曹阳坡, 南方科技大学医学院副教授，博士生导师，课题组独立PI。国家级（中组部）高层次青年人才，深圳市鹏城孔雀特聘专家。2020年于北京大学医学部获得博士学位，2020年至2023年在美国哈佛医学院波士顿儿童医院从事博士后研究工作。他们实验室利用一系列高通量、多组学的方法（包括但不限于AAV-MPRA，AAV-Perturb-seq, HiC, HiChIP, snMultiomics, CASAAV, bioChiP-seq等）, 重点关注心脏发育与心肌病的转录调控。近5年，曹阳坡博士以第一或通讯作者在Circulation、Circ Res、Nat Cardiovasc Res、PNAS、Dev Cell、Cardiovasc Res、Sci China Life Sci 等领域内主流期刊上发表多篇有影响力的工作。系列研究成果入选美国AHA科学专刊亮点文章， Nature CVR 亮点文章，心血管领域顶级期刊Circ Res封面文章，亮点文章等。担任中国粤港澳大湾区心脏病协会等多个协会常委或委员，国内外多本SCI期刊审稿人。
1. 心肌细胞命运调控的表观遗传学机制
2. 线粒体质量控制与心脏病理生理
3. 代谢-表观遗传互作与心血管疾病
2009年9月-2014年6月 西北农林科技大学，农学，学士
2014年9月-2020年1月 北京大学，病理生理学，博士
2020年1月 - 2023年3月 哈佛医学院波士顿儿童医院，博士后
2023年6月 - 2023年11月 南方科技大学医学院，助理教授
2023年12月- 至今 南方科技大学医学院，副教授
2023年 获国家级人才头衔
2023年 获深圳市人才头衔
2018年 北京大学学术创新奖
1. 美国心脏协会(AHA)会员
2. 国际心脏研究会(ISHR)会员
3. 中国粤港澳大湾区心脏病协会临床与基础研究分会常委
(#共同一作, *共同通讯)
1. Cao Y#, Zhang X#, Akerberg BN#, Yuan H, Sakamoto T, Xiao F, VanDusen NJ, Zhou P, Sweat ME, Wang Y, Prondzynski M, Chen J, Zhang Y, Wang P, Kelly DP, Pu WT. In Vivo Dissection of Chamber-Selective Enhancers Reveals Estrogen-Related Receptor as a Regulator of Ventricular Cardiomyocyte Identity. Circulation. 2023 Mar 14;147(11):881-896
2. Cao Y, Xu C, Ye J, He Q, Zhang X, Jia S, Qiao X, Zhang C, Liu R, Weng L, Liu Y, Liu L, Zheng M. Miro2 Regulates Inter-Mitochondrial Communication in the Heart and Protects Against TAC-Induced Cardiac Dysfunction. Circ Res. 2019 Sep 27;125(8):728-743. doi: 10.1161/CIRCRESAHA.119.315432
3. Feng Xiao#,Xiaoran Zhang#,Sarah U Morton#,Seong Won Kim,Youfei Fan, Joshua M Gorham, Huan Zhang, Paul J Berkson,Neil Mazumdar,Yangpo Cao, Jian Chen,Jacob Hagen,Xujie Liu,Pingzhu Zhou,Felix Richter,Yufeng Shen,Tarsha Ward,Bruce D Gelb,Jonathan G Seidman,Christine E Seidman*,William T Pu*.Functional dissection of human cardiac enhancers and noncoding de novo variants in congenital heart disease.Nat Genet. 2024 Feb 20. doi: 10.1038/s41588-024-01669-y. Online ahead of print.
4. Chaoshan Han#,Junjie Yang#,Tingting Yin#,Junqing An,Aijun Qiao, Yangpo Cao, Yuliang Feng,Haocheng Lu,Ying Wang,Liang Yang, Gangjian Qin*.CD63-snorkel tagging for isolation of exosomes.ScienceDirect.2023 October 26.doi: 10.1016/j.vesic.2023.100031
5. Zhou P#, VanDusen NJ#, Zhang Y#, Cao Y#, Sethi I, Hu R, Zhang S, Wang G, Ye L, Mazumdar N, Chen J, Zhang X, Guo Y, Li B, Ma Q, Lee JY, Gu W, Yuan GC, Ren B, Chen K*, Pu WT*. Dynamic changes in P300 enhancers and enhancer-promoter contacts control mouse cardiomyocyte maturation. Dev Cell. 2023 May 22;58(10):898-914.e7
6. Sweat ME#, Cao Y#, Zhang X, Burnicka-Turek O, Perez-Cervantes C, Akerberg BN, Ma Q, Wakimoto H, Gorham JM, Song MK, Trembley MA, Wang P, Lu F, Gianeselli M, Prondzynski M, Bortolin RH, Seidman JG, Seidman CE, Moskowitz IP, Pu WT. Tbx5 maintains atrial identity by regulating an atrial enhancer network. Nat Cardiovasc Res. 2023 Oct;2(10):881-898. doi: 10.1038/s44161-023-00334-7. Epub 2023 Oct 12.
7. Zhou P#, Zhang Y#, Sethi I, Ye L, Trembley MA, Cao Y, Akerberg BN, Xiao F, Zhang X, Li K, Jardin BD, Mazumdar N, Ma Q, He A, Zhou B, Pu WT. GATA4 Regulates Developing Endocardium Through Interaction With ETS1. Circ Res. 2022 Nov 11;131(11):e152-e168
8. Liu R, Xu C, Zhang W, Cao Y, Ye J, Li B, Jia S, Weng L, Liu Y, Liu L, Zheng M. FUNDC1-mediated mitophagy and HIF1α activation drives pulmonary hypertension during hypoxia. Cell Death Dis. 2022 Jul 21;13(7):634
9. Guo Y#, Cao Y#, Jardin BD#, Zhang X, Zhou P, Guatimosim S, Lin J, Chen Z, Zhang Y, Mazumdar N, Lu F, Ma Q, Lu YW, Zhao M, Wang DZ, Dong E, Pu WT. Ryanodine receptor 2 (RYR2) dysfunction activates the unfolded protein response and perturbs cardiomyocyte maturation. Cardiovasc Res. 2023 Mar 17;119(1):221-235
10. Xu C, Cao Y, Liu R, Liu L, Zhang W, Fang X, Jia S, Ye J, Liu Y, Weng L, Qiao X, Li B, Zheng M. Mitophagy-regulated mitochondrial health strongly protects the heart against cardiac dysfunction after acute myocardial infarction. J Cell Mol Med. 2022 Feb;26(4):1315-1326
11. Li B, Ye J, Liu R, Weng L, Cao Y, Jia S, Xu C, Liu Y, Yan S, Zheng M. Programmed cell death 5 improves skeletal muscle insulin resistance by inhibiting IRS-1 ubiquitination through stabilization of MDM2. Life Sci. 2021 Nov 15;285:119918
12. Guo Y#, Cao Y#, Jardin BD#, Sethi I, Ma Q, Moghadaszadeh B, Troiano EC, Mazumdar N, Trembley MA, Small EM, Yuan GC, Beggs AH, Pu WT. Sarcomeres regulate murine cardiomyocyte maturation through MRTF-SRF signaling. Proc Natl Acad Sci U S A. 2021 Jan 12;118(2):e2008861118
13. Guo Y#, Cao Y#, Jardin BD#, Mazumdar N, Guo C, Yang L, Lin J, Zhan C, Ma Q, Zhao M, Dong E, Pu WT. A shared role of the myocardin-family transcriptional coactivators in cardiomyocyte maturation. Sci China Life Sci .2023 Dec;66(12):2939-2942. doi: 10.1007/s11427-023-2385-x. Epub 2023 Aug 11.
14. Hu H, Jiang M, Cao Y, Zhang Z, Jiang B, Tian F, Feng J, Dou Y, Gorospe M, Zheng M, Zheng L, Yang Z, Wang W. HuR regulates phospholamban expression in isoproterenol-induced cardiac remodelling. Cardiovasc Res. 2020 Apr 1;116(5):944-955
15. Cao YP, Zheng M. Mitochondrial dynamics and inter-mitochondrial communication in the heart. Arch Biochem Biophys. 2019 Mar 15;663:214-219
16. Ye J, Zheng Q, Jia S, Qiao X, Cao Y, Xu C, Weng L, Zhao L, Chen Y, Liu J, Wang T, Cheng H, Zheng M. Programmed Cell Death 5 Provides Negative Feedback on Cardiac Hypertrophy Through the Stabilization of Sarco/Endoplasmic Reticulum Ca2+-ATPase 2a Protein. Hypertension. 2018 Oct;72(4):889-901
17. Weng L, Jia S, Xu C, Ye J, Cao Y, Liu Y, Zheng M. Nogo-C regulates post myocardial infarction fibrosis through the interaction with ER Ca2+ leakage channel Sec61α in mouse hearts. Cell Death Dis. 2018 May 23;9(6):612
18. Zhang CL, Chen ZJ, Feng H, Zhao Q, Cao YP, Li L, Wang JY, Zhang Y, Wu LL. C1q/tumor necrosis factor-related protein-3 enhances the contractility of cardiomyocyte by increasing calcium sensitivity. Cell Calcium. 2017 Sep;66:90-97
19. Qiao X, Jia S, Ye J, Fang X, Zhang C, Cao Y, Xu C, Zhao L, Zhu Y, Wang L, Zheng M. PTPIP51 regulates mouse cardiac ischemia/reperfusion through mediating the mitochondria-SR junction. Sci Rep. 2017 Mar 27;7:45379
20. Jia S, Qiao X, Ye J, Fang X, Xu C, Cao Y, Zheng M. Nogo-C regulates cardiomyocyte apoptosis during mouse myocardial infarction. Cell Death Dis. 2016 Oct 20;7(10):e2432
