陈国安，南科大医学院副教授，博士生导师。1986年毕业于西安交通大学医学院医疗系，1992年获西安交通大学医学院呼吸专业硕士学位。1999年获协和医科大学肿瘤学博士学位。1986至1996年其间就职于西安交通大学医学院第二附属医院呼吸内科，先后任住院医师和主治医师。2000年至2018年在美国密歇根大学(UniversityofMichigan)医学院先从事肿瘤学博士后研究，以后历任讲师，研究助理教授和研究副教授。主要研究方向是肿瘤分子生物学，功能基因组学及生物信息学。应用高通量技术如蛋白质谱，基因表达芯片，单核苷酸突变（SNP）芯片，miRNA芯片以及核苷酸二代测序等研究肺癌组织及血中蛋白，RNA及DNA的变化，探讨这些分子在肿瘤发生发展及转移中的作用及分子机理以及其在临床诊断，预后判断和治疗中的价值。作为项目主持人或主要成员承担过省,国家自然科学基金和美国国家或其他基金研究项目10余项。拥有3项转化医学有关的专利，是20余SCI杂志的审稿专家。发表研究论文110余篇，其中SCI论文90余篇，影响因子（IF）大于10的有39篇，总影响因子超过920。作为第一作者(含共第一)或通讯作者有50余篇。作为第一作者的单篇论文最高引用超过千次，论文总引超过万次，h-index49,i10-index72(Google scholar)。
肺癌分子生物学
肺癌功能基因组学
肺癌非编码RNA
肺癌转移和耐药的机制研究
2000.03-2003.01，肿瘤学博士后研究，美国密歇根大学医学院
1996.9-1999.6，肿瘤学 博士，中国协和医科大学/中国医学科学院
1988.09-1992.06，呼吸专业 硕士，西安交通大学
1981.09-6/1986.06，临床医学 学士，西安交通大学
2018.10 - 至今 副教授，南方科技大学医学院
2017.09 - 2018.10 研究副教授，美国密歇根大学医学院
2010.09 - 2017.08 研究助理教授，密歇根大学医学院
2004.11 - 2010.08 讲师，密歇根大学医学院
2003.02 - 2004.10 Research Associate，密歇根大学医学院
1986.07 - 1996.08 住院医师/主治医师，西安交通大学大学第二附属医院
近5年发表论文：
1. XiaoL,LiY,ZengX,ZhouZ,HuS,ZhangS,ZhouY,ZhangZ,ZhaoH,ZhaoH,BeerDG,MaoR*,ChenG*.SilencingofLOC389641impairscellproliferationandinducesautophagyviaEGFR/METsignalinginlungadenocarcinoma.Aging-US(AlbanyNY).2020Dec9;12.doi:10.18632/aging.202286.Onlineaheadofprint.2021,13(2),PMID:33318313(*Correspondingauthor)(IF:5.68)
2. XianJ,WangS,JiangY,LiL,CaiL,ChenP,LiuY,ZengX,ChenG,DingC,HoffmanRM,JiaL,ZhaoH,ZhangY.OverexpressedNEDD8asapotentialtherapeutictargetinesophagealsquamouscellcarcinoma.CancerBiolMed.2021Mar18:j.issn.2095-3941.2020.0484.doi:10.20892/j.issn.2095-3941.2020.0484.Onlineaheadofprint.PMID:33733647(IF:4.25)
3. YangX,SuW,LiY,ZhouZ,ZhouY,ShanH,HanX,ZhangM,ZhangQ,BaiY,GuoC,YangS*,BeerDG,ChenG*.MiR-22-3psuppressescellgrowthviaMET/STAT3signalinginlungcancer.AmJTranslRes.2021Mar15;13(3):1221-1232.eCollection2021.PMID:33841651(*Correspondingauthor)(IF:4.06)
4.RobinsonAD,ChakravarthiBVSK,AgarwalS,ChandrashekarDS,DavenportML,ChenG,ManneU,BeerDG,EdmondsMD,VaramballyS.CollagenmodifyingenzymeP4HA1isoverexpressedandplaysaroleinlungadenocarcinoma.TranslOncol.2021May25;14(8):101128.doi:10.1016/j.tranon.2021.101128.Onlineaheadofprint.PMID:34049151(IF:4.24)
5.ShiJ,LvX,ZengL,LiW,ZhongY,YuanJ,DengS,LiuB,YuanB,ChenY,MingZ,YangX,FangP,YangS,ChenG.CircPVT1promotesproliferationoflungsquamouscellcarcinomabybindingtomiR-30d/e.JExpClinCancerRes.2021Jun10;40(1):193.doi:10.1186/s13046-021-01976-w.PMID:34112238(IF:11.16)
6.GongL,ShuJ,ChenX,PanH,ChenG,BiY,CuiD,LiX,LiuD,WangL,WangY,LiuP,XiongX,ZhaoY.DEPTORinhibitslungtumorigenesisbyinactivatingtheEGFR-mTORsignals.CancerLett.2021Jul25:S0304-3835(21)00356-6.doi:10.1016/j.canlet.2021.07.031.Onlineaheadofprint.PMID:34320372(IF:8.68)
7.LiuW,ZhouZ,LiY,XuJ,ShenY,LuoS,ZhouY,WuX,ZhaoH,BeerDG,HeY*,ChenG*.CSE1LsilencingimpairstumorprogressionviaMET/STAT3signalinginlungcancer.AmJCancerRes.2021Sep15;11(9):4380-4393.eCollection2021.PMID:3465989(*Correspondingauthor)(IF:6.16)
8.DuC,PengY,HeY,ChenG,ChenH.LowlevelsofBRCA1proteinexpressionpredictaworseprognosisinstageI-IIcoloncancer.IntJBiolMarkers.2021Feb14:1724600820986572.doi:10.1177/1724600820986572.Onlineaheadofprint.PMID:33583275(IF:1.75)
9.JiangY,ChengW,LiL,ZhouL,LiangY,ZhangW,ChenW,WangS,ZhaoH,ChenG,ZhouW,JiG,ZhangY,HoffmanRM,WangM,JiaL.Effectivetargetingoftheubiquitin-likemodifierNEDD8forlungadenocarcinomatreatment.CellBiolToxicol.2020Aug;36(4):349-364.doi:10.1007/s10565-019-09503-6.Epub2020Jan6.PMID:31907687.(IF:6.69).
10. LyuX,ZengL,ZhangH,KeY,LiuX,ZhaoN,YuanJ,ChenG,YangS.HydroxychloroquinesuppresseslungtumorigenesisviainducingFoxO3anucleartranslocationthroughSTAT3inactivation.LifeSci.2020Apr1;246:117366.doi:10.1016/j.lfs.2020.117366.Epub2020Jan28.PMID:32001266.(IF:5.04)
11. HuangW,RayP,JiW,WangZ,NancarrowD,ChenG,GalbánS,LawrenceTS,BeerDG,RehemtullaA,RamnathN,RayD.ThecytochromeP450enzymeCYP24A1increasesproliferationofmutantKRAS-dependentlungadenocarcinomaindependentofitscatalyticactivity.JBiolChem.2020May1;295(18):5906-5917.doi:10.1074/jbc.RA119.011869.Epub2020Mar12.PMID:32165494.(IF:5.16).
12. BuenoR,RichardsWG,HarpoleDH,BallmanKV,TsaoMS,ChenZ,WangX,ChenG,ChirieacLR,ChuiMH,FranklinWA,GiordanoTJ,GovindanR,JoshiMB,MerrickDT,RivardCJ,SpornT,vanBokhovenA,YuH,ShepherdFA,WatsonMA,BeerDG,HirschFR.Multi-institutionalprospectivevalidationofprognosticmRNAsignaturesinearlystagesquamouslungcancer(Alliance).JThoracOncol.2020Jul24:S1556-0864(20)30558-X.doi:10.1016/j.jtho.2020.07.005.Onlineaheadofprint.PMID:32717408.(IF:15.61).
13. SunS,HeH,MaY,XuJ,ChenG,SunY,XiongX.InactivationofribosomalproteinS27-likeimpairsDNAinterstrandcross-linkrepairbydestabilizationofFANCD2andFANCI.CellDeathDis.2020Oct13;11(10):852.doi:10.1038/s41419-020-03082-9.PMID:33051438.(IF:8.47).
14. SuW,WangL,ZhaoH,HuS,ZhouY,GuoC,WuB,LiL,YangZ*,BeerDG,ChenG*.LINC00857InteractingwithYBX1toRegulateApoptosisandAutophagyviaMETandPhosphor-AMPKaSignaling.MolTherNucleicAcids.2020Oct22;22:1164-1175.doi:10.1016/j.omtn.2020.10.025.eCollection2020Dec4.PMID:33312753(*Correspondingauthor)(IF:8.89).
15. YuH,ChenZ,BallmanKV,WatsonMA,GovindanR,LancI,BeerDG,BuenoR,ChirieacLR,ChuiMH,ChenG,FranklinWA,GandaraDR,GenovaC,BrovskyKA,JoshiMM,MerrickDT,RichardsWG,RivardCJ,HarpoleDH,TsaoMS,vanBokhovenA,ShepherdFA,HirschFR.CorrelationofPD-L1ExpressionwithTumorMutationBurdenandGeneSignatureforPrognosisinEarly-StageSquamousCellLungCarcinoma.JThoracOncol.2019Jan;14(1):25-36.doi:10.1016/j.jtho.2018.09.006.PMID:30253973(IF:15.61).
16. SuW,WangL,NiuF,ZouL,GuoC,WangZ,YangX,WuJ,LuY,ZhangJ,BeerDG,YangZ*,ChenG*.LINC00857knockdowninhibitscellproliferationandinducesapoptosisviainvolvingSTAT3andMEToncogenicproteinsinesophagealadenocarcinoma.Aging-US(AlbanyNY).2019May13;11(9):2812-2821.doi:10.18632/aging.101953.PMID:31085800(*Correspondingauthor)(IF:5.68).
17. ChengG,ZhangQ,PanJ,LeeY,OuariO,HardyM,ZielonkaM,MyersCR,ZielonkaJ,WehK,ChangAC,ChenG,KrestyL,KalyanaramanB,YouM.Targetinglonidaminetomitochondriamitigateslungtumorigenesisandbrainmetastasis.NatCommun.2019May17;10(1):2205.doi:10.1038/s41467-019-10042-1.PMID:31101821(IF:14.92).
18. LiL,KangJ,ZhangW,CaiL,WangS,LiangY,JiangY,LiuX,ZhangY,RuanH,ChenG,WangM,JiaL.ValidationofNEDD8-conjugatingenzymeUBC12asanewtherapeutictargetinlungcancer.EBioMedicine.2019Jun14.doi:10.1016/j.ebiom.2019.06.005.PMID:31208947(IF:8.14)
19.YangX,ZhangQ,ZhangM,SuW,WangZ,LiY,ZhangJ,BeerDG,YangS*,ChenG*.SerummicroRNASignatureIsCapableofEarlyDiagnosisforNon-SmallCellLungCancer.IntJBiolSci.2019Jun10;15(8):1712-1722.doi:10.7150/ijbs.33986.eCollection2019.PMID:31360113(*Correspondingauthor)(IF:6.58)
20.SuW,GuoC,WangL,WangZ,YangX,NiuF,TzouD,YangX,HuangX,WuJ,ChenX,ZouL,YangZ*,ChenG*.LncRNAMIR22HGabrogationinhibitsproliferationandinducesapoptosisinesophagealadenocarcinomacellsviaactivationoftheSTAT3/c-Myc/FAKsignaling.Aging-US(AlbanyNY).2019Jul10;11.doi:10.18632/aging.102071.[Epubaheadofprint]PMID:31291201(*Correspondingauthor)(IF:5.68).
21.YinY,XieCM,LiH,TanM,ChenG,SchiffR,XiongX,SunY.TheFBXW2-MSX2-SOX2axisregulatesstemcellpropertyanddrugresistanceofcancercells.ProcNatlAcadSciUSA.2019Sep23.pii:201905973.doi:10.1073/pnas.1905973116.[Epubaheadofprint]PMID:31548378(IF:11.21)
22. YangX,SuW,ChenX,GengQ,ZhaiJ,ShanH,GuoC,WangZ,FuH,JiangH,LinJ,LagisettyKH,ZhangJ,LiY,YangS,MassionPP,BeerDG,ChangAC,RamnathN*,ChenG*.Validationofaserum4-microRNAsignatureforthedetectionoflungcancer.TranslLungCancerRes.2019Oct;8(5):636-648.doi:10.21037/tlcr.2019.09.11.PMID:31737499(*Correspondingauthor)(IF:6.5).
23. XiaYang,QiuhongZhang,WenmeiSu,MingZhang,HuShan,JieZhang,GuoanChen,ChunfangGuo,YaliLi.ExpressionlevelofserummiRNA-22anditsclinicalsignificanceinpatientswithlungcancer.InternationalJournalofRespiration.2019Sep,39(18),1373-1378.
24. ChenX,MaoR,SuW,YangX,GengQ,GuoC,WangZ,WangJ*,KrestyLA,BeerDG,ChangAC,ChenG*.CircularRNAcircHIPK3modulatesautophagyviaIR124-3p-STAT3-PRKAA/AMPKαsignalinginSTK11mutantlungcancer.Autophagy.2020Apr;16(4):659-671.doi:10.1080/15548627.2019.1634945.Epub2019Jun28.PMID:31232177(*Correspondingauthor)(IF:16.02)
25. ChockleyPJ,ChenJ,ChenG,BeerDG,StandifordTJ,KeshamouniVG.Epithelial-mesenchymaltransitionleadstoNKcell-mediatedmetastasis-specificimmunosurveillanceinlungcancer.JClinInvest.2018Jan11.PMID:29324443(IF:14.81).
26. SuW,FengS,ChenX,YangX,MaoR,GuoC,WangZ,ThomasDG,LinJ,ReddyRM,OrringerMB,ChangAC,YangZ,BeerDG,ChenG*.Silencingoflongnon-codingRNAMIR22HGtriggerscellsurvival/deathsignalingviaoncogenesYBX1,MET,andp21inlungcancer.CancerRes.2018Apr18.PMID:29669758(*Correspondingauthor)(IF:12.7).
27. GuoNL,DowlatiA,RaeseRA,DongC,ChenG,BeerDG,ShafferJ,SinghS,BokharyU,LiuL,HowingtonJ,HensingT,QianY.APredictive7-GeneAssayandPrognosticProteinBiomarkersforNon-smallCellLungCancer.EBioMedicine.2018May31.PMID:29861409(IF:8.14).
28. RaghunathanR,CeaseK,TroeschelS,ZhaoL,GrossM,ChenG,ChopraV,RamnathNImpactofStagingWithPositron-emissionTomography(PET)andComorbiditiesonManagementandSurvivalofAmericanVeteransWithStageI-IIINon-SmallCellLungCancer.AmJClinOncol.2018May;41(5):513-518,PMID:27322696(IF:2.34).
29. HeidenBT,ChenG,HermannM,BrownRKJ,OrringerMB,LinJ,ChangAC,CarrottPW,LynchWR,ZhaoL,BeerDG,ReddyRM.18F-FDGPETintensitycorrelateswithahypoxicgenesignatureandotheroncogenicabnormalitiesinoperablenon-smallcelllungcancer.PloSOne.2018Jul2;13(7):PMID:29966011(IF:3.24).
30. XuJ,ZhouW,YangF,ChenG,LiH,ZhaoY,LiuP,LiH,TanM,XiongX,SunY.Theβ-TrCP-FBXW2-SKP2axisregulateslungcancercellgrowthwithFBXW2actingasatumoursuppressor.NatCommun.2017Jan16;8:14002.PMID:28090088(IF:14.92).
31. ZhangJ,FengS,SuW,BaiS,XiaoL,WangL,ThomasDG,LinJ,ReddyRM,CarrottPW,LynchWR,ChangAC,BeerDG,GuoYM,ChenG*.OverexpressionofFAM83H-AS1indicatespoorpatientsurvivalandknockdownimpairscellproliferationandinvasionviaMET/EGFRsignalinginlungcancer.SciRep.2017Feb15;7:42819.PMID:28198463(*Correspondingauthor)(IF:4.38).
32. LiuY,BuL,LiW,WuW,WangS,DiaoX,ZhouJ,ChenG,YangS.IncreasedAAA-TOB3correlateswithlymphnodemetastasisandadvancedstageoflungadenocarcinoma.IntJBiolMarkers.2017Jun15:PMID:28623644(IF:2.66).
33. FengS,ZhangJ,SuW,BaiS,XiaoL,ChenX,LinJ,ReddyRM,ChangAC,BeerDG,ChenG*.OverexpressionofLINC00152correlateswithpoorpatientsurvivalandknockdownimpairscellproliferationinlungcancer.SciRep.2017Jun7;7(1):2982.PMID:28592840(*Correspondingauthor)(IF:4.38).
