颜正伟，南方科技大学医学院研究助理教授。研究领域为细胞中营养物质（如氨基酸）的感知机制及蛋白降解在肿瘤中作用机制。目前发表学术论文8篇，相关研究成果以第一作者（含共同第一）发表于Oncogene（2025）、Cell Death & Disease（2021）、The Journal of Biological Chemistry（2020）、Journal of Experimental & Clinical Cancer Research（2019）、Brain and Behavior（2019）、BBRC（2016）等期刊。主持国家自然科学基金青年项目1项、中国博士后科学基金面上项目1项、江西省自然科学基金青年项目1项、江西省教育厅重点基金1项。
细胞中营养物质（如氨基酸）的感知机制；蛋白降解在肿瘤进展中作用机制。
2016.9至2019.6 南昌大学 临床病理与病理生理学 博士
2018.3至2019.3 美国德克萨斯大学健康科学中心 联合培养
2013.9至2016.6 南昌大学 生物学 硕士
2009.9至2013.7 南昌大学 生物技术 学士
2024.8至今 南方科技大学医学院 研究助理教授
2022.4至2024.7 南方科技大学医学院 博士后， 导师：饶海
2019.7至2022.2 南昌大学第一附属医院 助理研究员
1. Zhengwei Yan#, Luling He#, Jiawei Yuan, Yulong Niu, Shimin Shuai, Shiwen Luo, Changzheng Du, Hai Rao*. The splicing factor SRRM2 modulates two S6K kinases to promote colorectal cancer growth. Oncogene, 2025 (Accepted).
2. Zhengwei Yan#, Minzhang Cheng#, Guohui Hu#, Yao Wang, Shaopeng Zeng, Aidi Huang, Linlin Xu, Yuan Liu, Chao Shi, Libin Deng, Quqin Lu, Hai Rao, Hua Lu, Ye-Guang Chen*, Shiwen Luo*. Positive feedback of SuFu negating protein 1 on Hedgehog signaling promotes colorectal tumor growth. Cell Death & Disease, 2021, 12(2): 0-199.
3. Zhengwei Yan#, Karthigayan Shanmugasundaram, Dongwen Ma, Jiayu Luo, Shiwen Luo*, Hai Rao*. The N-terminal domain of the non-receptor tyrosine kinase ABL confers protein instability and suppresses tumorigenesis. The Journal of Biological Chemistry, 2020, 295(27): 9069-9075.
4. Guohui Hu#, Zhengwei Yan#, Cheng Zhang, Minzhang Cheng, Yehong Yan, Yiting Wang, Libin Deng, Quqin Lu, Shiwen Luo*. FoxM1 promotes hepatocellular carcinoma progression by regulating KIF4A expression. Journal of Experimental & Clinical Cancer Research, 2019, 38(1): 188.
5. Lingchen Wang#, Zhengwei Yan#, Xiaona He, Cheng Zhang, Huiqiang Yu, Quqin Lu*. A 5-gene prognostic nomogram predicting survival probability of glioblastoma patients. Brain and Behavior, 2019, e01258.
6. Zhengwei Yan#, Liyao Xu#, Junyan Zhang, Quqin Lu, Shiwen Luo, Linlin Xu*. Aldehyde dehydrogenase 1A1 stabilizes transcription factor Gli2 and enhances the activity of Hedgehog signaling in hepatocellular cancer. Biochemical and Biophysical Research Communications, 2016, 471(4): 466-73.
7. Guohui Hu, Lizette Rios, Zhengwei Yan, Angela M Jasper, Dezzarae Luera, Shiwen Luo, Hai Rao*. Autophagy regulator Atg9 is degraded by the proteasome. Biochemical and Biophysical Research Communications 2020 522(1: 254-258.)
8. Yiting Wang, Hailong Wang, Zhengwei Yan, Guohua Li, Guohui Hu, Hong Zhang, Dengliang Huang, Yao Wang, Xiang Zhang, Yehong Yan, Quqin Lu, Minzhang Cheng, Shiwen Luo*. The critical role of dysregulated Hh-FOXM1-TPX2 signaling in human hepatocellular carcinoma cell proliferation. Cell communication and signaling, 2020, CCS 18: 116