田君，博士，南方科技大学医学院助理教授（独立PI）、副研究员、博士生导师。2018年博士毕业于加拿大麦吉尔大学，2019-2023年在美国哈佛医学院麻省总医院从事博士后研究。2023年8月加入南方科技大学医学院。主要研究领域为癌症的靶向和免疫治疗，在寻找药物耐药性的机制，研究和开发新的联合治疗策略，肿瘤类器官模型的建立和药物测试等方面取得了一系列成果。近年来共发表SCI论文十余篇，其中第一作者或通讯作者论文发表于Nature Medicine、Molecular Cancer (In press)、Briefings in Bioinformatics、British Journal of Cancer等国际高水平期刊杂志。于2022年获得美国国立卫生院/哈佛癌症中心研究基金。回国后获得广东省珠江人才青年学者称号以及国家自然科学基金委和深圳市科创委等多项基金资助。
基础研究：（1）研究致癌信号通路对肿瘤免疫微环境的影响；（2）研究肿瘤的靶向药和免疫治疗的协同作用；（3）肿瘤靶向药物的耐药机制。以消化道肿瘤，胰腺癌等为主要研究癌种。
临床转化应用研究：通过发现新的肿瘤靶向药和免疫治疗的应答/耐药机制，设计针对不同突变型（如KRAS突变）患者的药物联合治疗方案；寻找患者对药物联合治疗反应/耐药的生物标记物。
人源肿瘤类器官模型的建立：肿瘤药物的疗效评估、机制研究和生物标志物的发现。
2009-2013 南开大学，学士
2013-2018 加拿大麦吉尔大学，博士
2023.08-至今 南方科技大学医学院，助理教授
2019-2023 美国哈佛医学院麻省总医院，博士后
2018-2019 加拿大麦吉尔大学健康中心，博士后
2018 加拿大麦吉尔大学优秀博士毕业生奖
2017 加拿大麦吉尔大学医学院优秀生产力奖
杂志Frontiers in Genetics审稿人
美国癌症研究协会会员
1. Xia Wang, Jing Wu, Aotian Xiao, Jie Wang*, Jun Tian*; Evolution of Direct RAS Inhibitors: From Undruggable Target to Clinical Breakthroughs, Molecular Cancer, 2025 (In press)
2. Liuyang Zhao , Landu Jiang , Yufeng Xie , JianHao Huang ,Haoran Xie, Jun Tian*, Dian Zhang*; scDTL: enhancing single-cell RNA-seq imputation through deep transfer learning with bulk cell information. Briefings In Bioinformatics, 2024, 25(6)
3. Ryan B Corcoran, Khanh T Do, Jeong E Kim, James M Cleary, Aparna R Parikh, Oladapo O Yeku, Niya Xiong, Colin D Weekes, Jennifer Veneris, Leanne G Ahronian, Gianluca Mauri, Jun Tian, Bryanna L Norden, Alexa G Michel, Emily E Van Seventer, Giulia Siravegna, Kyle Camphausen, Gary Chi, Isobel J Fetter, Joan S Brugge, Helen Chen, Naoko Takebe, Richard T Penson, Dejan Juric, Keith T Flaherty, Ryan J Sullivan, Jeffrey W Clark, Rebecca S Heist, Ursula A Matulonis, Joyce F Liu*, Geoffrey I Shapiro*; Phase I/II Study of Combined BCL-xL and MEK Inhibition with Navitoclax and Trametinib in KRAS or NRAS Mutant Advanced Solid Tumors. Clinical Cancer Research, 2024, 30(9), 1739-1749.
4. Jun Tian; Jonathan H. Chen; Sherry X. Chao; Karin Pelka; Marios Giannakis; Julian Hess; Kelly Burke; Vjola Jorgji; Princy Sindurakar; Jonathan Braverman; Arnav Mehta; Tomonori Oka; Mei Huang; David Lieb; Maxwell Spurrell; Jill N. Allen; Thomas A. Abrams; Jeffrey W. Clark; Andrea C. Enzinger; Peter C. Enzinger; Samuel J. Klempner; Nadine J. McCleary; Jeffrey A. Meyerhardt; David P. Ryan; Matthew B. Yurgelun; Katie Kanter; Emily E. Van Seventer; Islam Baiev; Gary Chi; Joy Jarnagin; William B. Bradford; Edmond Wong; Alexa G. Michel; Isobel J. Fetter; Giulia Siravegna; Angelo J. Gemma; Arlene Sharpe; Shadmehr Demehri; Rebecca Leary; Catarina D. Campbell; Omer Yilmaz; Gad A. Getz; Aparna R. Parikh; Nir Hacohen; Ryan B. Corcoran ; Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trial, Nature Medicine, 2023, 29: 458-466
5. Yi Sun; Or-yam Revach; Seth Anderson; Emily A. Kessler; Clara H. Wolfe; Anne Jenney; Caitlin E. Mills; Emily J. Robitschek; Thomas G. R. Davis; Sarah Kim; Amina Fu; Xiang Ma; Jia Gwee; Payal Tiwari; Peter P. Du; Princy Sindurakar; Jun Tian; Arnav Mehta; Alexis M. Schneider; Keren Yizhak; Moshe Sade-Feldman; Thomas LaSalle; Tatyana Sharova; Hongyan Xie; Shuming Liu; William A. Michaud; Rodrigo Saad-Beretta; Kathleen B. Yates; Arvin Iracheta-Vellve; Johan K. E. Spetz; Xingping Qin; Kristopher A. Sarosiek; Gao Zhang; Jong Wook Kim; Mack Y. Su; Angelina M. Cicerchia; Martin Q. Rasmussen; Samuel J. Klempner; Dejan Juric; Sara I. Pai; David M. Miller; Anita Giobbie-Hurder; Jonathan H. Chen; Karin Pelka; Dennie T. Frederick; Susanna Stinson; Elena Ivanova; Amir R. Aref; Cloud P. Paweletz; David A. Barbie; Debattama R. Sen; David E. Fisher; Ryan B. Corcoran; Nir Hacohen; Peter K. Sorger; Keith T. Flaherty; Genevieve M. Boland; Robert T. Manguso; Russell W. Jenkins ; Targeting TBK1 to overcome resistance to cancer immunotherapy, Nature, 2023, 615(7950): 158-167
6. Tian, Jun; Wang, Vivian; Wang, Ni; Khadang, Baharak; Boudreault, Julien; Bakdounes, Khldoun; Ali, Suhad; Lebrun, Jean-Jacques ; Identification of MFGE8 and KLK5/7 as mediators of breast tumorigenesis and resistance to COX-2 inhibition, BREAST CANCER RESEARCH, 2021, 23(1)
7. Shams, Anwar; Binothman, Najat; Boudreault, Julien; Wang, Ni; Shams, Fuad; Hamam, Dana; Tian, Jun; Moamer, Alaa; Dai, Meiou; Lebrun, Jean-Jacques; Ali, Suhad ; Prolactin receptor-driven combined luminal and epithelial differentiation in breast cancer restricts plasticity, stemness, tumorigenesis and metastasis, ONCOGENESIS, 2021, 10(1)
8. Jun Tian; Fatmah Al Raffa; Meiou Dai; Alaa Moamer; Baharak Khadang; Ibrahim Y.Hachim; Khldoun Bakdounes; Suhad Ali; Bertrand Jean-Claude; Jean-Jacques Lebrun ; Dasatinib sensitises triple negative breast cancer cells to chemotherapy by targeting breast cancer stem cells, British Journal of Cancer, 2018, 119(12): 1495-1507
9. Jun Tian; Amal A.Al-Odaini; Yun Wang; Juliana Korah; Meiou Dai; Lan Xiao; Suhad Ali; Jean-Jacques Lebrun ; KiSS1 gene as a novel mediator of TGFβ-mediated cell invasion in triple negative breast cancer, Cellular Signalling, 2018, 42: 10
10. Jun Tian; Mahmood Y.Hachim; Ibrahim Y.Hachim; Meiou Dai; Chieh Lo; Fatmah Al Raffa; Suhad Ali; Jean Jacques Lebrun ; Cyclooxygenase-2 regulates TGFβ-induced cancer stemness in triplenegative breast cancer, Scientific Reports, 2017, 7: 40258
11. Hongru Zhang; Zheng Li; Li Wang; Gaofei Tian; Jun Tian; Zishan Yang; Guangchao Cao; Hong Zhou; Liqing Zhao; Zhenzhou Wu; Zhinan Yin ; Critical Role of Myeloid-Derived Suppressor Cells in Tumor-Induced Liver Immune Suppression through Inhibition of NKT Cell Function, Frontiers in Immunology, 2017, 8(129)
12. Laure Humbert; Mostafa Ghozlan; Lucie Canaff; Jun Tian; Jean-Jacques Lebrun ; The leukemia inhibitory factor (LIF) and p21 mediate the TGFβ tumor suppressive effects in human cutaneous melanoma, BMC Cancer, 2015, 15(1): 200
13. Jimin Guo; Lucie Canaff; Charles Vincent Rajadurai; Nadège Fils-Aimé; Jun Tian; Meiou Dai; Juliana Korah; Manuel Villatoro; Morag Park; Suhad Ali; Jean-Jacques Lebrun ; Breast cancer anti-estrogen resistance 3 inhibits transforming growth factor β/Smad signaling and associates with favorable breast cancer disease outcomes, Breast Cancer Research, 2014, 16(6): 476