南方科技大学伦敦国王学院医学院副院长，南科大医学院教授，博士生导师，致诚书院院长，“百千万人才工程”国家级人选，国务院特贴专家，深圳市引进国家级领军人才（A类）。2011年创建华南地区首家转化医学研究中心并任主任。曾创建和担任“长寿与老年相关疾病”教育部重点实验室主任。目前担任广东省细胞微环境与疾病研究重点实验室学术委员会委员；中国抗癌协会肿瘤转移专业委员会常委和青委会主任委员；中国生物技术学会转化医学分会副主任委员；广东省转化医学学会顾问委员会主任；深圳市生物医药促进会副会长；中国肿瘤防治联盟深圳市联盟副主席；2015-2017《Medical Oncology》副主编。SCI 发表文章总数130余篇。 博士毕业于美国密歇根大学医学院，2004 年起任美国国防部（DOD）医学课题评审委员，从2009 年起任我国教育部长江学者和自然科学基金杰青、国合、重点、海外优青、面上等项目评审专家。2013 年被选为“全国优秀科技工作者”，2014 年入选“国家百千万人才工程”和“国家有突出贡献中青年专家”。2016年获批深圳市引进国家级领军人才（A类），负责筹备和成功申报并获批南方科技大学医学院临床医学和生物医学科学本科专业。
肿瘤转化医学研究
肿瘤耐药、复发与转移
衰老与肿瘤
1981-1986: 学士，天津医科大学临床医学系
1997-1998: 硕士，Old Dominion University & East Virginia Medical School 免疫学专业
1998-2001: 博士， University of Michigan 病理学专业
1986.8-1995.1 天津市第三医院/天津市老年医学研究所，内科住院医师、主治医师
1995.1-1996.8 美国威斯康星-麦迪逊大学老年医学研究所 世界卫生组织奖学金访问学者
1996.8-1998.8 东弗吉尼亚医学院老年医学研究中心Visiting Research Scientist
1998.8-2004.6 美国密歇根大学医学院博士在学/研究员
2004.7-2010.12 美国匹兹堡大学和密歇根大学医学院助理教授 (Tenure track)
2011.1-2016. 7 长寿与老年相关疾病省部共建教育部重点实验室/广西医科大学转化医学院就中心主任/教授
2016.07-2019.07 南方科技大学医学院筹建办执行主任/教授
2020.10-至今 南方科技大学医学院教授, 致诚书院院长
2022. 03-至今 南方科技大学伦敦国王学院医学院副院长
2019-深圳市生物医药促进会副会长
2018-中国肿瘤防治联盟深圳市联盟副主席
2014-获得国务院政府特殊津贴专家
2013-入选国家百千万人才工程国家级人选并获“有突出贡献的中青年专家”荣誉称号
2013-美国基础泌尿研究学会(SBUR)颁发的International lecturer证书
2012-全国优秀科技工作者
2011-广西壮族自治区八桂学者、广西壮族自治区政府参事
2007-Mentoring Dr. Yi Lu, Young Investigator Travel Award, ASBMR
2005-Mentoring Dr. Yi Lu, Scholar-in-Training Award, AACR
2003-Scholar-in-Training Award, AACR
2003- Plenary Poster Award of 25th Annual Meeting of American Society for Bone and Mineral Research
2002-Alice L. Jee Memorial Young Investigator Award
2000-Plenary Poster Award of 22nd Annual Meeting of American Society for Bone and Mineral Research
1994- Fellowship Award, World Health Organization (WHO)
Journals Ad hoc reviewer（受邀审稿人）
Journal of Gerontology; Biological Sciences; Bone; Cancer Research; The Prostate; Journal of Clinical Investigation; Clinical Cancer Research; Neoplasia; Molecular Cancer Research; Journal Bone Mineral Research; International Journal of Cancer; British Journal of Cancer; Molecular Cancer Therapeutics; Peptides; Journal of Cellular and Molecular Medicine; Cancer Immunology Therapeutics; Cancer Metastasis Reviews; Carcinogenesis; Oncotarget
Associate Editor (副主编)
Medical Oncology; Chinese Journal of Cancer
Editorial board member （编委）
The Open Prostate Cancer Journal; Chinese Journal of Lung Cancer; Thoracic Cancer
近六年发表的SCI论文
1. Wang W, Yang X, Dai J, Lu Y, Zhang J, and Keller E*. Prostate cancer promotes a vicious cycle of bone metastasis progression through inducing osteocytes to secrete GDF15 that stimulates prostate cancer growth and invasion. Oncogene, 2019, 38(23):4540-45559
2. Su W, Wang L, Niu F, Zou L, Guo C, Wang Z, Yang X, Wu J, Lu Y, Zhang J, Beer DG, Yang Z, Chen G. LINC00857 knockdown inhibits cell proliferation and induces apoptosis via involving STAT3 and MET oncogenic proteins in esophageal adenocarcinoma. Aging-US. 2019, 11(9):2812-2821
3. Guo H, Wang F, Diao Y, Zhang Z, Chen Q, Qian CN, Keller ET, Zhang J*, Lu Y*. Knockdown of Notch1 inhibits nasopharyngeal carcinoma cell growth and metastasis via downregulation of CCL2, CXCL16, and uPA. Molecular Carcinogenesis, 2019, 58:1886-1896
4. Yun C, Chang M, Hou G, Lan T, Yuan H, Su Z, Zhu D, Liang W, Li Q, Zhu H, Zhang J, Lu Y*, Deng J*, Guo H*. Mangiferin suppresses allergic asthma symptoms by decreased Th9 and Th17 responses and increased Treg response. Molecular Immunology. 2019, 114:233-242
5. Song Q, Qin S, Pascal L, Zou C, Wang W, Tong H, Zhang J, Catalona W, Dhir R, Morrell M, Balasubramani G, Lu Y*, Wang Z*. SIRPB1 promotes prostate cancer cell proliferation via Akt activation. The Prostate, March 2020, 80 (4): 352-364
6. Wei T, Wang H, Wu X, Lu Y, Guan S, Dong F, Dong C, Zhu G, Bao Y, Zhang J*, Wang G*, and Li H*. In Silico Screening of Potential Spike Glycoprotein Inhibitors of SARS-CoV-2 with Drug Repurposing Strategy. Chin J Integr Med. 2020, 26(9):663-669
7. Qin S, Jiang J, Tang B, Lu Y, Nice EC, Huang C*, Zhang J*, He W*. Emerging Role of Tumor Cell Plasticity in Modifying Therapeutic Response. Signal Transduction and Targeted Therapy, 2020, 5(1):228
8. Yu W, Zhang X, Zhang W, Xiong M, Lin Y, Chang M, Xu L, Lu Y*, Liu Y*, Zhang J*. 19-Hydroxybufalin inhibits non-small cell lung cancer cell proliferation and promotes cell apoptosis via the Wnt/β-catenin pathway. Exp Hematol Oncol. 2021, 10(1):48
9. Lu Y, Di YP*, Chang M, Huang X, Chen Q, Hong N, Kahkonen BA, Di ME, Yu C, Keller ET, Zhang J*. Cigarette smoke-associated inflammation impairs bone remodeling through NFκB activation. J Transl Med. 2021, 19(1):163
10. Chang M, Zhu D, Chen Y, Zhang W, Liu X, Li XL, Cheng Z, Su Z, Zhang J*, Lu Y*, Guo H*. Total flavonoids of Litchi Seed attenuate prostate cancer progression via inhibiting AKT/mtor and NF-kb signaling pathways. Front Pharmacol. 2021,12:758219
11. Wei T, Lin R, Fu X, Lu Y, Zhang W, Li Z, Zhang J*, and Wang H*. Epigenetic regulation of the DNMT/MT1G/KLF4/CA9 axis synergizes the anticancer effects of sorafenib in hepatocellular carcinoma. Pharmacological Research. 2022, 180:106244.
12. Chen E, Yi J, Jiang J, Zou Z, Mo Y, Ren Q, Lin Z, Lu Y, Zhang J* and Liu J*. Identification and validation of a fatty acid metabolism-related lncRNA signature as a predictor for prognosis and immunotherapy in patients with liver cancer. BMC Cancer. 2022, 22:1037
13. Zhang Z, Qin S, Chen Y, Zhou L, Yang M, Tang Y, Zuo J, Zhang J, Mizokami A, Nice E, Chen H, Huang C, Wei X. Inhibition of NPC1L1 disrupts adaptive responses of drug-tolerant persister cells to chemotherapy. EMBO Molecular Medicine, 2022, 14(2):e14903.
14. Zhang X, Wei T, Wu C, Jiang J, Chen S, Hu Y, Lu Y, Sun D, Zhai L, Zhang J*, Liu C. Cryo-EM structure reveals polymorphic ligand-bound states of IGF1R. Journal of Molecular Biology. 2022, 2022 May 15;434(9):167536. doi: 10.1016/j.jmb.2022.167536. Epub 2022 Mar 15
15. Zhang X, Wu C, Wei T, Lu Y*, Liu C*, Zhang J*. Cryo-EM studies of the apo states of human IGF1R. BBRC. 2022, 618: 148-152.
16. Chang M, He Y, Liu C, Lin R, Huang X, Liang D, Zhang J*, Lu Y*. Downregulation of SEPTIN5 inhibits prostate cancer progression by increasing CD8+T cell infiltration. International Journal of Biological Science. 2022, 18 (16):6035-51.
17. Chen E, He Y, Jiang J, Yi J, Zou Z, Song Q, Ren Q, Lin Z, Lu Y*, Liu J*, and Zhang J*. CDCA8 induced by NF-YA promotes hepatocellular carcinoma progression by regulating the MEK/ERK pathway. Experimental Hematology & Oncology. 2023, 12:9.
18. Qin S, Zhang Z, Huang Z, Luo Y, Weng N, Li B, Tang Y, Zhou L, Jiang J, Lu Y, Shao J, Xie N, Nice EC, Chen Z, Zhang J*, Huang C*. CCT251545 enhances drug delivery and potentiates chemotherapy in multidrug-resistant cancers by Rac1 mediated micropinocytosis. Drug Resistance Updates. 2023, 66:100906.
19. Ye X, Liu J, Quan R, Lu Y*, Zhang J*. DKK1 affects survival of patients with head and neck squamous cell carcinoma by inducing resistance to radiotherapy and immunotherapy. Radiotherapy and Oncology. 2023, 181:109485.
20. Qiao T, Yang W, He X, Song P, Chen X, Liu R, Xiao J, Yang X, Li M, Gao Y, Chen G, Lu Y, Zhang J*, Leng J*, and Ren H*. Dynamic differentiation of F4/80+ tumor-associated macrophage and its role in tumor vascularization in a syngeneic mouse model of colorectal liver metastasis. Cell Death & Diseases. 2023, 14:117.
21. Ye X, Huang X, Fu X, Zhang X, Lin R, Zhang W, Zhang J*, Lu Y *. Myeloid-like Tumor Hybrid Cells in Bone Marrow Promote Promote Progression of Prostate Cancer Bone Metastasis. Journal of Hematology & Oncology. 2023, 16:46.
22. Chen X, Hao Y, Liu Y, Zhong S, You Y, Ao K, Chong T, Luo X, Yin M, Ye M, He H, Lu A, Chen J, Li X*, Zhang J*, and Guo X*. NAT10/ac4C/FOXP1 promotes malignant progression and facilitates immunosuppression by reprogramming glycolytic metabolism in cervical cancer. Advanced Science, 2023, 2302705.
23. Wu J, Huang X, Li X, Zhou H, Chen X, Chen Y, Guo Y, Huang J, Huang H, Huang Z, Chen G, Yang Z*, Zhang J*, and Su W*. Suppression of the long non coding RNA LINC01279 triggers autophagy and apoptosis in lung cancer by regulating FAK and SIN3A. Discover Oncology, 2024, 15:3.
24. Wang F, Fu X, Chang M, Wei T, Lin R, Tong H, Zhang X, Yuan R, Zhou Z, Huang X， Zhang W, Su W, Lu Y*, Liang Z*, and Zhang J*. The interaction of calcium-sensing receptor with KIF11 enhances cisplatin resistance in lung adenocarcinoma via BRCA1/cyclin B1 pathway. International Journal of Biological Science. 2024, 20 (10):3892-3910.
25. Wei T, Lin R, Lu Y, Jin DY*, Zhang J*, Sham MH*. Protein phosphatase EYA1 regulates the dephosphorylating and turnover of BCL2L12 to promote glioma development. International Journal of Biological Science. 2025, In press.
目前在修稿或评审中的文章
1. Zhang Y, Xu Z, Ye X, Lian J, Ye B, Li H, Zheng D, Jiang Y, Zhao C, Liu Y, Lin Z, Zang D, Wang E, Cai M, Xie Z, Zhou P, Guan X, Hong X, Lu Y, Zhang Y*, Zhang J*, Zheng H*, Kong FM*, Yu H*. Revealing the cold TIME with a novel tumor-macrophage fusion cell subtype in HPV-cervical cancer by integrating scRNA-seq and spatial transcriptomics. Science Immunology. 2025, under review.
2. Zhang X, Yu W, Sun Y, Ye X, He Y, Huang X, Wang F, Lu Y*, Zhang J*. Anti-inflammatory resveratrol protects mice from early mortality after hematopoietic stem cell transplantation. Journal of Cellular and Molecular Medicine. 2024 in Revision
3. Ye B, Wang Z, Bai Y, Zhang X, Zhang R, Lian J, Liu X, Zhang Y, Xu Z, Yang L, Jin H, Chen F, Xie Z, Zhou P, Tan J, Zeng S, Du C, Yang M, Li H, Duan J, Li Z, Yang H, Cai Y, Wu H, Liu CC, Cai J, Lu Y, Zhang J, Wu H, Hong X*, Zheng H*, Liu L*, Yu H*. In Situ Detection of Circulating Tumor Cells. Nature Cancer, 2024 submitted
4. Zhang W, Qin S, Li X, Lu S, Chang M, Wei T, Huang X, Tong H, Lu X*, Guo X*, Lu Y*, Zhang J*. SMC4 promotes prostate cancer cell proliferation and metastasis via Rheb/mTOR pathway. Advanced Science, 2024 in Revision