

  16. Cheng L, Guo H, Qiao X, Liu Q, Nie J, Li J, Wang J, Jiang K. T cell immunohistochemistry refines lung transplant acute rejection diagnosis and grading. Diagn Pathol. 2013;8:168.

  17. Turnquist HR, Zhao Z, Rosborough BR, Liu Q, Castellaneta A, Isse K, Wang Z, Lang M, Stolz DB, Zheng XX, Demetris AJ, Liew FY, Wood KJ, Thomson AW. IL-33 expands suppressive CD11b+ Gr-1int and regulatory T cells, including ST2L+ Foxp3+ cells, and mediates regulatory T cell-dependent promotion of cardiac allograft survival. J Immunol. 2011; 187: 4598-610.

  18. Divito SJ, Wang Z, Shufesky WJ, Liu Q, Tkacheva OA, Montecalvo A, Erdos G, Larregina AT, Morelli AE. Endogenous dendritic cells mediate the effects of intravenously injected therapeutic immunosuppressive dendritic cells in transplantation. Blood. 2010; 116: 2694-705. (影响因子22.113)


    Literature review

  19. Liu Q, Turnquist HR. Controlling the burn and fueling the fire: defining the role for the alarmin interleukin-33 in alloimmunity. Curr Opin Organ Transplant. 2016;21:45-52.

  20. Liu Q, Turnquist HR. Implications for Interleukin-33 in solid organ   transplantation. Cytokine. 2013;62:183-94.