南方科技大学讲席教授、医学院副院长，乌克兰工程院外籍院士，国际华人骨研学会现任主席，广东省细胞微环境与疾病研究重点实验室主任, 美国骨矿研究学会(ASBMR)会士, 连续荣登爱思唯尔中国高被引学者 （生物学)和全球前2%顶尖科学家榜单。研究骨骼发育和骨骼疾病 （骨质疏松、骨关节炎等）的相关分子基础。北京大学医学部博士；美国密歇根大学博士后；美国匹茨堡大学医学院助理教授、副教授；美国拉什大学教授、冠名讲席教授、生物化学系的研究主任；历任南方科技大学生物系系主任、致诚书院院长。主持国自然重大、重点等项目。发表SCI文章185篇, 引用19000余次，总影响因子约1875, H指数70。实验室成果在国际骨科研究大会获奖10余次。担任JOT副主编, 担任JBMR及 JBC等国际学术刊物编委，担任70个国际杂志的审稿人。北京大学医学部（原北京医科大学）100周年校庆，优秀校友。
（1）研究调节骨骼发育及稳态的分子机制；
（2）研究骨质疏松症，骨性关节炎及脊柱退行性变等骨骼疾病的分子基础；
（3）研究骨机械应力信号传导机制；
（4）代谢性疾病的发病机制研究。
1991-1994：北京大学医学部生物化学和分子生物学系，博士学位
1985-1988：北京大学医学部生物化学和分子生物学系，硕士学位
1979-1984：南昌大学医学院医疗系，医疗专业，医学学士学位
2020- 南方科技大学教授, 医学院副院长
2019-2020 南方科技大学致诚书院院长
2017- 南方科技大学实验动物中心主任
2015-2018 南方科技大学生物系系主任
2013-2019 南方科技大学生物系教授
2012-2017 美国拉什大学医学中心副教授，正教授、讲席教授(Falk Chair Professor)、生物化学系科研主任
2005-2011 美国匹兹堡大学医学院助理教授、终身副教授
1994-2005 美国密歇根大学医学院/牙学院博士后、讲师、研究助理教授
1988-1991 北京大学医学部， 讲师
2023 国际华人骨研学会主席 (International Chinese Musculoskeletal Research Society (ICMRS), president); https://icmrs.net/leadership
2022 南方科技大学优秀研究生导师奖
2022 乌克兰工程院外籍院士
2021, 2022, 2023, 2024 全球前2%顶尖科学家 (World’s Top 2% Scientists by Stanford University)
2021, 2022, 2023 爱思唯尔 (Elsevier)中国高被引学者 （生物学）(Most Cited Chinese Researchers, Biology)
2020 南方科技大学年度教授奖
2019 国际骨科研究联合学会 (ICORS)，会士
2019 美国骨与矿研究学会 (ASBMR), 会士
2012 北京大学医学部(原北京医科大学) 100周年校庆，优秀校友
2023- Journal of Orthopaedic Translation (JOT), associate editor
2009-2015 Journal of Bone and Mineral Research (JBMR), editorial board member
2013-2022 Journal of Biological Chemistry (JBC), editorial board member
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2. Walke W, Xiao G, and Goldman D. Identification and characterization of a 47 base pair activity-dependent enhancer of the rat nicotinic acetylcholine receptor d-subunit promoter. J Neurosci. 1996; 16(11): 3641-3651.
3. Xiao G, Cui Y, Ducy P, Karsenty G, and Franceschi RT. Ascorbic acid-dependent activation of the osteocalcin promoter in MC3T3-E1 preosteoblasts: requirement for collagen matrix synthesis and the presence of an intact OSE2 sequence. Mol Endocrinol. 1997; 11:1103-1113.
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8. Xiao G, Jiang D, Thomas PE, Benson MD, Guan KL, Karsenty G, and Franceschi RT. MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Osf2/Cbfa1. J Biol Chem. 2000; 275, 4453-4459.
9. Benson MD, Bargeon JL, Xiao G, Thomas PE, Ahn Kim, Yingqi Cui, and Franceschi RT. Identification of a homeodomain binding element in the bone sialoprotein gene promoter which is required for its osteoblast-selective expression. J Biol Chem. 2000; 275: 13907-13917.
10. Franceschi RT. Xiao G, Thomas PE, Jiang D, and Benson MD. Extracellular matrix regulation of osteoblast-specific gene expression: role of the a2b1 integrin and Osf2/Cbfa1. Chemistry and Biology of Mineralized Tissues: Connect Tissue Res. 2000;41 Suppl 1:249-254.
11. Ma PX, Zhang R, Xiao G, and Franceschi RT. Engineering new bone tissue in vitro on highly pore poly(-hydroxyl acids)/hydroxyapatite composite scaffolds. J Biomed Mater Res. 2001; 54:284-293.
12. Xiao G, Jiang D, Gopalakrishnan R, and Franceschi RT. FGF-2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2. J Biol Chem. 2002; 277:36181-36187.
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14. Xiao G, Gopalakrishnan R, Jiang D, Reith E, Benson MD, and Franceschi RT. BMP, extracellular matrix, and MAP kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells. J Bone Miner Res. 2002; 17:101-110.
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16. Franceschi RT. Xiao G, Jiang D, Gopalakrishnan R, Yang S and Reith E. Multiple signaling pathways converge on the Cbfa1/Runx2 transcription factor to regulate osteoblast differentiation: Connect Tissue Res. 2003;44 Suppl 1:109-16.
17. Chen C, Koh AJ, Datta NS, Zhang J, Even ET, Xiao G, Franceschi RT, D'Silva NJ, and McCauley LK. Impact of mitogen-activated protein kinase (MAPK) pathway on parathyroid hormone related protein actions in osteoblasts. J Biol Chem. 2004; 279, 29121-29129.
18. Jiang D, Franceschi RT, Boules H, and Xiao G*. Parathyroid Hormone Induction of the Osteocalcin Gene:requirement for an osteoblast-specific element 1 sequence in the promoter and involvement of multiple signaling pathways. J Biol Chem. 2004; 279:5329-5337.
19. Xiao G*, Jiang D, Ge C, Zhao Z, Yumei Lai, Boules H, Phimphilai M, Yang X, Karsenty G, and Boules H, and Franceschi RT. Cooperative interactions between activating transcription factor 4 and Runx2/Cbfa1 stimulate osteoblast-specific osteocalcin gene expression. J Biol Chem. 2005; 280:30689-30696.
20. Roca H, Phimphilai M, Gopalakrishnan R, Xiao G, and Franceschi RT. Cooprative interactions between RUNX2 and homeodomain protein binding sites are critical for the osteoblast-specific expression of the bone sialoprotein gene. J Biol Chem. 2005; 280:30845-30855.
21. Zhao Z, Zhao M, Xiao G, and Franceschi RT. Gene transfer of the Runx2 transcription factor enhances osteogenic activity of bone marrow stromal cells in vitro and in vivo. Mol Ther. 2005; 12(2):247-53.
22. Lu, Y, Cai Z, Galson DL, Xiao G, Liu, Y, George DE, Melhem MF, Yao Z, Zhang J. Monocyte chemotactic protein-1 (MCP-1) acts as a paracrine and autocrine factor for prostate cancer growth and invasion. Prostate. 2006; 66(12): 1311-8.
23. Franceschi RT, Xiao G. Osteoblasts: Staying the course. Meeting report from the 29th Annual Meeting of the American Society for Bone and Mineral Research. BoneKEy-Osteovision 2006; 4 (12), 327-332.
24. Zhu J, Jia X, Xiao G, Kang Y, Partridge, NC, Qin L. EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors in osteoblasts: implications in osteolytic bone metastases. J Biol Chem.2007; 282(37): 26656-64.
25. Franceschi RT, Ge C, Xiao G, Roca H, Jiang D. Transcriptional regulation of osteoblasts. Ann N Y Acad Sci. 2007; 1116:196-207.
26. Lu Y, Xiao G, Galson DL, Nishio Y, Mizokami A, Keller E, Yao Z, and Zhang J. PTHrP-induced production of monocyte chemoattractant protein-1 (MCP-1) by human bone marrow endothelial cells and osteoblasts promotes osteoclast differentiation in vitro: a novel role in prostate cancer bone metastasis. Int J Cancer. 2007; 121(4): 724-733.
27. Lu Y, Cai Z, Xiao G, Liu Y, Keller E, Yao Z, and Zhang J. CCR2 expression correlates with prostate cancer progression. J Cell Biochem. 2007; 101(3): 676-85.
28. Lu Y, Cai Z, Xiao G, Yao Z, Anderson JL, Roodman DG, and Zhang J. Prostate cancer cells induce osteoclastogenesis and bone resorption through RANKL-independent interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) production. Cancer Res. 2007; 67(8): 3646-53.
29. Ge C, Xiao G, Jiang D, and Franceschi RT. Critical role of extracellular signal-regulated kinase/MAPK pathway in osteoblast differentiation and skeletal development. J Cell Biol. 2007; 176(5): 709-818. PMCID: PMC2064027.
30. Feng, R, Anderson G, Xiao G, Elliot G, Leoni L, Lapara MY, Roodman GD, and Lentzsch S. SDX-308, a non-steroidal anti-inflammatory agent, inhibits NF-kB activity resulting in strong inhibition of osteoclast formation/activity and multiple myeloma cell growth. Blood. 2007; 109(3): 2130-2138.
31. Yu S, Franceschi RT, Luo M, Zhang X, Jiang D, Lai Y, Jiang Y, Zhang J, Xiao G. Parathyroid hormone increases activating transcription factor 4 expression and activity in osteoblasts: requirement for osteocalcin gene expression. Endocrinology. 2008; 149(4): 1960-8. PMCID: PMC2276723.
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33. Chen D, Xiao G, Zhang M, Xing L, and Jonason JH. Post-translational regulation of Runx2 in bone cells. J Dent Res. 2008; 88(8): 693-703.
34. Franceschi RT, Ge C, Xiao G, Roca H, Jiang D. Transcriptional regulation of osteoblasts. Cells Tissues Organs. 2009;189(1-4):144-152.
35. Yu S, Jiang Y, Galson DL, Luo M, Lai Y, Lu Y, Ouyang HJ, Zhang J, Xiao G. General transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2. J Biol Chem. 2008; 283(9): 5542-53. PMCID: PMC2736298.
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37. Liu Y, Yuan Y, Li Y, Zhang J, Xiao G, Vodovotz Y, Billiar TR, Wilson M, Fan J. Interacting neuro-endocrine, innate, and acquired immune pathways regulate neutrophil from bone marrow following hemorrhage shock. J Immnol. 2009;182(1):572-580. PMCID: PMC2610356.
38. Cai, Z, Chen Q, Chen J, Lu Y, Xiao G, Wu Z, Zhou Q, Zhang J. Monocyte chemotactic protein-1 promotes lung cancer-induced bone resorptive lesion in vivo. Neoplasia. 2009;11(3):228-36. PMCID: PMC2647725.
39. Yu S, Franceschi RT, Luo M, Fan J, Jiang D, Cao H, Lai Y, Zhang J, Patrene K, Hankenson KD, Roodman GD, Xiao G. Critical role of activating transcription factor 4 in the anabolic actions of PTH in bone. PLoS One. 2009, Oct 23;4(10):e7583. PMCID: PMC2762317. (This paper was listed as the "Not to be Missed" paper in the November (2009) issue of the IBMS BoneKEy. BoneKEy is published by the International Bone & Mineral Society).
40. Ge C, Xiao G (co-first author), Jiang D, Yang Q, Hatch NE, and Franceschi RT. Identification and functional characterization of extracellular-regulated kinase/MAPK phosphorylation sites in the Runx2 transcription factor. J Biol Chem. 2009; 284(47):32533-43. PMCID: PMC2781667.
41. Li Y, Xiang M, Yuan Y, Xiao G, Zhang J, Vodovotz Y, Billiar TR, Wilson MA, and Fan J. HMGB1 upregulation of TLR2 augments hemorrhagic shock-Induced ICAM-1 expression in lung endothelial cells. Am J Physiol Regul Integr Comp Physiol. 2009; 297(6):R1670-80, PMCID: PMC2803625.
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43. Wu, Z, Jiao P, Huang, X, Feng Y, Feng B, Yang S, Hwang P, Du J, Hall RK, Xiao G, Xu H. MAP kinase phosphatase 3 regulates glucose homeostasis through dephosphorylation of FOXO1 in mice. J Clin Invest. 2010 Nov 1;120(11):3901-11. PMCID: PMC2964981.
44. Xiang M, Yin L, Li Y, Xiao G, Vodovotz Y, Billiar TR, Wilson MA, and Fan J. Hemorrhagic shock activates lung endothelial NAD(P)H oxidase via neutrophil NADPH oxidase. Am J Respir Cell Mol Biol. 2011 Mar;44(3):333-40. PMCID: PMC3095934.
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47. Danciu TH, Li Y, Koh A, Xiao G, McCauley LK, Franceschi RT. The basic helix loop helix transcription factor Twist1 is a novel regulator of ATF4 in osteoblasts. J Cell Biochem. 2011;113(1):70-9. PMCID: PMC3414260.
48. D'Souza S, Del Prete D, Jin S, Sun Q, Huston AJ, Kostov FE, Sammut B, Hong CS, Anderson JL, Patrene KD, Yu S, Velu CS, Xiao G, Grimes HL, Roodman GD, Galson DL. Gfi-1 expressed in bone marrow stromal cells is a novel osteoblast suppressor in patients with multiple myeloma bone disease. Blood. 2011;118(26):6871-80. PMCID: PMC3245209.
49. Tang W, Yang F, Li Y, de Crombrugghe B, Jiao H, Xiao G, and Zhang C. Transcriptional regulation of vascular endothelial growth factor (VEGF) by osteoblast-specific transcription factor osterix (Osx) in osteoblasts. J Biol Chem. 2012 Jan 13;287(3):1671-8. PMCID: PMC3265850.
50. Xiang M, Yuan Y, Fan L, Li Y, Li A, Yin L, Scott MJ, Xiao G, Billiar TR, Wilson MA, Fan J. Role of Macrophages in Mobilization of Hematopoietic Progenitor Cells From Bone Marrow After Hemorrhagic Shock. Shock. 2012 May;37(5):518-523. PMCID: PMC3328610.
51. Li X, Ellman MB, Kroin JS, Chen D, Yan D, Mikecz K, Kc R, Xiao G, Stein GS, Kim SG, Cole B, van Wijnen AJ, Im HJ. Species-specific biological effects of FGF-2 in articular cartilage: Implication for distinct roles within the FGF receptor family. J Cell Biochem. 2012 Jul;113(7):2532-42. PMCID: PMC3349778.
52. Xiao G*, Cheng H, Cao H, Chen K, Tu Y, Yu S, Jiao H, Yang S, Im HJ, Chen D, Chen J, Wu C*. Critical role of Filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling. J Biol Chem. 2012 June 15;287(25):21450-60. PMCID: PMC3375566.
53. Ellman MB, Kim JS, An HS, Chen D, Ranjan KC, An J, Dittakavi T, van Wijnen AJ, Cs-Szabo G, Li X, Xiao G, An S, Kim SG, Im HJ. Toll-like receptor adaptor signaling molecule MyD88 on intervertebral disc homeostasis: in vitro, ex vivo studies. Gene. 2012 Sep 1;505(2):283-90, PMCID: PMC3518428.
54. Yan D, Chen D, Xiao G, van Wijnen A, Im HJ. Bovine lactoferricin, an antimicrobial peptide, is anti-inflammatory and anti-catabolic in human articular cartilage and synovium. J Cell Physiol. 2013 Feb;228(2):447-56, PMCID: PMC3463726.
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56. Yu S, Sharma R, Nie D, Jiao H, Lai Y, Fan J, Im HJ, Chen D, Wang Q, Xiao G. ADAR1 is required for osteoblast differentiation and bone homeostasis. Gene. 513 (2013) 101–110. PMCID: PMC3514579.
57. Yu S, Zhu K, Lai Y, Zhao Z, Fan J, Im HJ, Chen D, Xiao G. ATF4 promotes β-catenin expression and osteoblastic differentiation of bone marrow mesenchymal stem cells. Int J Biol Sci. 2013; 9(3):256-266. PMCID: PMC3596711.
58. Xu P, Wen Z, Shi X, Li Y, Fan L, Xiang M, Li A, Scott MJ, Xiao G, Li S, Billiar TR, Wilson MA, Fan J. Hemorrhagic shock augments Nlrp3 inflammasome activation in the lung through impaired pyrin induction. J Immunol. 2013 May 15;190(10):5247-55. PMCID: PMC3646900.
59. Kim JS, Ellman MB, Yan D, An HS, Kc R, Li X, Chen D, Xiao G, Cs-Zabo G, Hoskin DW, Buechter DD, van Wijnen AJ, Im HJ. Lactoferricin mediates anti-inflammatory and anti-catabolic effects via inhibition of IL-1 and LPS activity in the intervertebral disc. J Cell Physiol. 2013 Sep;228(9):1884-96. PMCID: PMC3703102.
60. Ellman MB, Kim J, An HS, Chen D, Kc R, Li X, Xiao G, Yan D, Suh J, van Wijnen A, Wang J, Kim S, Im H. Lactoferricin enhances BMP7-stimulated anabolic pathways in intervertebral disc cells. Gene. 2013 Jul 25;524(2):282-91. PMCID: PMC3679319.
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62. Zheng L, Zhu K, Jiao H, Zhao Z, Zhang L, Liu M, Chen D, Yao Z, Xiao G. PTHrP expression in human MDA-MB-231 breast cancer cells is critical for tumor growth and survival and osteoblast inhibition. Int J Biol Sci. 2013 Aug 21;9(8):830-41. PMCID: PMC3753447.
63. Xiao G*, Zhang T, Yu S, Lee A, Calabuig-Navarro V, Ringquist S, Dong HH*. ATF4 deficiency protects against high fructose-induced hypertriglyceridemia in mice. J Biol Chem. 2013 Aug 30;288(35):25350-61. PMCID: PMC3757199.
64. Zhu K, Jiao H, Li S, Cao H, Galson DL, Zhao Z, Zhao X, Lai Y, Fan J, Im HJ, Chen D, Xiao G. ATF4 promotes bone angiogenesis by increasing VEGF expression and release in the bone environment. J Bone Miner Res.2013;28: 1870–1884. PMID: 23649506. This is an EDITOR'S CHOICE paper of September 2013 JBMR issue and highlighted with a Commentary paper ( Schipani et al. J Bone Miner Res. 2013;28:1866-1869. DOI: 10.1002/jbmr.2045).
65. Cao H, Zhu K, Qiu L, Li S, Niu H, Hao M, Yang S, Zhao Z, Lai Y, Anderson JL, Fan J, Im HJ, Chen D, Roodman GD, Xiao G. Critical role of AKT in myeloma-induced osteoclast formation and osteolysis. J Biol Chem. 2013 Oct 18;288(42):30399-410. PMCID: PMC3798504.
66. Yan D, Kc R, Chen D, Xiao G, Im H. Bovine lactoferricin-induced anti-inflammation is, in part, via upregulation of IL-11 by secondary activation of STAT3 in human articular cartilage. J Biol Chem. 2013 Nov 1;288(44):31655-69. PMID: 24036113.
67. Wang B, Jin H,