南方科技大学医学院

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王鹏
讲席教授、博士生导师

0755-88015584

wangp6@sustech.edu.cn

第二科研楼310

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个人简介

王鹏，南方科技大学医学院讲席教授，博士生导师。中国生物物理学会糖生物学分会会长。1984年获南开大学化学理学学士学位，1990年获美国加州大学伯克利分校化学博士学位。获美国科学促进会（AAAS）会士，俄亥俄州杰出学者，佐治亚州研究联盟杰出学者荣誉称号。2022年天津市技术发明奖一等奖获得者；2021年美国糖化学界最高奖Claude S. Hudson奖获得者，是首位获此奖的中国大陆出生学者；2021年中国生物工程学会第四届张树政糖科学奖杰出成就奖获得者；2002年美国化学会糖化学部Horace S. Isbell奖获得者；2000年与C.-H. Wong 教授共同获得美国总统绿色化学奖。历任美国迈阿密大学化学系助理教授，美国韦恩州立大学化学系正教授、终生教授，美国俄亥俄州立大学生物化学与化学系讲席教授，美国佐治亚州立大学化学系讲席教授、系主任。曾兼任南开大学药学院院长（半职），建立山东大学国家糖工程技术研究中心并担任中心主任。王鹏教授的研究领域涉及核酸科学，糖科学，药物化学，药物递送材料。他在各种国际学术刊物上发表学术论著467篇（H-index 57 (Google Scholar) and 47 (Web of Science)，参与7部学术专著的编写，拥有美国和中国专利19个。

研究领域

重点从事糖化学，药物化学，糖生物学，化学生物学，糖蛋白质组学等方面的基础研究；以及天然产物的生物合成工程，酶催化反应，绿色化学，生命中活性氮和氧的化学生物学研究。

教育背景

1980-1984：中国，南开大学，化学理学学士

1985-1990：美国，加州大学伯克利分校，有机/生物有机化学博士

1991-1992：美国，加州大学伯克利分校博士后

1992-1994：美国，Scripps Research Institute 斯克里普斯研究所，博士后

工作经历

1994.08-1997.07 美国迈阿密大学化学系，助理教授

1997.07-2001.08 美国韦恩州立大学化学系，副教授;1998年获得韦恩州立大学终身教授

2001.08-2003.07 美国韦恩州立大学化学系，正教授;Barbara Ann Karmanos癌症研究所成员;韦恩州立大学药物设计研究所成员

2007.01-2019.09 山东大学国家糖工程技术中心主任

2019.09-至今南方科技大学医学院，讲席教授

获奖情况及荣誉

2021年美国化学会克劳德·哈德森奖Claude S. Hudson Award（旨在表彰碳水化合物化学在教育、研究或应用方面的杰出贡献。每两年颁发一次的奖项是在奇数年份颁发的。）

2012年美国科学促进会（AAAS）会士

2009年比尔和梅琳达门基金会的第一阶段大挑战探索奖的获得者

2002年美国化学学会糖化学部的Horace S. Isbell奖（美国化学学会每年只颁发给一位在糖化学/糖生物学领域有杰出贡献且不到41岁的科学家）

2000年与C.-H. Wong 教授共同获得美国总统绿色化学奖

2000年 Metro Detroit’s Creator from Crain’s Detroit Business

2000年美国韦恩州立大学 Career Development Chair Award

1999年 Camille和Henry Dreyfus基金会Camille Dreyfus教师学者奖

1996年美国 NIH First Independent Research Support and Transition Award

1988年 NATO 高级研究所NATO奖学金

杂志编委会成员

副主编：Organic Chemistry Frontiers (2018-至今)

编辑成员：Journal of Biological Chemistry （2014-至今）

编辑成员：American Journal of Biomedical Sciences（2008-至今）

编辑成员：Carbohydrate Research（2005-2012）

编辑成员：Applied and Environmental Microbiology（2003-至今）

编辑成员：Marine Drugs（2002-至今）

区域编辑：Current Organic Chemistry （2002-至今）

编辑成员：Medicinal Research Reviews（2001-至今）

近年代表文章

一共发表SCI论文440余篇，H-指数 57 (Google Scholar) and 47 (Web of Science) (Orcid Id: 0000-0003-3335-6794)，以下为近5年发表的论文(按时间顺序排列)

Zhao J, Yang Y, Huang H, Li D, Gu D, Lu X, Zhang Z, Liu L, Liu Y, He Y, Sun B, Wei M, Yang G, Wang X, Zhang L, Zhou X, Xing M,Wang PG“Relationship between the ABO Blood Group and the COVID-19 Susceptibility” Clinical Infectious Diseases, 2020, August 4.（IF=8.313）
Liu D, Zhang J, Zhu H, Wang M, Polizzi SJ, Jones MT, Li L, Gadi MR, Wang PG, Ma C, Huang W. “Enzymatic depolymerization of streptococcus pneumoniae type 8 polysaccharide” Carbohydr Res. 2020 May 13;495:108024.（IF=1.841）
Ma J, Li Y, Li L, Yue K, Liu H, Wang J, Xi Z, Shi M, Zhao S, Ma Q, Liu S, Guo S, Liu J, Hou L, Wang C,Wang PG, Tian Z, Xie S. “A Polyamine-Based Dinitro-Naphthalimide Conjugate as Substrates for Polyamine Transporters Preferentially Accumulates in Cancer Cells and Minimizes Side Effects in vitroand in vivo” Front Chem. 2020 Apr 9;8:166. （IF=3.693）
Li L, Guan W, Zhang G, Wu Z, Yu H, Chen X, Wang PG. “Microarray analyses of closely related glycoforms reveal different accessibilities of glycan determinants on N-glycan branches” Glycobiology. 2020 Apr 20;30(5):334-345. （IF=4.06）
Zhu H, Wang S, Liu D, Ding L, Chen C, Liu Y, Wu Z, Bollag R, Liu K, Alexander WM, Yin J, Ma C, Li L, Wang PG. “Identifying Sialylation Linkages at the Glycopeptide Level by Glycosyltransferase Labeling Assisted Mass Spectrometry (GLAMS)” Anal Chem. 2020 May 5;92(9):6297-6303.（IF=6.785）
Li Z, Zhang Q, Ashline D, Zhu Y, Lasanajak Y, Chernova T, Reinhold V, Cummings RD, Wang PG, Ju T, Smith DF, Song X. “Amplification and Preparation of Cellular O-Glycomes for Functional Glycomics” Anal Chem. 2020 Jul 13.（IF=6.785）
Zhang J, Liu D, Saikam V, Gadi MR, Gibbons C, Xuan F, Yu J, Kondengaden MS, Wen L, Wang PG, Song H. “Machine Driven Chemoenzymatic Synthesis of Glycopeptide” Angew Chem Int Ed Engl. 2020 Jul 16. （IF=12.959）
De Leoz MLA, Duewer DL, Fung A, Liu L, Yau HK, Wang, PG, Leize-Wagner E, Maier S, Zeck A, Heck AJR, Yang Y, Haselberg R, Yu YQ, Alley W, Leone JW, Yuan H, Stein SE. “NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods” Mol Cell Proteomics. 2020 Jan;19(1):11-30.（IF=4.87）
Ma, J., Li, L., Yue, K., Li, Y., Liu, H., Wang, P.G, Wang, C, Wang, J., Luo, W., Xie, S.“Bromocoumarinplatin, targeting simultaneously mitochondria and nuclei with p53 apoptosis pathway to overcome cisplatin resistance.”2020,Bioorg Chem. Mar 20;99:103768. （IF=4.381）
Purohit S, Ferris DG, Alvarez M, Tran PMH, Tran LKH, Mysona DP, Hopkins D, Zhi W, Dun B, Wallbillich JJ, Cummings RD, Wang, P.G, She JX. “Better survival is observed in cervical cancer patients positive for specific anti-glycan antibodies and receiving brachytherapy.”2020,Gynecol Oncol. Apr;157(1):181-187. （IF=4.623）
Wang S, Rong Y, Wang Y, Kong D, Wang, P.G, Chen M, Kong Y.“Homogeneous production and characterization of recombinant N-GlcNAc-protein in Pichia pastoris.”2020, Microb Cell Fact. Jan 13;19(1):7. （IF=4.187）
Liu H, Ma J, Li Y, Yue K, Li L, Xi Z, Zhang X, Liu J, Feng K, Ma Q, Liu S, Guo S, Wang, P.G, Wang C, Xie S. “Polyamine-Based Pt(IV) Prodrugs as Substrates for Polyamine Transporters Preferentially Accumulate in Cancer Metastases as DNA and Polyamine Metabolism Dual-Targeted Antimetastatic Agents.”2019, Med Chem.Dec 26;62(24):11324-11334.
Liu L, Li L, Ma C, Shi Y, Liu C, Xiao Z, Zhang Y, Tian F, Gao Y, Zhang J, Ying W, Wang, P.G, Zhang L7. “O-GlcNAcylation of Thr12/Ser56in short-form O-GlcNAc transferase (sOGT) regulates its substrate selectivity.” 2019,Biol Chem. Nov 8;294(45):16620-16633.
Liu, J., Li, S., Aslam, N.A., Zheng, F., Yang, B., Cheng, R., Wang, N., Rozovsky, S., Wang, P.G., Wang, Q. and Wang, L..“Genetically Encoding Photocaged Quinone Methide to Multitarget Protein Residues Covalently in Vivo.” 2019, Journal of the American Chemical Society,141 (24) 9458-9462
Zhang, P., Liu, P., Xu, Y., Liang, Y., Wang, P.G. and Cheng, J., "N-acetyltransferases from three different organisms displaying distinct selectivity toward hexosamines and N-terminal amine of peptides." 2019. Carbohydrate research472: 72-75.
Davies-Bolorunduro, O.F., Adeleye, I.A., Akinleye, M.O. and Wang, P.G.. “Anticancer potential of metabolic compounds from marine actinomycetes isolated from Lagos Lagoon sediment.” 2019, J Pharm Anal.Jun, 9(3):201-208. PMID:31297298
Wu, Q., Liu, F., Song, Y., Meng, Q., Zhang, X., Li, H., Sun, J., Gao, H., Wang, P.G., Kong, Y. and Chen, M. “A new strategy for high-throughput identification of human gut microbiota containing specific monosaccharide.” 2019, Sci China Life Sci.Jul, 62(7):985-987. PMID:31098892
Yang, B., Wang, N., Schnier, P.D., Zheng, F., Zhu, H., Polizzi, N.F., Ittuveetil, A., Saikam, V., DeGrado, W., Wang, Q. and Wang, P.G.. “Genetically Introducing Biochemically Reactive Amino Acids Dehydroalanine and Dehydrobutyrine in Proteins.” 2019, Journal of the American Chemical Society, PMID:31038942
Wei, M, Wang, P.G.. “Desialylation in physiological and pathological processes: New target for diagnostic and therapeutic development.” 2019, Prog Mol Biol Transl Sci,162:25-57. PMID:30905454
Wang, H, Yang, X, Zhao, C, Wang, P.G., Wang, X. “Glucose-conjugated platinum(IV) complexes as tumor-targeting agents: design, synthesis and biological evaluation.” 2019, Bioorg Med Chem. Apr 15, 27(8):1639-1645. PMID:30852077
Wang, J., Li, S., Zang, L., Zhu, H., Guo, J., Zhang, J., Wen, L., Chen, Y., Li, Y., Chen, X. and Wang, P.G.. “Production of Glycopeptide Derivatives for Exploring Substrate Specificity of Human OGA Toward Sugar Moiety.” 2019, Front Chem.Jan 14, 6:646. PMID:30693278
Hou, J., Pan, Y., Zhu, D., Fan, Y., Feng, G., Wei, Y., Wang, H., Qin, K., Zhao, T., Yang, Q. and Zhu, Y., Che, Y., Liu, Y., Cheng, J., Kong, D., Wang P.G., Shen, J., Zhao, Q.. “Targeted delivery of nitric oxide via a 'bump-and-hole'-based enzyme-prodrug pair.” 2019Nature Chemical BiologyFeb;15(2):151-160. PMID:30598545
Li, X., Ding, L., Li, X., Zhu, H., Gashash, E.A., Li, Z., Wang, P.G.and Ma, C.. “An integrated proteomic and glycoproteomic study for differences on glycosylation occupancy in rheumatoid arthritis.” 2019, Analytical and bioanalytical chemistry, pp.1-8.
Zhang, P., Liu, P., Xu, Y., Liang, Y., Wang, P.G.and Cheng, J.. “N-acetyltransferases from three differen t organisms displaying distinct selectivity toward hexosamines and N-terminal amine of peptides.” 2019, Carbohydrate Research, 472, pp.72-75.
Ma, Z., Wang, P. G.. “RecET Direct Cloning of Polysaccharide Gene Cluster from Gram-Negative Bacteria.” In Bacterial Polysaccharides. 2019, Bacterial Polysaccharides. Humana Press, pp 15-23.
Hu, X., Pang, X., Wang, P.G.and Chen, M.. “Isolation and characterization of an antioxidant exopolysaccharide produced by Bacillus sp. S-1 from Sichuan Pickles.” 2019, Carbohydrate Polymers, 204, pp.9-16.
Wang, J., Zhang, D., Wen, Y., Cao, X., Ma, J. and Wang, P.G.. “Efficient chemoenzymatic synthesis of UDP-α-6-N3-glucose.” 2019, Bioorganic & Medicinal Chemistry Letters. 29 (9), 1148-1151
Aloor A, Zhang J, Gashash E, Parameswaran A, Chrzanowski M, Ma C, Diao Y, Wang P.G, Xiao W. “Site-Specific N-Glycosylation on the AAV8 Capsid Protein” 2018, Viruses 10, 644.
Hu, X., Yang, C., Wang, P.G. and Zhang, G.L.. “ADP-heptose: A new innate immune modulator.” 2018, Carbohydrate Research. 473, pp. 123-128.
Zhang, J., Chen, C., Gadi, M.R., Gibbons, C., Guo, Y., Cao, X., Edmunds, G., Wang, S., Liu, D., Yu, J. and Wen, L., Wang, P.G.. “Machine‐Driven Enzymatic Oligosaccharide Synthesis by Using a Peptide Synthesizer.” 2018, Angewandte Chemie International Edition, 130 (51), 16880-16884.
Ma, Z., Zhang, H., Li, L., Chen, M. and Wang, P.G.. “Direct Cloning of Bacterial Surface Polysaccharide Gene Cluster for One-Step Production of Glycoconjugate Vaccine.” 2018, ACS Infectious Diseases. 5 (1), pp 74–78.
Wen, L., Edmunds, G., Gibbons, C., Zhang, J., Gadi, M.R., Zhu, H., Fang, J., Liu, X., Kong, Y. and Wang, P.G.. “Toward Automated Enzymatic Synthesis of Oligosaccharides.” 2018, Chemical Reviews, 118(17), pp.8151-8187.
Ma, Z., Zhang, H., Wang, P.G., Liu, X.W. and Chen, M.. “Peptide adjacent to glycosylation sites impacts immunogenicity of glycoconjugate vaccine.” 2018, Oncotarget, 9(1), p.75.
Li, S., Wang, J., Zang, L., Zhu, H., Guo, J., Zhang, J., Wen, L., Chen, Y., Li, Y., Chen, X. and Wang, P.G.. “Production of Glycopeptide Derivatives for Exploring Substrate Specificity of Human OGA Toward Sugar Moiety.” 2018, Frontiers in Chemistry, 6.
Ma, J., Liu, H., Xi, Z., Hou, J., Li, Y., Niu, J., Liu, T., Bi, S., Wang, X., Wang, C. and Wang, J., Wang, P.G.. “Protected and de-protected platinum (IV) glycoconjugates with GLUT1 and OCT2-mediated selective cancer targeting: demonstrated enhanced transporter-mediated cytotoxic properties in vitro and in vivo.” 2018, Frontiers in Chemistry, 6.
Yu, H., Santra, A., Li, Y., McArthur, J.B., Ghosh, T., Yang, X., Wang, P.G. and Chen, X., . “Streamlined chemoenzymatic total synthesis of prioritized ganglioside cancer antigens.” 2018Organic & Biomolecular Chemistry, 16(22), pp.4076-4080.
Wang, J., Greenway, H., Li, S., Wei, M., Polizzi, S. J., & Wang, P. G.. “Facile and Stereo-Selective Synthesis of UDP-α-D-xylose and UDP-β-L-arabinose Using UDP-Sugar Pyrophosphorylase”. 2018, Frontiers in Chemistry, May, Volume 6, Article 163.
Wang, N.; Yang, B.; Fu, C.; Zhu, H.; Zheng, F.; Kobayashi, T.;Liu, J.; Li,S.; Ma, C.; Wang, P. G.; Wang, Q.;Wang, L,; “Genetically Encoding Fluorosulphate-L-Tyrosine to React with Lysine, Histidine and Tyrosine via SuFEx in proteins in vivo” 2018,Journal of American Chemical Society140(15), 4995-4999.
Wang, S.; Zhang, Q.; Chen, C.; Guo, Y.; Gadi, M.R.; Yu, J.; Westerlind, U.; Liu,Y.; Cao, X.; Wang, P. G.; Li, L.; “Facile Chemoenzymatic Synthesis of O-mannosyl glycans” 2018, Angewandte Chemie International Edition57(30), 9268-9273.
Wen, L.; Gadi, M. R.; Zheng, Y.; Gibbons, C.; Kondengaden, S.; Zhang, J.; Wang, P. G. “Chemoenzymatic Synthesis of Unnatural Nucleotide Sugars for Enzymatic Biorthogonal Labeling” ACS Catalysis2018, 8, 7659-7666.
Yu, B.; Li, S.; Wang, J.; Zheng, Y.; Zhang, H.; Walker, M.-J.; Yuan, Z.; Zhu, H.; Zhang, J.; Wang, P. G.; Wang, B. “Biomarker-based Metabolic Labeling for Redirected and Enhanced Immune Response” ACSChemical Biology2018, 13(6), 1686-1694.
Li, J.; Li, S.; Li, Q.; Long, J.; Ma, C.; Guo, J.; Ding, Y.; Yan, C.; Li, L .;Wu, Z; Zhu, H.; Li, K.-K.; Wen, L; Zhang, Q.; Ivanov, I.; Luo, M.; Xi, R.; Long, H.; Wang, P. G.; Chen, Y. “Natural Product Micheliolide (MCL) Irreversibly Activates PKM2 and Suppresses Leukemia” Journal of Medicinal Chemistry 2018, 61, 4155−4164.
Purohit, S.; Li, T. -H.; Guan, W. -Y.; Song, X. -Z.; Song, J.; Tian, Y.’ Li, L.; Sharma, A.; Dun, B. -Y.; Mysona, D.; Ghamande, S.’ Rungruang, B.; Cummings, R. D.; Wang, P. G.; She, J. -X. “Multiplex glycan bead array for high throughput and high content analyses of glycan binding proteins” Nature Communications 2018, 9, 258.
Zhang, Q.; Ma, C.; Gearing, M.; Wang, P. G.; Chin, L.-S.; Li, L. “Integrated proteomics and network analysis identifies protein hubs and network alterations in Alzheimer’s disease” Acta Neuropathological Communications2018,6:19.
Wen, L.; Liu, D.; Zheng, Y.; Huang, K.; Cao, X.; Song, J.; Wang, P. G. “A one-step chemoenzymatic labeling Strategy for probing sialylated Thomsen-Friedenreich Antigen” ACS Central Science2018, 4(4),451-457.
Wen, F.; Li, L.; Zhao, N.; Chiang, M. J.; Xie, H.; Cooley, J.; Webby, R.; Wang, P. G.; Wan, X. F. “AY161F Hemagglutinin Substitution Increases Thermostability and Improves Yields of 2009 H1N1 Influenza A Virus in Cells”.Journal of Virology2018, Jan 2;92(2).
Yang, B., Tang, S., Ma, C., Li, S.T., Shao, G.C., Dang, B., DeGrado, W.F., Dong, M.Q., Wang, P.G., Ding, S. and Wang, L. "Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions." Nature Communications 2017, 2240.
Li, S., Wang, S., Fu, X., Liu, X.W., Wang, P. G.and Fang, J. "Sequential one-pot multienzyme synthesis of hyaluronan and its derivative." Carbohydrate Polymers 2017, 221-227.
Aguilar, A. L., Hou, X., Wen, L., Wang, P. G. and Wu, P. "A Chemoenzymatic Histology Method for O- GlcNAc Detection." ChemBioChem 2017, 2416-2421.
Zang, L., Kondengaden, S.M., Zhang, Q., Li, X., Sigalapalli, D.K., Kondengadan, S.M., Huang, K., Li, K.K., Li, S., Xiao, Z. and Wen, L., Wang, P.G. "Structure based design, synthesis and activity studies of small hybrid molecules as HDAC and G9a dual inhibitors."Oncotarget 2017, 63187.
Gashash, E.A., Aloor, A., Li, D., Zhu, H., Xu, X.Q., Xiao, C., Zhang, J., Parameswaran, A., Song, J., Ma, C. and Xiao, W. and Wang, P. G. "An Insight into Glyco-Microheterogeneity of Plasma von Willebrand Factor by Mass Spectrometry." Journal of Proteome Research 2017, 3348-3362.
393. Zhou, J., Liu, Y., Zhu, H., Zhu, H. and Wang, P. G."Synthesis of silodosin glucuronide and its deuterated counterpart: solving a problematic O-glycosylation of a nitrogen-containing molecule." Heterocyclic Communications2017, 187-195.
Jiang, K., Zhu, H., Li, L., Guo, Y., Gashash, E., Ma, C., Li, J., Zhang, L. and Wang, P.G. "Sialic acid linkage-specific permethylation for improved profiling of protein glycosylation by MALDI-TOF MS." Analytica Chimica Acta2017, 981, 53-61.
Wu, Z., Liu, Y., Li, L., Wan, X.F., Zhu, H., Guo, Y., Wei, M., Guan, W. and Wang, P.G. "Decoding glycan protein interactions by a new class of asymmetric N-glycans." Organic & Biomolecular Chemistry 2017, 8946-8951.
Yu, H.; Li, Y.; Wu, Z.; Li, L.; Zeng, J., Zhao; C., Wu, Y.; Tasnima, N.; Wang, J.; Liu, H.; Gadi, M.R.; Wang, P.G.; X, Chen. "H. pylori α1–3/4-fucosyltransferase (Hp3/4FT)-catalyzed one-pot multienzyme (OPME) synthesis of Lewis antigens and human milk fucosides." Chemical Communications 2017, 11012-11015.
Calderon, A.D., Li, L. and Wang, P.G. "FUT8: from biochemistry to synthesis of core-fucosylated N-glycans." Pure and Applied Chemistry 2017, 911-920.
Song, Q.; Wu, Z.; Fan, Y.; Song, W.; Zhang, P.; Wang, L.; Wang, F.; Xu, Y.; Wang, P. G.; Cheng, J. "Production of homogeneous glycoprotein with multisite modifications by an engineered N-glycosyltransferase mutan". Journal of Biological Chemistry2017, 292, 8856.
Ma, J.; Wang, Q.; Huang, Z.; Yang, X.; Nie, Q.; Hao, W.; Wang, P. G.; Wang, X. "Glycosylated platinum (IV) complexes as substrates for glucose transporters (GLUTs) and organic cation transporters (OCTs) exhibited cancer targeting and human serum albumin binding properties for drug delivery". Journal of Medicinal Chemistry 2017.60, 5736.
Jiang, K.; Aloor, A.; Qu, J.; Xiao, C.; Wu, Z.; Ma, C.; Zhang, L.; Wang, P. G. "Rapid and sensitive MALDI MS analysis of oligosaccharides by using 2-hydrazinopyrimidine as a derivative reagent and co-matrix".Analytical and Bioanalytical Chemistry2017, 409, 421.
Zhang, G. -Q.; Jin, H.; Zhao, Y.; Guo, L.; Gao, X.; Wang, X.; Tie, S.; Shen, J.; Wang, P. G.; Gan, H.; Cui, H.; Zhao, W. “An efficient anticoagulant candidate: Characterization, synthesis and in vivo study of a fondaparinux analogue Rrt1.17”. European Journal of Medicinal Chemistry2017, 126, 1039.
Fu, X.; Shang, W.; Wang, S.; Liu, Y.; Qu, J.; Chen, X.; Wang, P. G.; Fang, J. “A general strategy for the synthesis of homogeneous hyaluronan conjugates and their biological applications.” Chemical Communications 2017, 53, 3555.
Ma, J.; Yang, X.; Hao, W.; Huang, Z.; Wang, X.; Wang, P. G.“Mono-functionalized glycosylated platinum(IV) complexes possessed both pH and redox dual-responsive properties: Exhibited enhanced safety and preferentially accumulated in cancer cells in vitro and in vivo”. European Journal of Medicinal Chemistry2017, 128, 45.
Zhu, H.; Li, X.; Qu, J.; Xiao, C.; Jiang, K.; Gashash, E.; Liu, D.; Song, J.; Cheng, J.; Ma, C.; Wang, P. G.“Diethylaminoethyl sepharose (DEAE-sepharose) microcolumn for enrichment of glycopeptides”. Analytical and Bioanalytical Chemistry2017, 409, 511.
Jiang, K.; Zhu, H.; Xiao, C.; Liu, D.; Edmunds, G.; Wen, L.; Ma, C.; Li, J.; Wang, P. G.“Solid-phase reductive amination for glycomic analysis”. Analytica Chimica Acta2017, 962, 32.
Xu, Y.; Wu, Z.; Zhang, P.; Zhu, H.; Zhu, H.; Song, Q.; Wang, L.; Wang, F.; Wang, P. G.; Cheng, J. “A novel enzymatic method for synthesis of glycopeptides carrying natural eukaryotic N-glycans.” Chemical Communications 2017, 53, 9075.
Santra, A.; Li, Y.; Yu, H.; Slack, T. J.; Wang, P. G.; Chen, X. “Highly efficient chemoenzymatic synthesis and facile purification of a-Gal pentasaccharyl ceramide Gala3nLc4bCer.” Chemical Communications2017, 53, 8280.
Liu, Y.; Wang, Y.; Yu, F.; Zhang, Z.; Yang, Z.; Zhang, W.; Wang, P. G.; Zhao, W. “Potentiating the immune response of MUC1-based antitumor vaccines using a peptide-based nanovector as a promising vaccine adjuvant”. Chemical Communications 2017, 53, 9486.
Wu, Z.; Liu, Y.; Ma, C.; Li, L.; Bai, J.; Byrd-Leotis, L.; Lasanajak, Y.; Guo, Y.; Wen, L.; Zhu, H.; Song, J.; Li, Y.; Steinhauer, D. A.; Smith, D. F.; Zhao, B.; Chen, X.; Guan, W.; Wang, P. G.“Identification of the binding roles of terminal and internal glycan epitopes using enzymatically synthesized N-glycans containing tandem epitopes”. Organic and Biomolecular Chemistry2016, 14, 11106.
Kondengaden, S. M.; Luo, L. F.; Huang, K.; Zhu, M.; Zang, L.; Bataba, E.; Wang, R.; Luo, C.; Wang, B.; Li, K. K.; Wang, P. G.“Discovery of novel small molecule inhibitors of lysine methyltransferase G9a and their mechanism in leukemia cell lines”. European Journal of Medicinal Chemistry 2016, 122, 382.
Li, J.; Wang, J.; Wen, L.; Zhu, H.; Li, S.; Huang, K.; Jiang, K.; Li, X.; Ma, C.; Qu, J.; Parameswaran, A.; Song, J.; Zhao, W.; Wang, P. G.“An OGA-resistant probe allows specific visualization and accurate identification of O-GlcNAc-modified proteins in cells”.ACS Chemical Biology 2016, 11, 3002.
Liu, Y.; Wen, L.; Li, L.; Gadi, M. R.; Guan, W.; Huang, K.; Xiao, Z.; Wei, M.; Ma, C.; Zhang, Q.; Yu, H.; Chen, X.; Wang, P. G.;Fang, J. “A general chemoenzymatic strategy for the synthesis of glycosphingolipids”.European Jourrnal of Organic Chemistry 2016, 25, 4315.
Wen, L.; Huang, K.; Zheng, Y.; Liu, Y.; Zhu, H.; Wang, P. G.“A two-step strategy for the preparation of 6-deoxy-l-sorbose.”Bioorganic and Medicinal Chemistry Letters 2016, 26, 4358.
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Shang, W.; Zhai, Y.; Ma, Z.; Yang, G.; Ding, Y.; Han, D.; Li, J.; Zhang, H.; Liu, J.; Wang, P. G.; Liu, X. W.; Chen, M. “Production of human blood group B antigen epitope conjugated protein in Escherichia coliand utilization of the adsorption blood group B antibody”. Microbial Cell Factories2016, 15, 138.
Xiao, Z.; Guo, Y.; Liu, Y.; Li, L.; Zhang, Q.; Wen, L.; Wang, X.; Kondengaden, S. M.; Wu, Z.; Zhou, J.; Cao, X.; Li, X.; Ma, C.; Wang, P. G.“Chemoenzymatic synthesis of a library of human milk oligosaccharides”. Journal of Organic Chemistry2016, 81, 5851.
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Zhang, H.; Wang, B.; Ma, Z.; Wei, M.; Liu, J.; Li, D.; Zhang, H.; Wang, P. G.; Chen, M. “L-rhamnose enhances the immunogenicity of melanoma-associated antigen A3 for stimulating antitumor immune responses”. Bioconjugate Chemistry2016, 27, 1112.
Jiang, K.; Bai, B.; Ta, Y.; Zhang, T.; Xiao, Z.; Wang, P. G.;Zhang, L. “O-GlcNAc regulates NEDD4-1 stability via caspase-mediated pathway”. Biochemical and Biophysical Research Communications2016, 471, 539.
Ma, J.; Wang, Q.; Yang, X.; Hao, W.; Huang, Z.; Zhang, J.; Wang, X.; Wang, P. G.“Glycosylated platinum(IV) prodrugs demonstrated significant therapeutic efficacy in cancer cells and minimized side-effects”. Dalton Transactions2016, 45, 11830.
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Liu, Y.; Zhang, W.; He, Q.; Yu, F.; Song, T.; Liu, T.; Zhang, Z.; Zhou, J.; Wang, P. G.; Zhao, W. “Fully synthetic self-adjuvanting MUC1-fibroblast stimulating lipopeptide 1 conjugates as potential cancer vaccines”. Chemical Communications 2016, 52, 10886.
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Ren, H.; Yang, B.; Ma, C.; Hu, Y. S.; Wang, P. G.; Wang, L. “Cysteine sulfoxidation increases the photostability of red fluorescent proteins”. ACS Chemical Biology2016, 11, 2679.
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Li, X.; Rao, X.; Cai, L.; Liu, X.; Wang, H.; Wu, W.; Zhu, C.; Chen, M.; Wang, P. G.; Yi, W. “Targeting tumor cells by natural anti-carbohydrate antibodies using rhamnose-functionalized liposomes”. ACS Chemical Biology2016, 11, 1205.
Li, L.; Woodward, R. L.; Han, W.; Qu, J.; Song, J.; Ma, C.; Wang, P. G.“Chemoenzymatic synthesis of the bacterial polysaccharide repeating unit undecaprenyl pyrophosphate and its analogs”. Nature Protocol2016, 11, 1280.
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Rao, X.; Duan, X.; Mao, W.; Li, X.; Li, Z.; Li, Q.; Zheng, Z.; Xu, H.; Chen, M.; Wang, P. G.; Wang, Y.; Shen, B.; Yi, W. “O-GlcNAcylation of G6PD promotes the pentose phosphate pathway and tumor growth.” Nature Communications2015, 6, 8468.
Wang, J.; Nie, Y.; Li, Y.; Hou, Y.; Zhao, W.; Deng, J.; Wang, P. G.; Bai, G. “Identification of target proteins of mangiferin in mice with acute lung injury using functionalized magnetic microspheres based on click chemistry.” Journal of Agricultural and Food Chemistry2015, 63, 10013.
Ma, C.; Qu, J.; Meisner, J.; Zhao, X.; Li, X.; Wu, Z.; Zhu, H.; Yu, Z.; Li, L.; Guo, Y.; Song, J.; Wang, P. G. “Convenient and precise strategy for mapping N-glycosylation sites using microwave-assisted acid hydrolysis and characteristic ions recognition.” Anaytical Chemistry2015, 87, 7833.
Li, F.; Li, S.; Liu, X.; Yang, X.; Wang P.;Shen Y. “The structure of WbnH in a near active state.” Protein and Cell2015, 6, 615.
Wang, Q.; Zhang, H.; Ning, X.; Hang, H.; Huang, Z.; Song, H.; Wang, X.; Wang, P. G.“Microwave-assisted construction of C-hydroxydiketopiperazines using Lanthanum(III) triflate.”Asian Journal of Organic Chemistry 2015, 4, 132.
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Wang, W.; Yang, Z.; Xu, Y.; Liu, T.; Song, T.; Zhao, Y.; Xu, X.; Zhao W.; Wang, P. G.“Armed and disarmed” theory in the addition of an azide radical to glucals.” RSC Advances2015, 5, 38577.
Chen, C.; Zhang, Y.; Xue, M.; Liu, X. W.; Li, Y.; Chen, X.; Wang, P. G.;Wang, F.; Cao, H. “Sequential one-pot multienzyme (OPME) synthesis of lacto-N-neotetraose and its sialyl and fucosyl derivatives”. Chemical Communications 2015, 51, 7689.
Li, L.; Liu, Y.; Ma, C.; Qu, J.; Calderon, A. D.; Wu, B.; Wei, N.; Wang, X.; Guo, Y.; Xiao, Z.; Song, J.; Sugiarto, G.; Li, Y.; Yu, H.; Chen, X.; Wang, P. G.“Efficient chemoenzymatic synthesis of an N-glycan iosomer library”. Chemical Science.2015, 6, 5652.
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Li, L.; Liu, Y.; Li, T.; Wang, W.; Yu, Z.; Ma, C.; Qu, J.; Zhao, W.; Chen, X.; Wang, P. G.“Efficient chemoenzymatic synthesis of novel galacto-N-biose derivatives and their sialylated forms”. Chemical Communications 2015, 51, 10310.
Guo, Y.; Fang, J.; Li, T.; Li, X.; Ma, C.; Wang, X.; Wang, P. G.;Li, L. “Comparing substrate specificity of two UDP-sugar pyrophosphorylases and efficient one-pot enzymatic synthesis of UDP-GlcA and UDP-GalA”. Carbohydrate Research2015, 411, 1.
Wu, B.; Wei, N.; Thon, V.; Wei, M.; Yu, Z.; Xu, Y.; Chen, X.; Liu, J.; Wang, P. G.; Li, T. “Facile chemoenzymatic synthesis of biotinylated heparosan hexasaccharide”. Organic and Biomolecular Chemistry2015, 13, 5098.
Shang, W.; Xiao, Z.; Yu, Z.; Wei, N.; Zhao, G.; Zhang, Q.; Wei, M.; Wang, X.; Wang, P. G.; Li, T. “Chemical synthesis of the outer core oligosaccharide of Escherichia coliR3 and immunological evaluation”. Organic and Biomolecular Chemistry2015, 13, 4321.
Muthana, M.; Qu, J.; Xue, M.; Klyuchnik, T.; Siu, A.; Li, Y.; Zhang, L.; Yu, H.; Li, L.; Wang, P. G.; Chen, X. “Improved one-pot multienzyme (OPME) systems for synthesizing UDP-uronic acids and glucuronides”. Chemical Communications 2015, 51, 4595.
Ma, C.; Zhang, Q.; Qu, J.; Zhao, X.; Li, X.; Liu, Y.; Wang, P. G.“A precise approach in large scale core-fucosylated glycoprotein identification with low- and high-normalized collision energy”. Journal of Proteomics2015, 114, 61.
Zhang, H.; Wang, Q.; Ning, X.; Hang, H.; Ma, J.; Yang, X.; Lu, X.; Zhang, J.; Li, Y.; Niu, C.; Song, H.; Wang, X.; Wang, P. G.“Synthesis and biological evaluations of a series of thaxtomin analogues”. Journal of Agricultural and Food Chemistry2015, 63, 3734.
Xing, L.; Wang, X.; Li, H.; Zhou, W.; Kang, N.; Wang, P.; Wang, B. “Metal-free synthesis of methylene-bridged bis-1,3-dicarbonyl compounds via oxidative C-C bond cleavage of tertiary aliphatic amines”.RSC Advances 2014, 4, 26783.
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Li, T.; Ye, H.; Cao, X.; Wang, J.; Liu, Y.; Zhou, L.; Liu, Q.; Wang, W.; Shen, J.; Zhao, W.; Wang P. “Total synthesis of anticoagulant pentasaccharide fondaparinux”. ChemMedChem 2014, 9, 1071.
Xu, Y.; Wang, W.; Cai, Y.; Yang, X.; Wang, P. G.; Zhao, W. “A convenient and efficient synthesis of glycals by zinc nanoparticles”. RSC Advances2014, 4, 46662.
Yan, X.; Zhang, Y.; Zhang, H.; Wang, P. G.; Chu, X.; Wang, X. “Amphiphilic polyethylenimine (PEI) as highly efficient non-viral gene carrier”. Organic and Biomolecular Chemistry2014, 12, 1975.
Viennois, E.; Xiao, B.; Ayyadurai, S.; Wang, L.; Wang, P. G.; Zhang, Q.; Chen, Y.; Merlin, D. “Micheliolide, a new sesquiterpene lactone that inhibits intestinal inflammation and colitis-associated cancer”. Laboratory Investigation2014, 94, 950.
Cheng, C.; Gu, J.; Su, J.; Ding, W.; Yin, J.; Liang, W.; Yu, X.; Ma, J.; Wang, P. G.; Xiao, Z.; Liu, Z. J. “Crystallization, preliminary X-ray crystallographic and cryo-electron microscopy analysis of a bifunctional enzyme fucokinase/L-fucose-1-P-guanylyltransferase from Bacteroides fragilis”. Acta Crystallographica Section F Structural Biology Communications2014, 70, 1206.
Zhao, G.; Wu, B.; Li, L.; Wang, P. G.“O-antigen polymerase adopts a distributive mechanism for lipopolysaccharide biosynthesis”. Applied Microbiology and Biotechnology2014, 98, 4075.
Guo, L.; Liu, T.; Chen, K.; Song, T.; Wang, P. G.; Zhao, W. “Facile synthesis of 5-hydroxy-L-lysine from D-galactose as a chiral-precursor”. Organic and Biomolecular Chemistry2014, 12, 7310.
Li, T.; Wen, L.; Williams, A.; Wu, B.; Li, L.; Qu, J.; Meisner, J.; Xiao, Z.; Fang, J.; Wang, P. G. “Chemoenzymatic synthesis of ADP-D-glycero-b-D-manno-heptose and study of the substrate specificity of HldE”. Bioorganic and Medicinal Chemistry2014, 22, 1139.
Zhao, X.; Zou, Y.; Xue, M.; Ma, Z.; Wang, S.; Wang, P. G.; Chen, M. “A one-pot approach to bio-synthesize globotriose and its derivatives from simpler substrates”. European Journal of Medicinal Chemistry2014, 80, 423.
Ma, Z.; Zhang, H.; Shang, W.; Zhu, F.; Han, W.; Zhao, X.; Han, D.; Wang, P. G.; Chen, M. “Glycoconjugate vaccine containing Escherichia coli O157:H7 O-antigen linked with maltose-binding protein elicits humoral and cellular responses”. PLOS One2014, 9, e105215.
Liu, Y.; Liu, Y.; Jiang, H.; Xu, L.; Cheng, Y.; Wang, P. G.; Wang, F. “Preparation, antiangiogenic and antitumoral activities of the chemically sulfated glucan from Phellinus ribis.” Carbohydrate Polymers2014, 106, 42.
Li, H.-Y.;Xing, L.-J.; Xu, T.; Wang, P.; Liu R.-H.; Wang, B. “An addition of benzylic sp3 C-H to electron-deficient olefins.” Tetrahedron Letters 2013, 54, 858.
Zhang, H.; Ning, X.; Hang, H.; Ru, X.; Li, H.; Li, Y.; Wang, L.; Zhang, X.; Yu, S.; Qiao, Y.; Wang, X.; Wang, P. G.“Total synthesis of thaxtomin A and its stereoisomers and findings of their biological activities.” Organic Letters2013, 15, 5670.
Zhou, F.; Yan, H.; Li, L.; Liu, X.; Wang, Y.; Wang, P.; Zhang, L. “FBXW10 is negatively regulated in transcription and expression level by protein O-GlcNAcylation.” Biochemical and Biophysical Research Communications2013, 438, 427.
Ma, X.; Liu, P.; Yan, H.; Sun, H.; Liu, X.; Zhou, F.; Li, L.; Chen, Y.; Muthana, M. M.; Chen, X.; Wang, P. G.; Zhang, L. “Substrate specificity provides insights into the sugar donor recognition mechanism of O-GlcNAc transferase (OGT)”. PLOS One2013, 8, e63452.
Guo, L.; Liu, Y.; Wan, Y.; Wang, P. G.; Zhao, W. “Effective and one-step stereo-controlled synthesis of benzyloxylated-diiodopentanes for the synthesis of five-membered imino-sugars.”Tetrahedron Letters 2013, 54, 2579.
Li, M.; Liu, X.; Sun, X.; Wang, Z.; Guo, W.; Hu, F.; Yao, H.; Cao, X.; Jin, J.; Wang, P. G.; Shen, J.; Li, Z. “Therapeutic effects of NK-HDAC-1, a novel histone deacetylase inhibitor, on collagen-induced arthritis through the induction of apoptosis of fibroblast-like synoviocytes.” Inflammation2013, 36, 888.
Zhao, Q.; Zhang, J.; Song, L.; Ji, Q.; Yao, Y.; Cui, Y.; Shen, J.; Wang, P. G.; Kong, D. “Polysaccharide-based biomaterials with on-demand nitric oxide releasing property regulated by enzyme catalysis.” Biomaterials2013, 34, 8450.
Xie, C.; Han, W.; Wang, P. G.; Cheng, J. “Probing the role of highly conserved residues forming the acceptor binding pocket of the promiscuous glycosyltransferase MGT in defining the specificity towards a panel of flavonoids”. Biochemistry (Moscow)2013, 78, 536.
Wang, Y.; Wang, P. G.“Polysaccharide-based systems in drug and gene delivery”. Advanced Drug Delivery Reviews2013, 65, 1121.
Liu, J.; Zou, Y.; Guan, W.; Zhai, Y.; Xue, M.; Jin, L.; Zhao, X.; Dong, J.; Wang, W.; Shen, J.; Wang, P. G.; Chen, M. “Biosynthesis of nucleotide sugars by a promiscuous UDP-sugar pyrophosphorylase from Arabidopsis thaliana (AtUSP).” Bioorganic and Medicinal Chemistry Letters2013, 23, 3764.
Li, Z. H.; Zhang, X. B.; Han, X. Q.; Feng, C. R.; Wang, F. S.; Wang, P. G.;Shen, J.; Shi, Y. K. “Antitumor effects of a novel histone deacetylase inhibitor NK-HDAC-1 on breast cancer.” Oncology Reports2013, 30, 499.
Zou, Y.; Xue, M.; Wang, W.; Cai, L.; Chen, L.; Liu, J.; Wang, P. G.; Shen, J.; Chen, M. “One-pot three-enzyme synthesis of UDP-Glc, UDP-Gal, and their derivatives.” Carbohydrate Research2013, 373, 76.
Wang, L.; Han, W.; Xie, C.; Hou, J.; Fang, Q.; Gu, J.; Wang, P. G.; Cheng, J. “Comparing the acceptor promiscuity of a Rosa hybrida glucosyltransferase RhGT1 and an engineered microbial glucosyltransferase OleD(PSA) toward a small flavonoid library.” Carbohydrate Research2013, 368, 73.
Li, L.; Liu, Y.; Wan, Y.; Li, Y.; Chen, X.; Zhao, W.; Wang, P. G.“Efficient enzymatic synthesis of guanosine 5'-diphosphate-sugars and derivatives.” Organic Letters2013, 15, 5528.
Wu, B.; Woodward, R.; Wen, L.; Wang, X.; Zhao, G.; Wang, P. G.“Synthesis of a comprehensive polyprenol library for evaluation of bacterial enzyme lipid substrate specificity.” European Journal of Organic Chemistry2013, 2013, 8162.
Li, Z.; Li, T.; Dai, S.; Xie, X.; Ma, X.; Zhao, W.; Zhang, W.; Li, J.; Wang, P. G.“New insights into the pharmacological chaperone activity of c2-substituted glucoimidazoles for the treatment of Gaucher disease.” Chembiochem2013, 14, 1239.
Ye, H.; Liu, R.; Li, D.; Liu, Y.; Yuan, H.; Guo, W.; Zhou, L.; Cao, X.; Tian, H.; Shen, J.; Wang, P. G.“A safe and facile route to imidazole-1-sulfonyl azide as a diazotransfer reagent.” Organic Letters2013, 15, 18.
Fang, J.; Xue, M.; Gu, G.; Liu, X. W.; Wang, P. G.“A chemoenzymatic route to synthesize unnatural sugar nucleotides using a novel N-acetylglucosamine-1-phosphate pyrophosphorylase from Camphylobacter jejuni NCTC 11168.” Bioorganic and Medicinal Chemistry Letters2013, 23, 4303.
Musumeci, M. A.; Hug, I.; Scott, N. E.; Ielmini, M. V.; Foster, L. J.; Wang, P. G.; Feldman, M. F. “In vitro activity of Neisseria meningitidisPglL O-oligosaccharyltransferase with diverse synthetic lipid donors and a UDP-activated sugar”. Journal of Biological Chemistry2013, 288, 10578.
Li, L.; Liu, Y.; Wang, W.; Cheng, J.; Zhao, W.; Wang, P.“A highly efficient galactokinase from Bifidobacterium infantis with broad substrate specificity.” Carbohydrate Research2012, 355, 35.
Han, W.; Cai, L.; Wu, B.; Li, L.; Xiao, Z.; Cheng, J.; Wang, P. G.“The wciN gene encodes an alpha-1,3-galactosyltransferase involved in the biosynthesis of the capsule repeating unit of Streptococcus pneumoniae serotype 6B.” Biochemistry2012, 51, 5804.
Li, T.; Li, Z.; Li, J.; Wang, J.; Guo, L.; Wang, P. G.;Zhao, W. “Elevation of cellular O-GlcNAcylation level by a potent and selective O-GlcNAcase inhibitor based on tetrahydroimidazopyridine scaffold.” Bioorganic and Medicinal Chemistry Letters2012, 22, 6854.
Ren, G.; Hou, J.; Fang, Q.; Sun, H.; Liu, X.; Zhang, L.; Wang, P. G.“Synthesis of flavonol 3-O-glycoside by UGT78D1.” Glycoconjugate Journal2012, 29, 425.
Ban, L.; Pettit, N.; Li, L.; Stuparu, A. D.; Cai, L.; Chen, W.; Guan, W.; Han, W.; Wang, P. G.; Mrksich, M. “Discovery of glycosyltransferases using carbohydrate arrays and mass spectrometry.” Nature Chemical Biology2012, 8, 769.
Xue, M.; Guan, W.; Zou, Y.; Fang, J.; Liu, X. W.; Wang, P. G.; Wang, F. “Investigation of the nucleotide triphosphate substrate specificity of homo sapiens UDP-N-acetylgalactosamine pyrophosphorylase (AGX1).” Bioorganic and Medicinal Chemistry Letters2012, 22, 3957.
Zhai, Y.; Liang, M.; Fang, J.; Wang, X.; Guan, W.; Liu, X.-W.; Wang, P.; Wang, F. “NahK/GlmU fusion enzyme: Characterization and one-step enzymatic synthesis of UDP-N-acetylglucosamine”. Biotechnology Letters2012, 34, 1321.
Zhang, Y.; Zhou, C.; Kwak, K. J.; Wang, X.; Yung, B.; Lee, L. J.; Wang, Y.; Wang, P. G.; Lee, R. J. “Efficient siRNA delivery using a polyamidoamine dendrimer with a modified pentaerythritol core.” Pharmaceutical Research2012, 29, 1627.
Hou, J.; Li, Z.; Fang, Q.; Feng, C.; Zhang, H.; Guo, W.; Wang, H.; Gu, G.; Tian, Y.; Liu, P.; Liu, R.; Lin, J.; Shi, Y. K.; Yin, Z.; Shen, J.; Wang, P. G. “Discovery and extensive in vitro evaluations of NK-HDAC-1: A chiral histone deacetylase inhibitor as a promising lead.” Journal of Medicinal Chemistry2012, 55, 3066.
Li, L.-T.; Zhou, L.-F.; Li, Y.-J.; Huang, J.; Liu, R.-H.; Wang, B.; Wang, P.“Facile synthesis of 1,2,3-triazole analogues of SGLT2 inhibitors by “click chemistry””.Bioorganic and Medicinal Chemistry Letters 2012, 22, 642.
Styslinger, T. J.; Zhang, N.; Bhatt, V. S.; Pettit, N.; Palmer, A. F.; Wang, P. G.“Site-selective glycosylation of hemoglobin with variable molecular weight oligosaccharides: potential alternative to PEGylation.”Journal of American Chemical Society 2012, 134, 7507.
Gu, G.; Wang, H.; Liu, P.; Fu, C.; Li, Z.; Cao, X.; Li, Y.; Fang, Q.; Xu, F.; Shen, J.; Wang, P. G. “Discovery and structural insight of a highly selective protein kinase inhibitor hit through click chemistry.” Chemical Communications 2012, 48, 2788.
Zhang, Z.-X.; Wu, B.; Wang, B.; Li, T.-H.; Zhang, P.-F.; Guo, L.-N.; Wang, W.-j.; Zhao, W.; Wang, P. G. “Facile and stereo-controlled synthesis of 2-deoxynojirimycin, Miglustat and Miglitol”. Tetrahedron Letters 2011, 52, 3802.
Zhang, Z.; Zhao, W.; Wang, B.; Xia, C.; Zhang, W.; Wang, P. G.“The total synthesis of immunostimulant a-galactosylceramides from naturally configured a-galactoside raffinose.” Organic Letters2011, 13, 4530.
Wang, W.; Li, L.; Jin, C.; Niu, Y.; Li, S.; Ma, J.; Li, L.; Liu, Y.; Cai, L.; Zhao, W.; Wang, P. G.“Enzymatic synthesis of a 6-sialyl lactose analogue using a pH-responsive water-soluble polymer support.” Bioorganic and Medicinal Chemistry Letters2011, 21, 5041.
Wang, W.; Jin, C.; Guo, L.; Liu, Y.; Wan, Y.; Wang, X.; Li, L.; Zhao, W.; Wang, P. G.“Preparation of oligosaccharides by homogenous enzymatic synthesis and solid phase extraction.” Chemical Communications2011, 47, 11240.
Li, T.; Guo, L.; Zhang, Y.; Wang, J.; Zhang, Z.; Li, J.; Zhang, W.; Lin, J.; Zhao, W.; Wang, P. G.“Structure-activity relationships in a series of C2-substituted gluco-configured tetrahydroimidazopyridines as b-glucosidase inhibitors.” Bioorganic and Medicinal Chemistry2011, 19, 2136.
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Zhou, Z.; Zhang, C.; Xia, C.; Chen, W.; Zhu, H.; Shang, P.; Ma, F.; Wang, P. G.; Zhang, J.; Xu, W.; Tian, Z. “Enhanced antitumor effects by chemical modified IGb3 analogues.” Molecular Cancer Therapies2011, 10, 1375.
Li, Y.; Yu, H.; Chen, Y.; Lau, K.; Cai, L.; Cao, H.; Tiwari, V. K.; Qu, J.; Thon, V.; Wang, P. G.; Chen, X. “Substrate promiscuity of N-acetylhexosamine 1-kinases.” Molecules2011, 16, 6396.
Wang, W.; Jin, C.; Guo, L.; Liu, Y.; Wan, Y.; Wang, X.; Li, L.; Zhao, W.; Wang, P. G.“Preparation of oligosaccharides by homogenous enzymatic synthesis and solid phase extraction.” Chemical Communications 2011, 47, 11240.
Li, Z.; Cai, L.; Qi, Q.; Styslinger, T. J.; Zhao, G.; Wang, P. G.“Synthesis of rare sugars with L-fuculose-1-phosphate aldolase (FucA) from thermus thermophilus HB8.” Bioorganic and Medicinal Chemistry Letters2011, 21, 5084.
Guan, W.; Ban, L.; Cai, L.; Li, L.; Chen, W.; Liu, X.; Mrksich, M.; Wang, P. G.“Combining carbochips and mass spectrometry to study the donor specificity for the Neisseria meningitidis b1,3-N-acetylglucosaminyltransferase LgtA.” Bioorganic and Medicinal Chemistry Letters 2011, 21, 5025.
Cai, L.; Ban, L.; Guan, W.; Mrksich, M.; Wang, P. G.“Enzymatic synthesis and properties of uridine-5'-O-(2-thiodiphospho)-N-acetylglucosamine.” Carbohydrate Research 2011, 346, 1576.
Li, Z.; Cai, L.; Qi, Q.; Wang, P. G.“Enzymatic synthesis of D-sorbose and D-psicose with aldolase RhaD: Effect of acceptor configuration on enzyme stereoselectivity.” Bioorganic and Medicinal Chemistry Letters2011, 21, 7081.
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Cheng, H.; Cao, X.; Xian, M.; Fang, L.; Cai, T. B.; Ji, J. J.; Tunac, J. B.; Sun, D.; Wang, P. G.“Synthesis and enzyme-specific activation of carbohydrate-geldanamycin conjugates with potent anticancer activity”. Journal of Medicinal Chemistry2005, 48, 645.
Zhang, G.; Shen, J.; Cheng, H.; Zhu, L.; Fang, L.; Luo, S.; Muller, M. T.; Lee, G. E.; Wei, L.; Du, Y.; Sun, D. Wang, P. G.“Syntheses and biological activities of rebeccamycin analogs with uncommon sugars”. Journal of Medicinal Chemistry2005, 48, 2600.
Zhang, G.; Fang, L.; Zhu, L.; Aimiuwu, J. E.; Shen, J.; Cheng, H.; Muller, M. T.; Lee, G. E.; Sun, D.; Wang, P. G.“Syntheses and biological activities of disaccharide daunorubicins”. Journal of Medicinal Chemistry2005, 48, 5269.
Zhu, L.; Cao, X.; Chen, W.; Zhang, G.; Sun, D.; Wang, P. G.“Syntheses and biological activities of daunorubicin analogs with uncommon sugars”. Bioorganic and Medicinal Chemistry 2005,13, 6381.
Cai, T. B.; Lu, D.; Tang, X.; Zhang, Y.; Landerholm, M.; Wang, P. G.“New glycosidase activated nitric Oxide donors: Glycose and 3-morphorlinosydnonimine conjugates”. Journal of Organic Chemistry 2005,70, 3518.
Cai, T. B.; Lu, D.; Wang, P. G.“N-hydroxyguanidines as substrates of nitric oxide synthases”. Current Topics in Medicinal Chemistry 2005,5, 721.
Guo, H.; Yi, W.; Shao, J.; Lu, Y.; Zhang, W.; Song, J. K.; Wang, P. G.“Molecular analysis of the O-antigen gene cluster of Escherichia coli O86:B7 and characterization of the chain length determinant gene (wzz)”. Applied and Environmental Microbiology 2005,71, 7995.
Chen, M.; Liu, X.; Wang, Z.; Song, J. K.; Qi, Q.; Wang, P. G.“Modification of plant N-glycans processing: The future of producing therapeutic protein by transgenic plants”. Medicinal Research Reviews 2005,25, 343.
Eguchi, H.; Ikeda, Y.; Ookawara, T.; Koyota, S.; Fujiwara, N.; Honke, K.; Wang, P. G.; Taniguchi, N.; Suzuki, K. “Modification of oligosaccharides by reactive oxygen species decreases sialyl lewis x-mediated cell adhesion”. Glycobiology2005, 15, 1094.
Yi, W.; Shao, J.; Zhu, L.; Li, M.; Singh, M.; Lu, Y.; Lin, S.; Li, H.; Ryu, K.; Shen, J.; Guo, H.; Yao, Q.; Bush, C. A.; Wang, P. G.“Escherichia coli O86 O-antigen biosynthetic gene cluster and stepwise enzymatic synthesis of human blood group B antigen tetrasaccharide”. Journal of American Chemical Society2005, 127, 2040.
Li, H.; Zhang, H.; Yi, W.; Shao, J.; Wang, P. G.“Enzymatic synthesis of complex bacterial carbohydrate polymers”. ACS Symposium Series2005, 900, (Polymer Biocatalysis and Biomaterials), 192.
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Zhu, L.; Talukdar, A.; Zhang, G.; Kedenburg, J. P.; Wang, P. G.“A divergent synthesis of uncommon sugars from furanaldehyde”. Synlett2005, (10), 1547.
Cai, T. B.; Lu, D.; Landerholm, M.; Wang, P. G.“Sialated diazeniumdiolate: A new sialidase-activated nitric oxide donor”. Organic Letters2004, 6, 4203.
Cai, T. B.; Wang, P. G.“Recent developments in anticancer nitric oxide donors”. Expert Opinion on Therapeutic Patents2004, 14, 849.
Nahalka, J.; Wu, B.; Shao, J.; Gemeiner, P.; Wang, P. G. “Production of cytidine 5'-monophospho-N-acetyl-β-D-neuraminic acid (CMP-sialic acid) using enzymes or whole cells entrapped in calcium pectate-silica-gel beads”. Biotechnology and Applied Biochemistry2004, 40, 101.
Sanzhong L., Wang, P. G., Cheng, J.-P. " Remarkable rate acceleration of imidazole-promoted Baylis−Hillman reaction involving cyclic enones in basic water solution "Journal of Organic Chemistry2004, 69, 555.
Xian, M.; Fatima, Z.; Zhang, W.; Fang, J.; Li, H.; Pei, D.; Loo, J.; Stevenson, T.; Wang, P. G.“Identification of α-galactosyl epitope mimetics through rapid generation and screening of C-linked glycopeptide library”. Journal of Combinatorial Chemistry 2004,6, 126.
Andreana, P. R.; Kowal, P.; Janczuk, A. J.; Wang, P. G.“α-Galactosyl trisaccharide epitope: Modification of the 6-primary positions and recognition by human anti-α-Gal antibody”. Glycoconjugate Journal 2004,20, 107.
Andreana, P. R.; Xie, W.; Wang, P. G.“Synthesis and modifications of carbohydrates through biotechnology”. ACS Symposium Series., 840(Biocatalysis in Polymer Science), Edited by: Gross R. and Cheng H. N. 2003, 188.
Tang, X.; Cai, T. B.; Wang, P. G.“Synthesis of β-lactamase activated nitric oxide donors”. Bioorganic and Medicinal Chemistry Letters 2003,13, 1687.
Cai, T. B.; Tang, X.; Nagorski, J.; Brauschweiger, P. G.; Wang, P. G.“Synthesis and cytotoxicity of 5-fluorouracil/diazeniumdiolate conjugates”. Bioorganic and Medicinal Chemistry 2003,11, 4971.
Zhang, J. B.; Kowal, P.; Chen, X.; Wang, P. G.“Large-scale synthesis of carbohydrate through biotechnology: production of globotriose derivatives by “superbug’”. Organic and Biomolecular Chemistry2003, 1, 3048
Nahalka, J.; Liu, Z.; Chen, X.; Wang, P. G.“Superbeads: Immobilization in "sweet" chemistry”. Chemistry- A European Journal2003, 9, 372.
Zhang, Y.; Telyatnikov, V.; Sathe, M.; Zeng, X.; Wang, P. G.“Studying the interaction of α-Gal carbohydrate antigen and proteins by quartz-crystal microbalance”. Journal of American Chemistry Society2003, 125, 9292.
Yang, J.; Fu, X.; Jia, Q.; Shen, J.; Biggins, J. B.; Jiang, J.; Zhao, J.; Schmidt, J. J.; Wang, P. G.; Thorson, J. S. “Studies on the substrate specificity of Escherichia coli galactokinase”. Organic Letters2003, 5,2223.
Shao, J.; Li, M.; Jia, Q.; Lu, Y.; Wang, P. G.“Sequence of Escherichia coli O128 antigen biosynthesis cluster and functional identification of an α-1,2-fucosyltransferase”. FEBS Letters2003, 553, 99.
Shao, J.; Hayashi, T.; Wang, P. G.“Enhanced production of α-Gal epitope by metabolically engineered Pichia Pastoris”. Applied and Environmental Microbiology2003, 69, 5238.
Song, J. K.; Zhang, H.; Wu, B.; Zhang, Y.; Li, H.; Xiao, M.; Wang, P. G.“Reassembled biosynthetic pathway for a large-scale synthesis of CMP-Neu5Ac”. Marine Drugs2003, 1, 34.
Zhang, B.; Zhu, X.-Q.; Lu, J.-Y.; He, J.; Wang, P. G.; Cheng, J.-P. “Polysiloxane-supported NAD(P)H model 1-benzyl-1,4-dihydronicotinamide: Synthesis and application in the reduction of activated olefins”. Journal of Organic Chemistry2003, 68, 3295.
Liu, Z.; Lu, Y.; Zhang, J.; Pardee, K.; Wang, P. G.“P1 trisaccharide (Gal-α-1,4-Gal-β-1,4-GlcNAc) synthesis by enzyme glycosylation reactions using recombinant Escherichia coli”. Applied and Environmental Microbiology 2003,69, 2110.
Jia, Q.; Cai, T. B.; Huang, M.; Li, H.; Xian, M.; Poulos, T. L.; Wang, P. G.“Isoform-selective substrates of nitric oxide synthase”. Journal of Medicinal Chemistry 2003,46, 2271.
Chen, X.; Wu, B.; Wang, P. G.“Glucuronides in anti-cancer therapy”. Current Medicinal Chemistry: Anti-Cancer Agents 2003,3, 139.
Shao, J.; Li, M.; Jia, Q.; Wen, Y.; Wang, P. G.“Genetic basis of E. coli O128 polysaccharide biosynthesis gene cluster”. Polymer Preprints (American Chemical Society., Div. Polym. Chem.)2003, 44, 562.
Wang, J.; Zhang, B.; Fang, J.; Sujino, K.; Li, H.; Otter, A.; Hindsgaul, O.; Palcic, M. M.; Wang, P. G.“Frontal affinity chromatography coupled to mass spectrometry: An effective method for Kddetermination and screening of α-Gal derivatives binding to anti-Gal antibodies (IgG)”. Journal Carbohydrate Chemistry 2003, 22, 347.
Shao, J.; Zhang, J.; Kowal, P.; Lu, Y.; Wang, P. G.“Efficient synthesis of globoside and isogloboside tetrasaccharides by using β-1-3-N-acetylgalactosaminyltransferase/UDP-N-acetylglucosamine C4 epimerase fusion protein”. Chemical Communications 2003, 12, 1422.
Peng, Y.-Y.; Ding, Q.-P.; Lia, Z.; Wang, P. G.; Cheng, J.-P. " Proline catalyzed aldol reactions in aqueous micelles: an environmentally friendly reaction system " Tetrahedron Letters2003, 44, 3871.
Zhang, J.; Wu, B.; Zhang, Y.; Kowal, P.; Wang, P. G.“Creatine phosphate-creatine kinase in enzymatic synthesis of glycoconjugates”. Organic Letters 2003,5, 2583.
Li, H.; Shimizu, H.; Flinspach, M.; Jamal, J.; Yang, W. P.; Xian, M.; Cai, T. B.; Wen, E. Z.; Jia, Q.; Wang, P. G.; Poulos, T. L. “The novel binding mode of N-alkyl-N'-hydroxyguanidine to neuronal nitric oxide synthase reveals insights into NO biosynthesis”. Biochemistry2002, 41, 13868.
Jia, Q.; Xie, W.; Zhang, W.; Janczuk, A.; Luo, S.; Zhang, B.; Cheng, J.- P.; Ksebati, M. B.; Wang, P. G.“Ytterbium(III) triflate-catalyzed electrophilic cyclization of glyoxalate-derived unsaturated imines”. Tetrahedron Lett. 2002,43, 2339.
Janczuk, A.; Zhang, W.; Xie, W.; Lou, S.; Cheng, J.-P.; Wang, P. G.“Ytterbium triflate catalyzed electrophilic substitution of indoles: the synthesis of unnatural tryptophan derivatives”. Tetrahedron Letters 2002,43, 4271.
Janczuk, A.; Zhang, W.; Andreana, P. R.; Warrick, J.; Wang, P. G.“The synthesis of deoxy-α-Gal epitope derivatives for the evaluation of an anti-α-Gal antibody binding”. Carbohydrate Research 2002,337, 1247.
Andreana, P. R.; McLellan, J. S.; Chen, Y.; Wang, P. G.“Synthesis of 2,6-dideoxy sugars via ring-closing olefinic metathesis”. Organic Letters 2002,4, 3875.
Wu, X.; Tang, X.; Xian, M.; Brauschweiger, P. G.; Wang, P. G.“Synthesis and cytotoxicities of mannose conjugated S-Nitroso-N-acetylpenicillamine (SNAP)”. Bioorganic and Medicinal Chemistry 2002,10, 2303.
Chen, X.; Liu, Z.; Zhang, J.; Zhang, W.; Kowal, P.; Wang, P. G.“Reassembled biosynthetic pathway for large-scale carbohydrate synthesis: α-gal epitope producing "superbug"”. ChemBioChem 2002,3, 47.
Shao, J.; Zhang, J.; Kowal, P.; Lu, Y.; Wang, P. G.“Overexpression and biochemical characterization of β-1,3-N-acetylgalactosaminyltransferase LgtD from Haemophilus influenzae strain Rd”. Biochemical and Biophysical Research Communications2002, 295, 1.
Nahalka, J.; Liu, Z.; Gemeiner, P.; Wang, P. G.“Nucleoside triphosphates production using recombinant Escherichia colientrapped in calcium pectate gel”. Biotechnology Letters 2002, 24), 925.
Xian, M.; Fujiwara, N.; Wen, Z.; Cai, T. B.; Kazuma, S.; Janczuk, A. J.; Tang, X.; Telyatnikov, V. V.; Zhang, Y.; Chen, X.; Miyamoto, Y.; Taniguchi, N.; Wang, P. G.“Novel substrates for nitric oxide synthases” Bioorganic and Medicinal Chemistry 2002,10, 3049.
Jia, Q.; Janczuk, A. J.; Cai, T. B.; Xian, M.; Wen, Z.; Wang, P. G.“NO donors with anticancer activity”. Expert Opinions on Therapeutic Patents2002, 12, 819.
Wang, P. G.; Xian, M.; Tang, X.; Wu, X.; Wen, Z.; Cai, T. B.; Janczuk, A. J. “Nitric oxide donors: Chemical activities and biological applications”. Chemical Review 2002,102, 1091.
Kowal, P.; Wang, P. G.“New UDP-GlcNAc C4 epimerase involved in the biosynthesis of 2-acetamino-2-deoxy-L-altruronic acid in the O-antigen repeating units of Plesiomonas shigelloides O17”. Biochemistry 2002,41, 15410.
Andreana, P. R.; Xie, W.; Cheng, H. N.; Qiao, L.; Murphy, D. J.; Gu, Q.-M.; Wang, P. G.“In situ preparation of β-D-1-O-hydroxylamino carbohydrate polymers mediated by galactose oxidase”. Organic Letters 2002,4, 1863.
Banerjee, A.; Wang, R.; Supernavage, S. L.; Ghosh, S. K.; Parker, J.; Ganesh, N. F.; Wang, P. G.; Gulati, S.; Rice, P. A. “Implications of phase variation of a gene (pgtA) encoding a pilin galactosyl transferase in gonococcal pathogenesis”. J. Experimental Medicine 2002,196, 147.
Chen, Y.; Janczuk, A.; Chen, X.; Wang, J.; Ksebati, M.; Wang, P. G.“Expeditious syntheses of two carbohydrate-linked cisplatin analogs”. Carbohydrate Research 2002,337, 1043.
Akhter, S.; Vignini, A.; Wen, Z.; English, A.; Wang, P. G.; Mutus, B. “Evidence for S-nitrosothiol-dependent changes in fibrinogen that do not involve transnitrosation or thiolation”. Proceedings of the National Academy of Sciences2002,99, 9172.
Cai, T. B.; Xian, M.; Wang, P. G.“Electrochemical and peroxidase oxidation study of N`-hydroxyguanidine derivatives as NO donors”. Bioorganic and Medicinal Chemistry Letters 2002,12, 1507.
Shao, J.; Zhang, J.; Kowal, P.; Wang, P. G.“Donor substrate regeneration for efficient synthesis of globotetraose and isoglobotetraose”. Applied and Environmental Microbiology 2002,68, 5634.
Liu, Z.; Zhang, J.; Chen, X.; Wang, P. G.“Combined biosynthetic pathway for de novo production of UDP-galactose: catalysis with multiple enzymes immobilized on agarose beads”. ChemBioChem 2002,3, 348.
Andreana, P. R.; Sanders, T.; Janczuk, A.; Warrick, J. I.; Wang, P. G.“Chemo-enzymatic synthesis of polyhydroxyazepanes”. Tetrahedron Letters 2002,43, 6525.
Shao, J.; Zhang, J.; Nahalka, J.; Wang, P. G.“Biocatalytic synthesis of uridine 5`-diphosphate N-acetylglucosamine by multiple enzymes co-immobilized on agarose beads”. Chemical Communications (Cambridge, UK) 2002, 21, 2586.
Wu, B.; Zhang, Y.; Zheng, R.; Guo, C.; Wang, P. G.“Bifunctional phosphomannose isomerase/GDP-D-mannose pyrophosphorylase is the point of control for GDP-D-mannose biosynthesis in Helicobacter pylori”. FEBS Letters 2002,519, 87.
Zhang, J.; Kowal, P.; Fang, J.; Andreana, P.; Wang, P. G.“Efficient chemoenzymatic synthesis of globotriose and its derivatives with a recombinant α-1,4-galactosyltransferase”. Carbohydrate Research2002, 337, 969.
Kowal, P.; Chen, X.; Wang, P. G.“Microbial glycosyltransferases”. In Glycochemistry: Principles, Synthesis, and Applications.Edited by P. G. Wang, and C. Bertozzi, Marcel Dekker, Inc. New York, 2001, 625.
Chen, X.; Zhang, J.; Kowal, P.; Liu, Z.; Andreana, P.; Lu, Y.; Wang, P. G.“Transferring a biosynthetic cycle into a productive Escherichia colistrain: Large-scale synthesis of galactosides”. Journal of American Chemical Society 2001, 123, 8866.
Hou, Y.; Wu, X.; Xie, W.; Braunschweiger, P. G.; Wang, P. G.“The synthesis and cytotoxicity of fructose-1-SNAP, a novel fructose conjugated S-nitroso nitric oxide donor”. Tetrahedron Letters 2001,42, 825.
Tang, X.; Xian, M.; Trikha, M.; Honn, K. V.; Wang, P. G.“Synthesis of peptide-diazeniumdiolate conjugates: towards enzyme activated antitumor agents”. Tetrahedron Letters 2001,42, 2625.
Chen, X.; Fang, J.; Zhang, J.; Liu, Z.; Shao, J.; Kowal, P.; Andreana, P.; Wang, P. G.“Sugar nucleotide regeneration beads (superbeads): A Versatile tool for the practical synthesis of oligosaccharides”. Journal of American Chemical Society 2001,123, 2081.
Zhang, Y.; Wang, P. G.; Brew, K. “Specificity and mechanism of metal ion activation in UDP-galactose: β-Galactoside-α-1,3-galactosyltransferase”. Journal of Biological Chemistry 2001,276, 11567.
Luo, S.; Zhang, B.; Xian, M.; Janczuk, A.; Xie, W.; Cheng, J.-P.; Wang, P. G.“Recent progress in lanthanide-catalyzed organic reactions in protic media”. Chinese Science Bulletin 2001,46, 1673.
Lue, J.-M.; Wittbrodt, J. M.; Wang, K.; Wen, Z.; Schlegel, H. B.; Wang, P. G.; Cheng, J.-P. “NO Affinities of S-nitrosothiols: A direct experimental and computational investigation of RS-NO bond dissociation energies”. Journal of American Chemical Society 2001,123, 2903.
Guo, Z.; Xian, M.; Zhang, W.; McGill, A.; Wang, P. G.“N-Nitrosoanilines: a new class of caspase-3 inhibitors”. Bioorganic and Medicinal Chemistry 2001,9, 99.
Xian, M.; Li, X.; Tang, X.; Chen, X.; Zheng, Z.; Galligan, J. J.; Kreulen, D. L.; Wang, P. G.“N-Hydroxyl derivatives of guanidine-based drugs as enzymatic NO donors”. Bioorganic and Medicinal Chemistry Letters 2001,11, 2377.
Zhang, J.; Wu, B.; Liu, Z.; Kowal, P.; Chen, X.; Shao, J.; Wang, P. G.“Large-scale synthesis of carbohydrates for pharmaceutical development”. Current Organic Chemistry 2001,5, 1169.
Wu, B.; Zhang, Y.; Wang, P. G.“Identification and characterization of GDP-D-mannose 4,6-dehydratase and GDP-L-fucose Synthetase in a GDP-L-fucose biosynthetic gene cluster fromHelicobacter pylori”. Biochemical and Biophysical Research Communications 2001, 285, 364.
Wu, X.; Tang, X.; Xian, M.; Wang, P. G.“Glycosylated diazeniumdiolates: a novel class of enzyme-activated nitric oxide donors”. Tetrahedron Letters 2001,42, 3779.
Chen, X.; Wen, Z.; Xian, M.; Wang, K.; Ramachandran, N.; Tang, X.; Schlegel, H. B.; Mutus, B.; Wang, P. G.“Fluorophore-labeled S-nitrosothiols”. Journal of Organic Chemistry 2001,66, 6064.
Chen, Y.; Wang, P. G.“Facile oxidative cleavage of benzylidene acetals using molecular oxygen catalyzed by N-hydroxyphthalimide/Co(OAc)2”. Tetrahedron Letters 2001,42, 4955.
Chen, Y.; Zhang, W.; Chen, X.; Wang, J.; Wang, P. G.“α-Gal-conjugated anti-rhinovirus agents: chemo-enzymatic syntheses and testing of anti-Gal binding”. Journal of the Chemical Society, Perkin Transactions 1 2001, 14, 1716.
Shetterly, S.; Tom, I.; Yen, T.-Y.; Joshi, R.; Lee, L.; Wang, P. G.; Macher, B. A. “α-1,3-Galactosyltransferase: new sequences and characterization of conserved cysteine residues”. Glycobiology 2001,11, 645.
Andreana, P. R.; Zhang, W.; Wang, P. G.“From a carbohydrate sequence to extensive research programs, the α-Gal epitope as a case study”. In Glycochemistry: Principles, synthesis, and applications.Edited by P. G. Wang, and C. Bertozzi Marcel Dekker, Inc. New York, 2001, 581.
Wang, K.; Wen, Z.; Zhang, W.; Xian, M.; Cheng, J.-P.; Wang, P. G.“Equilibrium and kinetic studies of transnitrosation between S-nitrosothiols and thiols”. Bioorganic and Medicinal Chemistry Letters2001, 11, 433.
Fang, J.; Chen, X.; Zhang, W.; Janczuk, A.; Wang, P. G.“Synthesis of α-Gal epitope analogs with a galaycosyltranferase-epimerase fusion enzyme”. Carbohydrate Research2000, 329, 873.
Chen, X.; Zhang, W.; Wang, J.; Fang, J.; Wang, P. G.“Production of α-Galatosyl epitopes via combined use of two recombinant whole cells harboring UDP-galactose 4-epimerase and α-1,3-galactosyltransferase”. Biotechnology Progress2000, 16, 595.
Zhang, W.; Wang, P. G.“Ytterbium(III) trifluoromethanesulfonate catalyzed electrophilic aromatic substitution with glyoxalate and lipase-mediated product resolution: A convenient route to optically active aromatic α-hydroxy esters”. Journal of Organic Chemistry 2000,65, 4732.
Xian, M.; Wang, Q. M.; Chen, X.; Wang, K.; Wang, P. G.“S-nitrosothiols as novel, reversible inhibitors of human rhinovirus 3C protease”. Bioorganic and Medicinal Chemistry Letters2000, 10, 2097.
McGill, A.; Zhang, W.; Wittbrodt, J. M.; Wang, J.; Schlegel, H. B.; Wang, P. G.“Para-substituted N-nitroso-N-oxybenzenamine ammonium salts: a new class of redox-sensitive nitric oxide releasing compounds”. Bioorganic and Medicinal Chemistry 2000,8, 405.
Hou, Y.; Xie, W.; Janczuk, A. J.; Wang, P. G.“O-Alkylation of cupferron: Aiming at the design and synthesis of controlled nitric oxide releasing agents”. Journal of Organic Chemistry. 2000,65, 4333.
Hou, Y.; Xie, W.; Ramachandran, N.; Mutus, B.; Janczuk, A. J.; Wang, P. G.“O-Alkylation chemistry of neocupferron”. Tetrahedron Letters 2000,41, 451.
Wang, K.; Zhang, W.; Xian, M.; Hou, Y.; Chen, X.; Cheng, J.-P.; Wang, P. G.“New chemical and biological aspects of S-nitrosothiols”. Current Medicinal Chemistry 2000,7, 821.
Hou, Y.; Chen, Y.; Amro, N. A.; Wadu-Mesthrige, K.; Andreana, P.; Liu, G.-Y.; Wang, P. G.“Nanomolar scale nitric oxide generation from self-assembled monolayer modified gold electrodes”. Chemical Communications 2000, 19, 1831.
Chen, X.; Kowal, P.; Wang, P. G.“Large-scale enzymatic synthesis of oligosaccharides”. Current Opinion in Drug Discovery and Development2000, 3, 756.
Xian, M.; Wang, K.; Chen, X.; Hou, Y.; McGill, A.; Chen, X.; Zhou, B.; Zhang, Z.-Y.; Cheng, J.-P.; Wang, P. G.“Inhibition of protein tyrosine phosphatases by low-molecular-weight S-nitrosothiols and S-nitrosylated human serum albumin”. Biochemical and Biophysical Research Communications2000, 268, 310.
Xian, M.; Chen, X.; Liu, Z.; Wang, K.; Wang, P. G.“Inhibition of papain by S-nitrosothiols. Formation of mixed disulfides”. Journal of Biological Chemistry 2000,275, 20467.
Chen, X.; Liu, Z.; Wang, J.; Fang, J.; Fan, H.; Wang, P. G.“Changing the donor cofactor of bovine α-1,3-galactosyltransferase by fusion with UDP-galactose 4-epimerase. More efficient biocatalysis for synthesis of α-Gal epitopes”. Journal of Biological Chemistry 2000,275, 31594.
Cantuaria, G.; Magalhaes, A.; Angioli, R.; Mendez, L.; Mirhashemi, R.; Wang, J.; Wang, P. G.; Penalver, M.; Averette, H.; Braunschweiger, Pa. “Antitumor activity of a novel glyco-nitric oxide conjugate in human ovarian cancer”. Cancer2000, 88, 381.
Zhang, W.; Wang, J.; Li, J.; Yu, L.; Wang, P. G.“A Large-scale synthesis of an α-galactosyl trisaccharide epitope involved in the hyperacute rejection upon xenotransplantation”. Journal of Carbohydrate Chemistry1999, 18, 1009.
Chen, X.; Kowal, P.; Hamad, S.; Fan, H.; Wang, P. G.“Cloning, expression and characterization of a UDP-galactose 4-epimerase from Escherichia coli”. Biotechnology Letters 1999,21, 1131.
Chen, X.; Andreana, P.; Wang, P. G.“Carbohydrates in transplantation”. CurrentOpinion in Chemical Biology 1999, 3, 650.
Zhang, W.; Xie, W.; Fang, J.; Wang, P. G.“Ytterbium(III) trifluoromethanesulfonate catalyzed solid phase aza Diels-Alder reaction and subsequent facile adduct release”. Tetrahedron Letter 1999,40, 7929.
Xie, W.; Fang, J.; Li, J.; Wang, P. G.“Aziridine synthesis in protic media by using lanthanide triflates as catalysts”. Tetrahedron Letters 1999,55, 12929.
Wang, K.; Hou, Y.; Zhang, W.; Ksebati, M. B.; Xian, M.; Cheng, J.-P.; Wang, P. G.“15N NMR and electronic properties of S-nitrosothiols”. Bioorganic and Medicinal Chemistry Letter 1999,9, 2897.
Li, J.; Zacharek, S.; Chen, X.; Wang, J.; Zhang, W.; Janczuk, A.; Wang, P. G.“Bacteria targeted by human natural antibodies using α-gal conjugated receptor-specific glycopolymers”.Bioorganic and Medicinal Chemistry 1999, 7, 1549.
Wang, J.-Q.; Chen, X.; Zhang, W.; Zacharek, S.; Chen, Y.; Wang, P. G.“Enhanced inhibition of human anti-Gal antibody binding to mammalian cells by synthetic α-Gal epitope polymers”. Journal of American Chemical Society 1999,121, 8174.
Xie, W.; Chen, D.; Fan, X.; Li, J.; Wang, P. G.; Cheng, H. N.; Nickol, R. G. “Lithium chloride as catalyst for the ring-opening polymerization of lactide in the presence of hydroxyl-containing compounds”. Journal of Polymer Science, Part A: Polymer Chemistry1999,37, 3486.
Hou, Y.; Wang, J.; Andreana, P.; Cantauria, G.; Tarasia, S.; Sharp, L.; Braunschweiger, P. G.; Wang, P. G.“Targeting nitric oxide to cancer cells: Cytotoxicity studies of glyco-S-nitrosothiols”. Bioorganic and Medicinal Chemistry Letter 1999,9, 2255.
Li, J.; Cheng, H. N.; Nickol, R. G.; Wang, P. G.“Enzymatic modification of hydroxyethylcellulose by transgalactosylation with β-galactosidases”. Carbohydrate Research 1999,316, 133.
Chen, Y.; Heeg, M. J.; Braunschweiger, P. G.; Xie, W.; Wang, P. G.“A carbohydrate-linked cisplatin analogue having antitumor activity”. Angewandte Chemie International Edition1999, 38, 1768.
Wang, S.; Ramirez, J.; Chen, Y.; Wang, P. G.; Leblanc, R. M. “Surface chemistry, topography, and spectroscopy of a mixed monolayer of 10,12-pentacosadiynoic acid and its mannoside derivative at the air-water interface”. Langmuir 1999,15, 5623.
Li, J.; Ksebati, M. B.; Zhang, W.; Guo, Z.; Wang, J.; Yu, L.; Fang, J.; Wang, P. G.“Conformational analysis of an α-galactosyl trisaccharide epitope involved in hyperacute rejection upon xenotransplantation”. Carbohydrate Research 1999,315, 76.
Fang, J.; Chen, X.; Zhang, W.; Wang, J.; Andreana, P. R.; Wang, P. G.“A unique chemoenzymic synthesis of α-galactosyl epitope derivatives containing free amino groups: Efficient separation and further manipulation”.Journal of Organic Chemistry 1999, 64, 4089.
Xie, W.; Heeg, M. J.; Wang, P. G.“Formation and crystal structure of a polymeric La(H2salen) complex”. Inorganic Chemistry 1999,38, 2541.
Xie, W.; Bloomfield, K. M.; Jin, Y.; Dolney, N. Y.; Wang, P. G.“Lanthanide triflates catalyzed reactions of imines with indole in protic media”. Synlett 1999, 4, 498.
Li, J.; Xie, W.; Cheng, H. N.; Nickol, R. G.; Wang, P. G.“Polycaprolactone-modified hydroxyethyl cellulose films prepared by lipase-catalyzed ring-opening polymerization”. Macromolecules 1999,32, 2789.
Xie, W.; Jin, Y.; Wang, P. G.“Lanthanide triflates as unique Lewis acids”. Chemtech 1999,29, 23.
Li, J.; Robertson, D. E.; Short, J. M.; Wang, P. G.“Chemical and enzymic synthesis of glycoconjugates. 5. One-pot regioselective synthesis of bioactive galactobiosides using a CLONEZYME thermophilic glycosidase library”. Bioorganic and Medicinal Chemistry Letter 1999,9, 35.
Guo, Z.; Miranda, N.; Wang, P. G.“Protein S-nitrosating agents”. Methods in Enzymology1999, 301, 249.
Hou, Y.; Wang, J.-Q.; Ramirez, J.; Wang, P. G.“Glyco-S-nitrosothiols: sugar-SNAP, a new type of nitric oxide donor”. Methods in Enzymology 1999,301, 242.
McGill, A. D.; Yang, Y.; Wang, J.; Echegoyen, L.; Wang, P. G.“Redox-sensitive nitric oxide donors: nitric oxide generation through electrolysis”. Methods in Enzymology 1999,301, 235.
Hou, Y.; Wang, J.; Arias, F.; Echegoyen, L.; Wang, P. G.“Electrochemical studies of S-nitrosothiols”. Bioorganic and Medicinal Chemistry Letter 1998,8, 3065.
Li, J.; Robertson, D. E.; Short, J. M.; Wang, P. G.“Chemical and enzymic synthesis of glycoconjugates, 4. Control of regioselectivity in high yielding synthesis of (β-D-fucopyranosyl)-O-D-xylopyranosyl disaccharides using a CLONEZYME thermophilic glycosidase”. Tetrahedron Letters 1998,39, 8963.
Cheng, J.-P.; Xian, M.; Wang, K.; Zhu, X.; Yin, Z.; Wang, P. G.“Heterolytic and homolytic Y-NO bond energy scales of nitroso-containing compounds: Chemical origin of NO release and NO capture”. Journal of American Chemical Society 1998,120, 10266.
Martin, J.; Jaramillo G, L. M.; Wang, P. G.“Efficient synthesis of α-aldopyranosyl cyanides via radical cyanation reactions”. Tetrahedron Letters 1998,39, 5927.
Wang, J.-Q; Archer, C.; Li, J.; Bott, S. G.; Wang, P. G.“Thermophilic esterases/lipases as an effective tool for the resolution of nucleoside diastereoisomers: Convenient one-pot synthesis of α-L-taluronamide and β-D-alluronamide nucleosides”. Journal of Organic Chemistry 1998,63, 4850.
Fang, J.; Li, J.; Chen, X.; Zhang, Y.; Wang, J.; Guo, Z.; Zhang, W.; Yu, L.; Brew, K.; Wang, P. G.“Highly efficient chemoenzymic synthesis of α-galactosyl epitopes with a recombinant α-1,3-galactosyltransferase”. Journal of American Chemical Society 1998,120, 6635.
Guo, Z.; Ramirez, J.; Li, J.; Wang, P. G.“Peptidyl N-nitrosoanilines: A novel class of cysteine protease inactivators”. Journal of American Chemical Society 1998,120, 3726.
Fang, J.; Xie, W.; Li, J.; Wang, P. G.“Chemical and enzymic synthesis of glycoconjugates 3: synthesis of lactosamine by thermophilic galactosidase catalyzed galactosylation on a multigram scale”. Tetrahedron Letters 1998,39, 919.
Guo, Z.; Wang, P. G.“Utilization of glycosyltransferases to change oligosaccharide structures”. Applied Biochemistry and Biotechnology1997, 68, 1.
Streitwieser, A.; Wang, P. G.; Bors, D. A. “Equilibrium acidities of some sulfones and sulfoxides in tetrahydrofuran”. Tetrahedron Letters1997, 53, 10103-38.
Li, J.; Wang, P. G.“Chemical and enzymic synthesis of glycoconjugates 2. High yielding regioselective synthesis of N-acetyllactosamine by use of recombinant thermophilic glycosidases library”. Tetrahedron Letters 1997,38, 7967.
Xie, W.; Li, J.; Chen, D.; Wang, P. G.“Ring-opening polymerization of β-butyrolactone by thermophilic lipases”. Macromolecules 1997,30, 6997.
Yu, L.; Chen, D.; Li, J.; Wang, P. G.“Preparation, characterization, and synthetic uses of lanthanide(III) catalysts supported on ion exchange resins”. Journal of Organic Chemistry 1997,62, 3575.
Wang, S.; Li, Y.; Shao, L.; Ramirez, J.; Wang, P. G.; Leblanc, R. M. “Excess free energies of interaction between 10,12-pentacosadiynoic acid (PDA) and its mannoside derivative (MPDA). A mixed-monolayer study”. Langmuir 1997,13, 1677.
Yu, L.; Li, J.; Ramirez, J.; Chen, D.; Wang, P. G. “Synthesis of aza sugars via lanthanide-promoted aza diels-alder reactions in aqueous solution”. Journal of Organic Chemistry 1997,62, 903.
Yu, L.; Chen, D.; Li, J.; Ramirez, J.; Wang, P. G.; Bott, S. G. “Lanthanide-promoted reactions of aldehydes and amine hydrochlorides in aqueous solution. Synthesis of 2,3-dihydropyridinium and pyridinium derivatives”. Journal of Organic Chemistry 1997,62, 208.
Ramirez, J.; Yu, L.; Li, J.; Braunschweiger, P. G.; Wang, P. G.“Glyco-S-nitrosothiols, a novel class of NO donor compounds”. Bioorganic and Medicinal Chemistry Letter 1996,6, 2575.
Hou, Y.; Guo, Z.; Li, J.; Wang, P. G.“Seleno compounds and glutathione peroxidase catalyzed decomposition of S-nitrosothiols”. Biochemical and Biophysical Research Communications1996, 228, 88.
Chen, D.; Yu, L.; Wang, P. G.“Lewis acid-catalyzed reactions in protic media. Lanthanide-catalyzed reactions of indoles with aldehydes or ketones”. Tetrahedron Letters 1996,37, 4467.
Stratakis, M.; Wang, P. G.; Streitwieser, A. “Equilibrium ion pair acidities of polyhalogenated benzenes in THF. Extrapolation to benzene”. Journal of Organic Chemistry 1996,61, 3145.
Yu, L.; Chen, D.; Wang, P. G.“Aqueous aza Diels-Alder reactions catalyzed by lanthanide(III) trifluoromethanesulfonates”. Tetrahedron Letters 1996,37, 2169.
Guo, Z.; McGill, A.; Yu, L.; Li, J.; Ramirez, J.; Wang, P. G.“S-Nitrosation of proteins by N-methyl-N-nitrosoanilines”. Bioorganic and Medicinal Chemistry Letter 1996,6, 573.
Wartchow, C. A.; Wang, P. G.; Bednarski, M. D.; Callstrom, M. R. “Carbohydrate protease conjugates: Stabilized proteases for peptide synthesis”.Journal of Organic Chemistry 1995, 60, 2216.
Yu, L.; McGill, A.; Ramirez, J.; Wang, P. G.; Zhang, Z.-Y. “Synthesis and bioassay of a protein tyrosine phosphatase inhibitor, dephostatin”.Bioorganic and Medicinal Chemistry Letter 1995,5, 1003.
Yu, L.; Cabrera, R.; Ramirez, J.; Malinovskii, V. A.; Brew, K.; Wang, P. G.“Chemical and enzymic synthesis of glyconjugates. 1. Enzymic galactosylation of conduritol B”. Tetrahedron Letters 1995,36, 2897.
Sears, P. S.; Schuster, M.; Wang, P. G.; Wong, C.-H. “Engineering Subtilisin for Peptide Coupling”. Journal of American Chemical Society1994, 116, 6521.
Herrmann, G. F.; Wang, P. G.; Shen, G.-J.; Garcia-Junceda, E.; Khan, S. H.; Matta, K. L.; Wong, C.-H. “Large Scale Overexpression of Recombinant α-1,2-Mannosyltransferase in Escherichia Colifor the Study of Acceptor Specificity and Use of the Recombinant Whole Cells in Synthesis”. Journal of Organic Chemistry 1994, 5, 6356.
Schuster, M.; Wang, P. G.; Paulson, J. C.; Wong, C.-H. “Solid phase enzymatic synthesis of glycopeptides and oligosaccharides”. Journal of American Chemical Society1994, 116, 1135.
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Wong, C.-H.; Schuster, M.; Wang, P. G.; Sears, P. “Enzymatic synthesis of N- and O-linked glycopeptides”. Journal of American Chemical Society1993, 115, 5893.
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Wang, P. G.; Schuster, M.; Wang, Y. F.; Wong, C.-H. “Synthesis of phospholipid-inhibitor conjugates by enzymatic transphosphatidylation with phospholipase D”. Journal of American Chemical Society1993, 115, 10487.
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王鹏
讲席教授、博士生导师