生物化学系 - 南方科技大学医学院

2023年，我系教师在Nature Chemical Biology，Molecular Cell, Nature Communications, Science Advances， Cell discovery等高水平期刊已发表论文超过40篇。

2024

2023

2022

2021

Cui, N., Zhang, J. T., Li, Z., Wei, X. Y., Wang, J. & Jia, N. (2024) Tetramerization-dependent activation of the Sir2-associated short prokaryotic Argonaute immune system, Nat Commun. 15, 8610.
Broer, A., Hu, Z., Kukulowicz, J., Yadav, A., Zhang, T., Dai, L., Bajda, M., Yan, R. & Broer, S. (2024) Cryo-EM structure of ACE2-SIT1 in complex with tiagabine, J Biol Chem. 300, 107687.
Au, M. T., Ni, J., Tang, K., Wang, W., Zhang, L., Wang, H., Zhao, F., Li, Z., Luo, P., Lau, L. C., Chan, P. K., Luo, Zhou, B., Zhu, L., Zhang, C. Y., Jiang, T., Lauwers, M., Chan, J. F., Yuan, S. & Wen, C. (2024) Publisher Correction: Blockade of endothelin receptors mitigates SARS-CoV-2-induced osteoarthritis, Nat Microbiol.
Huang, Y., Wang, Q., Zhou, W., Jiang, Y., He, K., Huang, W., Feng, Y., Wu, H., Liu, L., Pan, Y., Huang, Y., Chen, Z., Li, W., Huang, Y., Lin, G., Zhang, Y., Ren, Y., Xu, K., Yu, Y., Peng, Y., Pan, X., Pan, S., Hu, H. & Hu, Y. (2024) Prenatal p25-activated Cdk5 induces pituitary tumorigenesis through MCM2 phosphorylation-mediated cell proliferation, Neoplasia. 57, 101054.
Yang, H., Guo, H., Wang, A., Cao, L., Fan, Q., Jiang, J., Wang, M., Lin, L., Ge, X., Wang, H., Zhang, R., Liao, M., Yan, R., Ju, B., and Zhang, Z. (2024) Structural basis for the evolution and antibody evasion of SARS-CoV-2 BA.2.86 and JN.1 subvariants. Nat Commun 15, 7715
Xu, J., Hu, Z., Dai, L., Yadav, A., Jiang, Y., Broer, A., Gardiner, M. G., McLeod, M., Yan, R., and Broer, S. (2024) Molecular basis of inhibition of the amino acid transporter B(0)AT1 (SLC6A19). Nat Commun 15, 7224
Ding, Z., Ma, G., Zhou, B., Cheng, S., Tang, W., Han, Y., Chen, L., Pang, W., Chen, Y., Yang, D., and Cao, H. (2024) Targeting miR-29 mitigates skeletal senescence and bolsters therapeutic potential of mesenchymal stromal cells. Cell Rep Med 5, 101665
Zhang, J., Chen, X., Chen, C., Li, F., Song, X., Liu, C., Liao, K., Su, M. Y., Tan, C. S. H., Fang, L., and Rao, H. (2024) Distinct Amino Acid-Based PROTACs Target Oncogenic Kinases for Degradation in Non-Small Cell Lung Cancer (NSCLC). J Med Chem 67, 13666-13680
Mao, C., Li, S., Che, J., Liu, D., Mao, X., and Rao, H. (2024) The ubiquitin ligase UBR4 and the deubiquitylase USP5 modulate the stability of DNA mismatch repair protein MLH1. J Biol Chem 300, 107592
Dong, Y., Yuan, H., Ma, G., and Cao, H. (2024) Bone-muscle crosstalk under physiological and pathological conditions. Cell Mol Life Sci 81, 310
Wu, Y., Jing, H., Li, Y., Li, M., Zheng, Y., Lin, Y., Ma, G., Cao, H., and Yang, H. (2024) NOR1 promotes the osteoblastic differentiation of human periodontal ligament stem cells via TGF-beta signaling pathway. Cell Mol Life Sci 81, 338
Chen, Y., Guo, B., Ma, G., and Cao, H. (2024) Sensory nerve regulation of bone homeostasis: Emerging therapeutic opportunities for bone-related diseases. Ageing Res Rev 99, 102372
Zhang, J. T., Wei, X. Y., Cui, N., Tian, R., and Jia, N. (2024) Target ssDNA activates the NADase activity of prokaryotic SPARTA immune system. Nat Chem Biol 20, 503-511
Hu, Z., and Yan, R. (2024) Structural basis for the inhibition mechanism of LAT1-4F2hc complex by JPH203. Cell Discov 10, 73
Chen, M., Li, F., Qu, M., Jin, X., He, T., He, S., Chen, S., Yao, Q., Wang, L., Chen, D., Wu, X., and Xiao, G. (2024) Pip5k1gamma promotes anabolism of nucleus pulposus cells and intervertebral disc homeostasis by activating CaMKII-Ampk pathway in aged mice. Aging Cell, e14237
Xie, J., Liu, X., Wu, B., Chen, B., Song, Q., Guan, Y., Gong, Y., Yang, C., Lin, J., Huang, M., Tan, X., Lai, R., Lin, X., Zhang, S., Xie, X., Chen, X., Zhang, C., Yang, M., Nong, H., Zhao, X., Xia, L., Zhou, W., Xiao, G., Jiang, Q., Zou, W., Chen, D., Lu, D., Liu, J., and Bai, X. (2024) Bone transport induces the release of factors with multi-tissue regenerative potential for diabetic wound healing in rats and patients. Cell Rep Med, 101588
Chen, H., Fu, X., Wu, X., Zhao, J., Qiu, F., Wang, Z., Wang, Z., Chen, X., Xie, D., Huang, J., Fan, J., Yang, X., Song, Y., Li, J., He, D., Xiao, G., Lu, A., and Liang, C. (2024) Gut microbial metabolite targets HDAC3-FOXK1-interferon axis in fibroblast-like synoviocytes to ameliorate rheumatoid arthritis. Bone Res 12, 31
Lu, K., Zhang, M., Qin, H., Shen, S., Song, H., Jiang, H., Zhang, C., Xiao, G., Tong, L., Jiang, Q., and Chen, D. (2024) Disruption of cyclin D1 degradation leads to the development of mantle cell lymphoma. Acta Pharmaceutica Sinica B
1.Zeng, D., Umar, M., Zhu, Z., Pan, H., Lu, W. W., Xiao, G., Chen, Y., Tong, L., and Chen, D. (2024) Development of novel osteoarthritis therapy by targeting AMPK-β-catenin-Runx2 signaling. Genes & Diseases
Huang, C., Zeng, B., Zhou, B., Chen, G., Zhang, Q., Hou, W., Xiao, G., Duan, L., Hong, N., and Jin, W. (2024) Single-cell transcriptomic analysis of chondrocytes in cartilage and pathogenesis of osteoarthritis. Genes & Diseases

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Cui, N., Zhang, J. T., Li, Z., Wei, X. Y., Wang, J. & Jia, N. (2024) Tetramerization-dependent activation of the Sir2-associated short prokaryotic Argonaute immune system, Nat Commun. 15, 8610.

Broer, A., Hu, Z., Kukulowicz, J., Yadav, A., Zhang, T., Dai, L., Bajda, M., Yan, R. & Broer, S. (2024) Cryo-EM structure of ACE2-SIT1 in complex with tiagabine, J Biol Chem. 300, 107687.

Yang, H., Guo, H., Wang, A., Cao, L., Fan, Q., Jiang, J., Wang, M., Lin, L., Ge, X., Wang, H., Zhang, R., Liao, M., Yan, R., Ju, B., and Zhang, Z. (2024) Structural basis for the evolution and antibody evasion of SARS-CoV-2 BA.2.86 and JN.1 subvariants. Nat Commun 15, 7715

Xu, J., Hu, Z., Dai, L., Yadav, A., Jiang, Y., Broer, A., Gardiner, M. G., McLeod, M., Yan, R., and Broer, S. (2024) Molecular basis of inhibition of the amino acid transporter B(0)AT1 (SLC6A19). Nat Commun 15, 7224

Ding, Z., Ma, G., Zhou, B., Cheng, S., Tang, W., Han, Y., Chen, L., Pang, W., Chen, Y., Yang, D., and Cao, H. (2024) Targeting miR-29 mitigates skeletal senescence and bolsters therapeutic potential of mesenchymal stromal cells. Cell Rep Med 5, 101665

Zhang, J., Chen, X., Chen, C., Li, F., Song, X., Liu, C., Liao, K., Su, M. Y., Tan, C. S. H., Fang, L., and Rao, H. (2024) Distinct Amino Acid-Based PROTACs Target Oncogenic Kinases for Degradation in Non-Small Cell Lung Cancer (NSCLC). J Med Chem 67, 13666-13680

Mao, C., Li, S., Che, J., Liu, D., Mao, X., and Rao, H. (2024) The ubiquitin ligase UBR4 and the deubiquitylase USP5 modulate the stability of DNA mismatch repair protein MLH1. J Biol Chem 300, 107592

Dong, Y., Yuan, H., Ma, G., and Cao, H. (2024) Bone-muscle crosstalk under physiological and pathological conditions. Cell Mol Life Sci 81, 310

Wu, Y., Jing, H., Li, Y., Li, M., Zheng, Y., Lin, Y., Ma, G., Cao, H., and Yang, H. (2024) NOR1 promotes the osteoblastic differentiation of human periodontal ligament stem cells via TGF-beta signaling pathway. Cell Mol Life Sci 81, 338

Chen, Y., Guo, B., Ma, G., and Cao, H. (2024) Sensory nerve regulation of bone homeostasis: Emerging therapeutic opportunities for bone-related diseases. Ageing Res Rev 99, 102372

Zhang, J. T., Wei, X. Y., Cui, N., Tian, R., and Jia, N. (2024) Target ssDNA activates the NADase activity of prokaryotic SPARTA immune system. Nat Chem Biol 20, 503-511

Hu, Z., and Yan, R. (2024) Structural basis for the inhibition mechanism of LAT1-4F2hc complex by JPH203. Cell Discov 10, 73

Chen, M., Li, F., Qu, M., Jin, X., He, T., He, S., Chen, S., Yao, Q., Wang, L., Chen, D., Wu, X., and Xiao, G. (2024) Pip5k1gamma promotes anabolism of nucleus pulposus cells and intervertebral disc homeostasis by activating CaMKII-Ampk pathway in aged mice. Aging Cell, e14237

Lu, K., Zhang, M., Qin, H., Shen, S., Song, H., Jiang, H., Zhang, C., Xiao, G., Tong, L., Jiang, Q., and Chen, D. (2024) Disruption of cyclin D1 degradation leads to the development of mantle cell lymphoma. Acta Pharmaceutica Sinica B

1.Zeng, D., Umar, M., Zhu, Z., Pan, H., Lu, W. W., Xiao, G., Chen, Y., Tong, L., and Chen, D. (2024) Development of novel osteoarthritis therapy by targeting AMPK-β-catenin-Runx2 signaling. Genes & Diseases

Huang, C., Zeng, B., Zhou, B., Chen, G., Zhang, Q., Hou, W., Xiao, G., Duan, L., Hong, N., and Jin, W. (2024) Single-cell transcriptomic analysis of chondrocytes in cartilage and pathogenesis of osteoarthritis. Genes & Diseases