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南科大医学院
官方公众号

张志荣
助理教授
zhangzr@sustech.edu.cn 
个人简介

张志荣博士,博士生导师,副研究员,南方科技大学医学院生物化学系助理教授。2013年于厦门大学获得博士学位;随后加入法国遗传与分子细胞生物学研究所 (IGBMC) 进行博士后研究工作;2023年12月加入南方科技大学医学院,建立独立课题组。长期聚焦于人体免疫激活机制及新型免疫治疗技术开发,取得一系列原创性成果,以第一作者或兼通讯作者(含共同)发表于Nature Immunology、Science Immunology、Journal of Experimental Medicine、American Journal of Transplantation和Journal of Immunology上;同时以合作作者在Science、Nature Cell Biology、Nature Metabolism、Nature Communications和Cell Reports等期刊上发表;总引用次数超过3000次(谷歌学术).


研究领域

1) 人体免疫激活机制;

2) 病原体与宿主相互作用及感染性疾病的发病机理;

3) 新型免疫治疗技术开发。


教育背景

09/2007 - 07/2013, 动物学,博士, 厦门大学

09/2003 - 07/2007, 生物技术(基地班),学士, 内蒙古大学 



工作经历

12/2023至今,助理教授,南方科技大学医学院

09/2013 - 11/2023, 博士后, 法国遗传与分子细胞生物学研究所(IGBMC)

获奖情况及荣誉

· 深圳市医学研究专项一般项目,2026

· 国家自然科学基金面上项目,2025

· 深圳市自然科学基金面上项目,2025

· USIAS博士后奖学金, 2017

· EMBO meeting旅行津贴(travel grant), 德国曼海姆, 2016

· EFSD/CDS/Lilly项目, 2013



杂志编委会委员

Frontiers in Cell Death审稿编辑

Frontiers in Immunology审稿编辑

Frontiers in Immunology客座编辑


近年代表文章

[27] Li X*, Zhang Z*, Zhang Y, Zhang L, Huang A, Chen W, Zhang W, Li C, Wei H, Zheng C, Liu J, Liu Q. Transmembrane protein 16F-chloride intracellular channel 1 interaction mediates recipient dendritic cell cross-decoration after transplantation. American Journal of Transplantation. 2025 Dec 24:S1600-6135(25)03190-9. (*共同第一作者).

[26] Jia T, Li F, Li T, Ren A, Lu P, Liu Y, Zhou Y, Duan X, Liu Y, Zhong L, Zhang Z, Tan CSH, Yang L. A Pseudomonas aeruginosa quorum-sensing metabolite manipulates macrophage ferroptosis through a methylation pathway. Nature Communications 2025;16(1):9992.

[25] Dai K, An J, Wang C, Huang J, Yang H, Shuai S, Yan R, Zhang Z, Zheng Z, Qin G, Han C. Advancements in bioorthogonal chemistry and click reactions for labeling and tracking extracellular vesicles in tissue homeostasis research. Oral Science and Homeostatic Medicine 2025, 1:9610007

[24] Ran L*, Ye T, Erbs E, Ehl S, Spassky N, Sumara I, Zhang Z*#, Ricci R#. KCNN4 links PIEZO-dependent mechanotransduction to NLRP3 inflammasome. Science Immunology 2023 Dec 22;8(90):eadf4699. (#共同通讯作者; *共同第一作者).

[23] Zhang Z#*, Venditti R*, Ran L, Liu Z, Vivot K, Schurmann A, Bonifacino J, de Matteis A#, Ricci R#. Distinct changes in endosomal composition promote NLRP3 inflammasome activation. Nature Immunology 2023; 24(1):30-41. (#共同通讯作者; *共同第一作者).

[22] Zhang Z#, Ricci R#. Hijacking the NLRP3 inflammasome: a mechanism underlying viral respiratory disease? EMBO Reports 2020; 21(7): e50645. (#共同通讯作者).

[21] Zhang Z, Meszaros G, He W, Xu Y, de Fatima Magliarelli H, Mailly L, Mihlan M, Liu Y, Gámez M, Goginashvili A, Pasquier A, Bielska O, Neven B, Quartier A, Aebersold R, Baument TF, Georgel P, Han J, Ricci R. Protein kinase D at the Golgi controls NLRP3 inflammasome activation. Journal of Experimental Medicine 2017; 214 (9): 2671-2693.

[20] Zhang Z, Xu X, Ma J, Wu J, Wang Y, Zhou R, Han, J. Gene deletion of Gabarap enhances Nlrp3 inflammasome-dependent inflammatory responses. Journal of Immunology 2013; 190(7):3517-24.

[19] Goginashvili A, Zhang Z, Erbs E, Spiegelhalter C, Kessler P, Mihlan M, Pasquier A, Krupina K, Schieber N, Cinque L, Morvan J, Sumara I, Schwab Y, Settembre C, Ricci R. Insulin secretory granules control autophagy in pancreatic β cells. Science 2015; 347:878–882.

[18] Vivot K, Pangou E, Meszaros G, Zhang Z, Erbs E, Yeghiazaryan G, Quiñones M, Grandgirard E, Schneider A, Clauss-Creusot E, Charlet A, Faour M, Martin C, Luquet E, Kloppenburg P, Nogueiras R, Ricci R. CaMK1D signaling in AgRP neurons promotes ghrelin-mediated food intake. Nature Metabolism 2023, 5(6): 1045-1058.

[17] Liao Y, Andronov L, Liu X, Lin J, Guerber L, Lu L, Agote-Arán A, Pangou E, Ran L, Kleiss C, Qu M, Schmucker S, Cirillo L, Zhang Z, Riveline D, Gotta M, Klaholz BP, Sumara I. UBAP2L ensures homeostasis of nuclear pore complexes at the intact nuclear envelope. Journal of Cell Biology 2024; 223(7):e202310006

[16] Niu T, De Rosny C, Chautard S, Rey A, Patoli D, Groslambert M, Cosson C, Lagrange B, Zhang Z, Visvikis O, Hacot S, Hologne M, Walker O, Wong J, Wang P, Ricci R, Henry T, Boyer L, Petrilli V, Py B. NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly. Nature Communications 2021; 12(1):5862

[15] Pangou E*, Bielska O*, Guerber L, Schmucker S, Agote-Aran Arantxa, Ye T, Liao Y, Puig-Gamez M, Grandgirard E, Kleiss C, Liu Y, Compe E, Zhang Z, Aebersold R, Ricci R#, Sumara I#. A PKD-MFF signaling axis couples mitochondrial fission to mitotic progression. Cell Reports 2021; 35(7):109129. (#corresponding authors; *equal contribution)

[14] Pasquier A, Vivot K, Erbs E, Spiegelhalter C, Zhang Z, Aubert V, Liu Z, Senkara M, Maillard E, Pinget M, Kerr-Conte J, Pattou F, Marciniak G, Ganzhorn A, Ronchi P, Schieber N, Schwab Y, Saftig P, Goginashvili A#, Ricci R#. Lysosomal degradation of newly formed insulin granules contributes to β cell failure in diabetes. Nature Communications 2019;10(1):3312. (#corresponding authors)

[13] Ma H, Liu Z, Zhong C, Liu Y, Zhang Z, Liang Y, Li J, Han S, Han J. Inactivation of cyclic AMP response element transcription caused by constitutive p38 activation is mediated by hyperphosphorylation-dependent CRTC2 nucleocytoplasmic transport. Molecular and Cellular Biology 2019; 39(9): e00554-18.

[12] Xu Y, Ma H, Fang L, Zhang Z, Shao J, Hong M, Huang C, Liu J, Chen R. Cisplatin-induced necroptosis in TNFα dependent and independent pathways. Cellular Signaling 2017; 31:112-123.

[11] de Fatima Magliarelli H, Matondo M, Mészáros G, Goginashvili A, Erbs E, Zhang Z, Mihlan M, Wolfrum C, Aebersold R, Sumara I, Ricci R. Liver ubiquitome uncovers nutrient-stress-mediated trafficking and secretion of complement C3. Cell Death & Diseases 2016; 7(10):e2411.

[10] Chen W, Wu J, Li L, Zhang Z, Ren J, Liang Y, Chen F, Yang C, Zhou Z, Su S, Zheng X, Zhang Z, Zhong C, Wan H, Xiao M, Lin X, Feng X, Han J. Ppm1b negatively regulates necroptosis through dephosphorylating Rip3. Nature Cell Biology 2015 17, 434–444.

[9] Xu Y, Ma H, Shao J, Wu J, Zhou L, Zhang Z, Wang Y, Huang Z, Ren J, Liu S, Chen X, Han J. A Role for Tubular Necroptosis in Cisplatin-Induced AKI. Journal of American Society of Nephrology 2015; 26:2647–2658.

[8] Xu X, Leng J, Gao F, Zhao Z, Deng W, Liang X, Zhang Y, Zhang Z, Li M, Sha A, Yang Z. Differential expression and anti-oxidant function of glutathione peroxidase 3 in mouse uterus during decidualization. FEBS Letters 2014 ; 588: 1580–1589.

[7] Wu J, Huang Z, Ren J, Zhang Z, He P, Li Y, Ma J, Chen W, Zhang Y, Zhou X, Yang Z, Wu S, Chen L, Han J. Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis. Cell Research 2013; 23:994–1006.

[6] Lin J*, Li H*, Yang M, Ren J, Huang Z, Han F, Huang J, Ma J, Zhang D, Zhang Z, Wu J, Huang D, Qiao M, Jin G, Wu Q, Huang Y, Du J, Han J. A Role of RIP3-Mediated Macrophage Necrosis in Atherosclerosis Development. Cell Reports 2013; 3:200-210. (*equal contribution)

[5] Zhang X, Liang X, Wang T, Liang X, Zuo R, Deng W, Zhang Z, Qin F, Zhao Z, Yang Z. Heparin-binding epidermal growth factor-like growth factor (HB-EGF) induction on Snail expression during mouse decidualization. Molecular and Cellular Endocrinology 2013; 381:272–279

[4] Lei W, Feng X, Deng W, Ni H, Zhang Z, Jia B, Yang X, Wang T, Liu J, Su R, Liang X, Qi, Q, Yang Z. Progesterone and DNA damage encourage uterine cell proliferation and decidualization through up-regulating ribonucleotide reductase 2 expression during early pregnancy in mice. Journal of Biological Chemistry 2012; 287:15174-15192.

[3] Zhao Z, Zhang Z, Xu X, Deng W, Li M, Leng J, Liang X, Yang Z. Arachidonic acid regulation of the cytosolic phospholipase A 2alpha/cyclooxygenase-2 pathway in mouse endometrial stromal cells. Fertility & Sterility 2012; 97 :1199-1205 e1191-1199.

[2] Tian Z, Zhao Z, Liang X, Zhang X, Sha A, Zhang Z, Yu Y, Yang, Z. Expression and function of fatty acid-binding protein 4 during mouse decidualization. Fertility & Sterility 2011; 95:2749-2752 e2741-2745.

[1] Su R, Lei W, Liu J, Zhang Z, Jia B, Feng X, Ren G, Hu S, Yang Z. The integrative analysis of microRNA and mRNA expression in mouse uterus under delayed implantation and activation. PLoS One 2010; 5:e15513.

专利情况

鲁昊骋; 王赞鑫; 张志荣。钾钙激活通道亚家族N成员4抑制剂在制备防治腹主动脉瘤和/或延缓腹主动脉瘤病程进展的药物中的应用。ZL202510637667.0。2025.07.25。