Currently a Research Assistant Professor at the Institute of Frontier Biotechnology and a Guest Independent Researcher at the Max Planck Institute for Biology of Ageing in Germany. Graduated from Sun Yat-sen University in 2012 and conducted research at the Max Planck Institute for Biology of Ageing from 2014 to 2023. His research focuses on intestinal metabolism and immune homeostasis in ageing, with a particular interest in the biological mechanisms underlying sex differences and responses to ageing intervention. Based on these insights, he works on the development of precision anti-ageing natural products and pharmaceuticals.  

He has published extensively in leading journals, including Nature, Nature Aging, eLife, PNAS and Aging. His research on the "Rapamycin Anti-Ageing Trilogy" was selected as a 2022 Research Highlight by the Max Planck Society. He also serves as Vice Chair of the Longevity Development Committee of the Chinese Society of Gerontology and Geriatrics and is a Youth Editorial Board Member of Life Medicine. In addition, he is a peer reviewer for prestigious journals, including eLife, EMBO Reports, and Science Advances.  

His drug screening platform for ageing-related diseases won first place at the 2022 LongHack International Anti-Ageing Entrepreneurship Competition and was subsequently selected for incubation by the Max Planck Innovation in 2023, securing multi-million-funding.

1. Mechanisms of Aging and Sex Differences

2. Research and Industrialization of Natural Products and Pharmaceuticals for Ageing Intervention

3. Development of High-Throughput Compound Screening Technologies

· PhD in Biochemistry and Molecular Biology, Sun Yat-sen University (September 2007 – June 2012)

· BSc in Chemistry, Sun Yat-sen University (September 2003 – June 2007)

· Research Assistant Professor / Associate Researcher, Institute of Advanced Biotechnology & School of Medicine, Southern University of Science and Technology (January 2024 – Present)

· Independent Researcher, Max Planck Institute for Biology of Ageing, Germany (December 2022 – November 2023)

· EMBO & Marie Curie Fellow, Postdoctoral Researcher, Max Planck Institute for Biology of Ageing, Germany (May 2014 – November 2022)

· Assistant Researcher (Part-time), Sun Yat-sen University (June 2013 – April 2014)

· 2023 – Highlight from the 2022 Yearbook of the Max Planck Society

· 2023 – Selected Team for Max!mize, the Max Planck Innovation Incubator (Co-founder, Selected Project: FlyScreen)

· 2022 – Talent for Germany, featured on the official website of the German Federal Foreign Office (Deutschland.de)

· 2022 – Early Career Bursary, Biochemical Society, UK

· 2022 – Champion, LongHack International Anti-Ageing Entrepreneurship Competition (Team Lead, Awarded Project: SexAge)

· 2021 – European Crucible Fellow, European Future Research Leader

· 2021 – Best Poster Prize, Biochemical Society & British Society for Research on Ageing (BSRA), UK

· 2021 – Outstanding Scholar, Franco-German Association for Chinese Students & Scholars

· 2014-2016 – EMBO Long-term Fellowship & Marie Curie Fellow, European Molecular Biology Organization (EMBO)

Vice Chair, Longevity Development Committee, Chinese Society of Gerontology and Geriatrics

Youth Editorial Board Member, Life Medicine

Lecturer, Geneva Longevity Science College (GCLS), Switzerland

1. Yu-Xuan Lyu (吕宇轩) #*, Qiang Fu#, Dominika Wilczok#, Kejun Ying#, Aaron King, Adam Antebi, Aleksandar Vojta, Alexandra Stolzing, Alexey Moskalev, Anastasia Georgievskaya, Andrea B Maier, Andrea Olsen, Anja Groth, Anna Katharina Simon, Anne Brunet, Aisyah Jamil, Anton Kulaga, Asif Bhatti, Benjamin Yaden, Bente Klarlund Pedersen, Björn Schumacher, …, Thomas A Rando, Tim R Peterson, Tina Woods, Tony Wyss-Coray, Toren Finkel, Tzipora Strauss, Vadim N Gladyshev, Valter D Longo, Varun B Dwaraka, Vera Gorbunova, Victoria A Acosta-Rodríguez, Vincenzo Sorrentino, Vittorio Sebastiano, Wenbin Li, Yousin Suh, Alex Zhavoronkov*, Morten Scheibye-Knudsen*, Daniela Bakula*. Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity. Aging, 2024, 16 (20), p12955-12976. doi: 10.18632/aging.206135

2. Enric Ureña, Bowen Xu, Jennifer C Regan, Magda L Atilano, Lucy J Minkley, Danny Filer, Yu-Xuan Lu (吕宇轩), Ekin Bolukbasi, Mobina Khericha, Nazif Alic, Linda Partridge*. Trametinib ameliorates aging-associated gut pathology in Drosophila females by reducing Pol III activity in intestinal stem cells. PNAS, 2024, 121 (4) e2311313121. doi: 10.1073/pnas.2311313121

3. Cédric Debès§, Antonios Papadakis§, Sebastian Grönke§, Özlem Karalay§, Luke S Tain, Athanasia Mizi, Shuhei Nakamura, Oliver Hahn, Carina Weigelt, Natasa Josipovic, Anne Zirkel, Isabell Brusius, Konstantinos Sofiadis, Mantha Lamprousi, Yu-Xuan Lu (吕宇轩), Wenming Huang, Reza Esmaillie, Torsten Kubacki, Martin R Späth, Bernhard Schermer, Thomas Benzing, Roman-Ulrich Müller, Adam Antebi*, Linda Partridge*, Argyris Papantonis*, Andreas Beyer*. Ageing-associated changes in transcriptional elongation influence longevity. Nature. 2023; 616: 814-821. doi: 10.1038/s41586-023-05922-y

4. Jennifer C Regan*§, Yu-Xuan Lu (吕宇轩) *§, Enric Ureña, Ralf Meilenbrock, James H Catterson, Disna Kißler, Jenny Fröhlich, Emilie Funk and Linda Partridge*. Sexual identity of enterocytes regulates autophagy to determine intestinal health, lifespan and responses to rapamycin. Nature Aging. 2022; 2: 1145–1158. doi: 10.1038/s43587-022-00308-7

5. Paula Juricic§, Yu-Xuan Lu (吕宇轩) §, Thomas Leech§, Lisa F Drews, Jonathan Paulitz, Jiongming Lu, Tobias Nespital, Sina Azami, Jennifer C Regan, Emilie Funk, Jenny Fröhlich, Sebastian Grönke and Linda Partridge*. Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy. Nature Aging. 2022; 2: 824–836. doi: 10.1038/s43587-022-00278-w

6. Yu-Xuan Lu (吕宇轩), Jennifer C Regan, Jacqueline Eßer, Lisa F Drews, Thomas Weinseis, Julia Stinn, Oliver Hahn, Richard A Miller, Sebastian Grönke and Linda Partridge*. A TORC1-histone axis regulates chromatin organisation and noncanonical induction of autophagy to ameliorate ageing. eLife. 2021; 62233. doi:10.7554/eLife.62233

7. Yu-Xuan Lu (吕宇轩), David Denlinger* and Wei-Hua Xu*. Polycomb repressive complex 2 (PRC2) protein ESC regulates insect developmental timing by mediating H3K27me3 and activating prothoracicotropic hormone gene expression. The Journal of Biological Chemistry. 2013 288(32): 23554-64. doi: 10.1074/jbc.M113.482497

8. Yao Zhang, Yu-Xuan Lu (吕宇轩), Jian Liu, Cui Yang, Qili Feng and Wei-Hua Xu*. A regulatory pathway, ecdysone-transcription factor Relish-cathepsin L, is involved in insect fat body dissociation. PLOS Genetics. 2013; 9(2): e1003273. doi: 10.1371/journal.pgen.1003273

9. Wei-Hua Xu*, Yu-Xuan Lu (吕宇轩) and David L Denlinger*. Cross-talk between the fat body and brain regulates insect developmental arrest. Proc. Natl. Acad. Sci. U S A. 2012; 109(36): 14687-92 (2012). doi: 10.1073/pnas.1212879109

10. Yu-Xuan Lu (吕宇轩) and Wei-Hua Xu*. Proteomic and phosphoproteomic analysis at diapause initiation in the cotton bollworm, Helicoverpa armigera. Journal of Proteome Research. 2010; 9(10): 5053-64. doi: 10.1021/pr100356t